Results 121 to 130 of about 9,868 (165)

Impaired MAPT/tau-secretory lysosomes are linked to cognitive vulnerability in Alzheimer patients. [PDF]

Autophagy
Sharma P, Pallavi A, Chatterjee A, Prasad VM, Gandasi NR, Saroja SR.   +5 more
europepmc   +1 more source

Plasma SNAP25 is increased in pre-clinical Alzheimer's disease and has prognostic value for cognitive decline and disease progression: a multi-cohort study

Das S, Trieu C, Belbin O, Goossens J, Braber Ad, Gonzalez A, Alcolea D, Boonkamp L, Houtkamp I, Bongers B, Veld Li‘, Barrett N, Fortea J, Lleo A, Flier Wvd, Harten Av, Vanmechelen E, Teunissen C, Verberk I.   +18 more
europepmc   +1 more source

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Altered levels of the synaptosomal associated protein SNAP-25 in schizophrenia

Biological Psychiatry, 1998
Identifying brain changes in schizophrenia has been a major research focus for many years. Although impressive gains have been made in neuroimaging and brain electrophysiology, molecular and cellular markers of schizophrenia have lagged. There are no consistent biochemical markers for schizophrenia pathophysiology and none that reflect treatment course.
P M, Thompson, A C, Sower, N I, Perrone-Bizzozero   +2 more
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Rat and gerbil pinealocytes contain the synaptosomal‐associated protein 25 (SNAP‐25)

Journal of Pineal Research, 1996
Abstract: It has recently been established that the neuroendocrine pinealocytes of mammals contain several synaptic membrane proteins that are involved in the regulation of vesicle trafficking in the nerve terminal. In the present study, we have conducted immunoblot and immunocytochemical analyses to demonstrate that another key component of the ...
P, Redecker, C, Weyer, D, Grube
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A review of the role of synaptosomal-associated protein 25 (SNAP-25) in neurological disorders

International Journal of Neuroscience, 2016
Synaptosomal-associated protein 25 kDa (SNAP-25) is one of the key proteins involved in the formation of neural soluble N-ethylmaleimide-sensitive factor attachment protein receptor complexes, which are responsible for the calcium-dependent exocytosis of neurotransmitters - a major step in neurotransmission and the key to normal functioning of brain ...
Aneeqa, Noor, Saadia, Zahid
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Differential Phosphorylation of Syntaxin and Synaptosome‐Associated Protein of 25 kDa (SNAP‐25) Isoforms

Journal of Neurochemistry, 1999
Abstract : The synaptic plasma membrane proteins syntaxin and synaptosome‐associated protein of 25 kDa (SNAP‐25) are central participants in synaptic vesicle trafficking and neurotransmitter release. Together with the synaptic vesicle protein synaptobrevin/vesicle‐associated membrane protein (VAMP), they serve as receptors for the general membrane ...
C, Risinger, M K, Bennett
openaire   +2 more sources

Decreased levels of synaptosomal associated protein 25 in the brain of patients with Down Syndrome and Alzheimer's disease

Electrophoresis, 1999
Synaptosomal associated protein 25 kDa (snap-25) is a widely distributed membrane-associated protein in the brain, mainly localized in nerve terminals. In nerve terminals, snap-25 participates in docking and/or fusion of synaptic vesicles with the plasmalemma, a process essential for synaptic vesicle exocytosis.
Nigel Cairns, M Fountoulakis
exaly   +3 more sources

Measuring synaptosomal associated protein-25 kDa in human cerebral spinal fluid

Journal of Psychiatric Research, 1998
Changes in the quantity and distribution of neuronal proteins have been reported in psychiatric and neurological illnesses. The majority of this work has been performed in post-mortem samples and the results are difficult to apply to clinical care. The objective of this study is to develop a methodology that can identify trace amounts of brain proteins
P M, Thompson, C, Rosenberger, S, Holt, N I, Perrone-Bizzozero   +3 more
openaire   +2 more sources

Cerebrospinal Fluid Synaptosomal-Associated Protein 25 Levels in Patients with Alzheimer’s Disease: A Meta-Analysis

Journal of Alzheimer’s Disease, 2022
Background: Several studies have shown increased levels of cerebrospinal fluid (CSF) synaptosomal-associated protein 25 (SNAP-25) in patients with Alzheimer’s disease (AD). However, results have been inconsistent thus far.
Qianqian, Liu, Hui, Liu, Sizhe, Zhang, Qijie, Yang, Lu, Shen, Bin, Jiao   +5 more
openaire   +2 more sources