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The synthesis of brain metabolic DNA (BMD) is modulated by learning and circadian oscillations and is not involved in cell division or DNA repair. Data from rats have highlighted its prevalent association with the mitochondrial fraction and its lack of identity with mtDNA.
Cefaliello, Carolina +3 more
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Journal of Neurochemistry, 1988
AbstractZinc uptake‘was studied in synaptosomes, isolated by the Ficoll flotation technique, using the radiotracer 65Zn. True uptake of zinc could be discriminated from binding to the outside of the synaptosomes by the absence of accumulation at 0°C and the dependency of the rate of uptake on the medium osmolarity.
Cornelis J A Van Den Hamer
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AbstractZinc uptake‘was studied in synaptosomes, isolated by the Ficoll flotation technique, using the radiotracer 65Zn. True uptake of zinc could be discriminated from binding to the outside of the synaptosomes by the absence of accumulation at 0°C and the dependency of the rate of uptake on the medium osmolarity.
Cornelis J A Van Den Hamer
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Experimental Neurology, 1969
Abstract The effects of neuraminidase and testicular hyaluronidase on the ultrastructure of synaptosomes, prepared from hippocampi of female Sprague-Dawley rats, were evaluated in sections of glutaraldehyde-fixed specimens by electron microscopy. Whereas incubation in testicular hyaluronidase (80 μl/ml) was without apparent effect, neuraminidase (100
W, Bondareff, J, Sjöstrand
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Abstract The effects of neuraminidase and testicular hyaluronidase on the ultrastructure of synaptosomes, prepared from hippocampi of female Sprague-Dawley rats, were evaluated in sections of glutaraldehyde-fixed specimens by electron microscopy. Whereas incubation in testicular hyaluronidase (80 μl/ml) was without apparent effect, neuraminidase (100
W, Bondareff, J, Sjöstrand
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A simple apparatus for studying the release of neurotransmitters from synaptosomes
European Journal of Pharmacology, 1974Maurizio Raiteri, Giulio Levi
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Nature, 1984
Investigations using synaptosomes, pinched-off nerve ending particles from brain, have greatly improved our knowledge of presynaptic function. However, these structures, like most nerve endings, are too small to be penetrated with microelectrodes.
J A, Umbach, C B, Gundersen, P F, Baker
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Investigations using synaptosomes, pinched-off nerve ending particles from brain, have greatly improved our knowledge of presynaptic function. However, these structures, like most nerve endings, are too small to be penetrated with microelectrodes.
J A, Umbach, C B, Gundersen, P F, Baker
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Preparation of chick brain synaptosomes and synaptosomal membranes
Biochimica et Biophysica Acta (BBA) - Biomembranes, 1976A method is described for the preparation of synaptosomes and synaptosomal membranes from chicken brain. Procedures for isolating rat synaptosomal membranes could not be used directly; several modifications of existing procedures are reported. Purity of the subcellular and subsynaptosomal fractions was monitored by electron microscopy and measurements ...
J A, Babitch +4 more
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Synaptosomes and Metamodulation of Receptors
2022Synaptosomes are re-sealed pinched off nerve terminals that maintain all the main structural and functional features of the original structures and that are appropriate to study presynaptic events. Because of the discovery of new structural and molecular events that dictate the efficiency of transmitter release and of its receptor-mediated control in ...
Anna, Pittaluga, Mario, Marchi
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Specific binding of crotoxin to brain synaptosomes and synaptosomal membranes
Toxicon, 1991Crotoxin, the presynaptic neurotoxin from Crotalus durissus terrificus, was iodinated and used to demonstrate high affinity, specific binding to guinea-pig (Cavia porcellus) brain synaptosomes and synaptosomal membrane fragments. 125I-crotoxin binding to the membrane fragments displays two binding plateaus, (Kd1 = 4 nM and Kd2 = 87 nM, Bmax1 = 2 and ...
L L, Degn, C S, Seebart, I I, Kaiser
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Synaptosome Antisera affect Permeability of Synaptosomal Membranes in vitro
Nature New Biology, 1972ANTISERA against specific regions of the brain can specifically influence the electrical activity of those regions1,2. It is possible that these immunological techniques may be used to determine the role of specific chemical components in brain function.
M, Raiteri, A, Bertollini, R, La Bella
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