Results 31 to 40 of about 158,281 (297)

Fundamental Concepts in the Assessment of Interaction of Biological Response Modifiers with other Agents

Canadian Journal of Infectious Diseases, 1992
The universal response surface approach (URSA) was developed to assess the nature and intensity of drug interactions, ie, synergism. antagonism and additivity.
William R Greco, Wlodzimierz E Dembinski
doaj   +1 more source

Autoimmune conditions and comorbid depression in pregnancy: examining the risk of preterm birth and preeclampsia. [PDF]

, 2017
ObjectiveThe objective of this study was to determine whether prenatal depression interacts with autoimmune conditions to further increase the risk of preterm birth or preeclampsia.Study designOur sample included 3034 pregnant women with rheumatoid ...
Bandoli, G, Chambers, CD
core   +1 more source

Top coal caving mining technique in thick coal seam beneath the earth dam

International Journal of Mining Science and Technology, 2017
It is important to study the mining technology under structures for raising the coal resources recovery ratio. Based on the geological and mining conditions, the top coal caving harmonic mining technique in thick coal seam beneath the earth dam was put ...
Wenbing Guo, Yi Tan, Erhu Bai
doaj   +1 more source

Effect of Sequential Inoculation of Tetragenococcus halophilus and Wickerhamomyces anomalus on the Flavour Formation of Early-Stage Moromi Fermented at a Lower Temperature

Foods, 2023
Microbial inoculation in moromi fermentation has a great influence on the physicochemical and flavour properties of soy sauces. This work investigated the effect of inoculating Tetragenococcus halophilus and Wickerhamomyces anomalus on the flavour ...
Xinzhi Li, Xinyu Xu, Changzheng Wu, Xing Tong, Shiyi Ou   +4 more
doaj   +1 more source

Toward a thermodynamic framework for identifying and quantifying chemical synergism in heterogeneous systems

Chemical Engineering Journal Advances
Chemical synergism is widely invoked to explain performance enhancement in heterogeneous catalytic and multiphase engineering systems, yet the term is frequently used without rigorous physicochemical criteria, leading to confusion between genuine ...
Natalia Bolocan, Igor Povar
doaj   +1 more source

PARP1 expression drives the synergistic antitumor activity of trabectedin and PARP1 inhibitors in sarcoma preclinical models

Molecular Cancer, 2017
Background Enhancing the antitumor activity of the DNA-damaging drugs is an attractive strategy to improve current treatment options. Trabectedin is an isoquinoline alkylating agent with a peculiar mechanism of action.
Ymera Pignochino, Federica Capozzi, Lorenzo D’Ambrosio, Carmine Dell’Aglio, Marco Basiricò, Marta Canta, Annalisa Lorenzato, Francesca Vignolo Lutati, Sandra Aliberti, Erica Palesandro, Paola Boccone, Danilo Galizia, Sara Miano, Giulia Chiabotto, Lucia Napione, Loretta Gammaitoni, Dario Sangiolo, Maria Serena Benassi, Barbara Pasini, Giovanna Chiorino, Massimo Aglietta, Giovanni Grignani   +21 more
doaj   +1 more source

Cytotoxic Marine Alkaloid 3,10-Dibromofascaplysin Induces Apoptosis and Synergizes with Cytarabine Resulting in Leukemia Cell Death

Marine Drugs, 2021
Myeloid leukemia is a hematologic neoplasia characterized by a clonal proliferation of hematopoietic stem cell progenitors. Patient prognosis varies depending on the subtype of leukemia as well as eligibility for intensive treatment regimens and ...
Pavel Spirin, Elena Shyrokova, Timofey Lebedev, Elmira Vagapova, Polina Smirnova, Alexey Kantemirov, Sergey A. Dyshlovoy, Gunhild von Amsberg, Maxim Zhidkov, Vladimir Prassolov   +9 more
doaj   +1 more source

Midazolam inhibits hippocampal long-term potentiation and learning through dual central and peripheral benzodiazepine receptor activation and neurosteroidogenesis [PDF]

, 2010
Benzodiazepines (BDZs) enhance GABA(A) receptor inhibition by direct actions on central BDZ receptors (CBRs). Although some BDZs also bind mitochondrial receptors [translocator protein (18 kDa) (TSPO)] and promote the synthesis of GABA-enhancing ...
Izumi, Yukitoshi, O\u27Dell, Kazuko A, Tokuda, Kazuhiro, Zorumski, Charles F   +3 more
core   +2 more sources

Silver Nanoparticles Enhance Antimicrobial Efficacy of Antibiotics and Restore That Efficacy against the Melioidosis Pathogen

Antibiotics, 2021
Melioidosis is an infectious disease caused by Gram-negative bacillus bacteria Burkholderia pseudomallei. Due to the emerging resistance of B. pseudomallei to antibiotics including ceftazidime (CAZ), the development of novel antibiotics and alternative ...
Sathit Malawong, Saengrawee Thammawithan, Pawinee Sirithongsuk, Sakda Daduang, Sompong Klaynongsruang, Pamela T. Wong, Rina Patramanon   +6 more
doaj   +1 more source

Fos co-operation with PTEN loss elicits keratoacanthoma not carcinoma due to p53/p21^WAF-induced differentiation triggered by GSK3b inactivation and reduced AKT activity [PDF]

, 2008
To investigate gene synergism in multistage skin carcinogenesis, the RU486-inducible cre/lox system was employed to ablate PTEN function [K14.cre/D5PTENflx] in mouse epidermis expressing activated v-fos [HK1.fos].
Alexander, C.L., Chan, W-C., Greenhalgh, D.A., Quinn, J., Wu, H., Yao, D.   +5 more
core   +1 more source