A synthetic-lethality RNAi screen reveals an ERK-mTOR co-targeting pro-apoptotic switch in PIK3CA+ oral cancers. [PDF]
, 2016 mTOR inhibition has emerged as a promising strategy for head and neck squamous cell carcinomas (HNSCC) treatment. However, most targeted therapies ultimately develop resistance due to the activation of adaptive survival signaling mechanisms limiting the ...
Amornphimoltham, Panomwat +10 more
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Synergistic Activity of Fosfomycin, Ciprofloxacin, and Gentamicin Against Escherichia coli and Pseudomonas aeruginosa Biofilms [PDF]
, 2019 Gram-negative (GN) rods cause about 10% periprosthetic joint infection (PJI) and represent an increasing challenge due to emergence of antimicrobial resistance.
Di Luca, Mariagrazia +4 more
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, 2014 Citation: 'synergism' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.S06229 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
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Combined immunosuppressive therapy with low dose FK506 and antimetabolites in rat allogeneic heart transplantation [PDF]
, 1994 Following rat heterotopic heart allotransplantation, low to lethal doses of the antimetabolites mizoribine (MIZ), RS-61443 (RS), and AZA were given alone or in combination with subtherapeutic doses of FK506 (0.04 mg/kg/day) for 14 days after ...
Fujisaki, S +6 more
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Ocean warming-acidification synergism undermines dissolved organic matter assembly. [PDF]
, 2015 Understanding the influence of synergisms on natural processes is a critical step toward determining the full-extent of anthropogenic stressors. As carbon emissions continue unabated, two major stressors--warming and acidification--threaten marine ...
Anaya, Jesse M +4 more
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Computational analyses of synergism in small molecular network motifs. [PDF]
PLoS Computational Biology, 2014 Cellular functions and responses to stimuli are controlled by complex regulatory networks that comprise a large diversity of molecular components and their interactions.
Yili Zhang +3 more
doaj +1 more source
Toll-like receptor 4 mediates synergism between alcohol and HCV in hepatic oncogenesis involving stem cell marker Nanog [PDF]
, 2009 Alcohol synergistically enhances the progression of liver disease and the risk for liver cancer caused by hepatitis C virus (HCV). However, the molecular mechanism of this synergy remains unclear.
Asahina, Kinji +13 more
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Propolis: anti-Staphylococcus aureus activity and synergism with antimicrobial drugs
Memorias do Instituto Oswaldo Cruz, 2005 Propolis is a natural resinous substance collected by bees from tree exudates and secretions. Its antimicrobial activity has been investigated and inhibitory action on Staphylococcus aureus growth was evaluated.
Ary Fernandes Júnior +5 more
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Novel insights into the synergistic interaction of Bortezomib and TRAIL: tBid provides the link [PDF]
, 2011 The proteasome inhibitor Bortezomib has been identified as a potent enhancer of TRAIL-induced apoptosis in several human cancers. However, the identification of the underlying molecular mechanisms of this synergistic cell death induction has been ongoing
Fulda, Simone
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Lead optimisation of dehydroemetine for repositioned use in malaria [PDF]
, 2020 Drug repositioning offers an effective alternative to de novo drug design to tackle the urgent need for novel anti-malarial treatments. The anti-amoebic compound, emetine dihydrochloride, has been identified as a potent in-vitro inhibitor of the multi ...
Abubaker, M +8 more
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