Results 131 to 140 of about 9,868 (165)
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Neuropathology and Applied Neurobiology, 2007
Aims: This study quantified the density of the synaptic proteins synaptophysin and synaptosomal‐associated protein 25‐kDa (SNAP‐25) in brains from elderly Down's syndrome individuals. Methods: Six areas (frontal, occipital, parietal and temporal lobes, cerebellum and hippocampus) of post mortem brains from elderly Down's syndrome (DS) individuals ...
Downes EC +8 more
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Aims: This study quantified the density of the synaptic proteins synaptophysin and synaptosomal‐associated protein 25‐kDa (SNAP‐25) in brains from elderly Down's syndrome individuals. Methods: Six areas (frontal, occipital, parietal and temporal lobes, cerebellum and hippocampus) of post mortem brains from elderly Down's syndrome (DS) individuals ...
Downes EC +8 more
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Neuroscience, 1990
Synaptosomal-associated protein, 25 kD, (SNAP-25) is a novel protein containing a possible transition metal binding site and encoded by a neuronal-specific mRNA. We examined the distribution of SNAP-25 mRNA and protein in the hippocampal formation of the adult rat following kainic acid, colchicine, and entorhinal lesions.
J W, Geddes +5 more
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Synaptosomal-associated protein, 25 kD, (SNAP-25) is a novel protein containing a possible transition metal binding site and encoded by a neuronal-specific mRNA. We examined the distribution of SNAP-25 mRNA and protein in the hippocampal formation of the adult rat following kainic acid, colchicine, and entorhinal lesions.
J W, Geddes +5 more
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The identification of a novel synaptosomal-associated protein, SNAP-25, differentially expressed by neuronal subpopulations. [PDF]
Journal of Cell Biology, 1989 cDNA clones of a neuronal-specific mRNA encoding a novel 25-kD synaptosomal protein, SNAP-25, that is widely, but differentially expressed by diverse neuronal subpopulations of the mammalian nervous system have been isolated and characterized. The sequence of the SNAP-25 cDNA revealed a single open reading frame that encodes a primary translation ...
Gerry Higgins, Wilson M C, Higgins G A
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Neurochemical Research, 2012
Snap25 (synaptosomal-associated protein) is a 25 kDa protein, belonging to the SNARE-family (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) of proteins, essential for synaptic and secretory vesicle exocytosis. Snap25 has by immunohistochemistry been demonstrated in the rat pineal gland but the biological importance of this is ...
Karlsen, Anna S +4 more
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Snap25 (synaptosomal-associated protein) is a 25 kDa protein, belonging to the SNARE-family (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) of proteins, essential for synaptic and secretory vesicle exocytosis. Snap25 has by immunohistochemistry been demonstrated in the rat pineal gland but the biological importance of this is ...
Karlsen, Anna S +4 more
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Synaptosome-associated protein 25 (SNAP25) synthesis in terminal buttons of mouse motor neuron
Doklady Biochemistry and Biophysics, 2015Previously, we formulated the hypothesis of compartmentalized protein synthesis in axons of motor neurons. In the axon hillock, along the entire length of the axon and in its ending, specific proteins are locally synthesized, which ensure the function of each compartment.
Islamov R. +4 more
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Journal of Neurochemistry, 2007
AbstractMatrix metalloproteinases (MMPs) belong to a family of zinc dependent enzymes best studied for their role in cancer and inflammation. Though MMPs typically target extracellular proteins, here we show that MMP‐7, an MMP family member which lacks a C‐terminal hemopexin‐like domain, can cleave an intraneuronal protein that is critical to vesicular
Arek, Szklarczyk +4 more
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AbstractMatrix metalloproteinases (MMPs) belong to a family of zinc dependent enzymes best studied for their role in cancer and inflammation. Though MMPs typically target extracellular proteins, here we show that MMP‐7, an MMP family member which lacks a C‐terminal hemopexin‐like domain, can cleave an intraneuronal protein that is critical to vesicular
Arek, Szklarczyk +4 more
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Neuroscience, 2020
Neurotransmitter release is mediated by ceramide, which is generated by sphingomyelin hydrolysis. In the present study, we examined whether synaptosomal-associated protein 25 (SNAP-25) is involved in ceramide production and exocytosis. Neutral sphingomyelinase 2 (nSMase2) was partially purified from bovine brain and we found that SNAP-25 was enriched ...
Jong Hoon, Won +7 more
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Neurotransmitter release is mediated by ceramide, which is generated by sphingomyelin hydrolysis. In the present study, we examined whether synaptosomal-associated protein 25 (SNAP-25) is involved in ceramide production and exocytosis. Neutral sphingomyelinase 2 (nSMase2) was partially purified from bovine brain and we found that SNAP-25 was enriched ...
Jong Hoon, Won +7 more
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Annals of the Rheumatic Diseases, 2013
Background SNAP-25 protein is a protein contributory to plasma membrane and synaptic vesicle fusions which is a critical point in neurotransmission. SNAP-25 gene is associated with personality disorders, behavioral symptoms and psychological disorders that can develop later in life.
A. Balkarli +3 more
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Background SNAP-25 protein is a protein contributory to plasma membrane and synaptic vesicle fusions which is a critical point in neurotransmission. SNAP-25 gene is associated with personality disorders, behavioral symptoms and psychological disorders that can develop later in life.
A. Balkarli +3 more
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Neuroreport, 2001
SNAP-25 levels were measured in ventral hippocampus in subjects with unipolar depression (n = 12), bipolar disorder (n = 13), schizophrenia (n = 15) and controls (n = 15) using quantitative immunocytochemistry. SNAP-25 levels were reduced significantly in stratum oriens of bipolar patients compared with controls (p < 0.05); they were also reduced ...
S H, Fatemi +4 more
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SNAP-25 levels were measured in ventral hippocampus in subjects with unipolar depression (n = 12), bipolar disorder (n = 13), schizophrenia (n = 15) and controls (n = 15) using quantitative immunocytochemistry. SNAP-25 levels were reduced significantly in stratum oriens of bipolar patients compared with controls (p < 0.05); they were also reduced ...
S H, Fatemi +4 more
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Journal of Endocrinological Investigation, 2002
The aim of this study was to analyze the expression of SNAP-25 and syntaxin-1 in the adenohypophyses of hypothyroid rats. Rats were divided into: 1) controls; 2) thyroidectomized 40 days; and 3) thyroidectomized 40 days with replacement of T4 20 days after surgery.
J L, Quintanar, E, Salinas
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The aim of this study was to analyze the expression of SNAP-25 and syntaxin-1 in the adenohypophyses of hypothyroid rats. Rats were divided into: 1) controls; 2) thyroidectomized 40 days; and 3) thyroidectomized 40 days with replacement of T4 20 days after surgery.
J L, Quintanar, E, Salinas
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