Results 151 to 160 of about 660,576 (241)

Genomic Diversity of the Endangered Guinan Toad‐Headed Lizard and Its Conservation Implications

Integrative Zoology, EarlyView.
We produced HiFi long reads and assembled a high‐quality genome for the Guinan toad‐headed lizard—Phrynocephalus guinanensis—and present a comprehensive conservation genomics assessment. Our findings clearly show population structure, a reduced genetic diversity pattern, and a strong bottleneck in demographic history, reaffirming the endangered status ...
Ying Chen, Song Tan, Yiru Wang, Xia Qiu, Da Kang, Weizhao Yang   +5 more
wiley   +1 more source

Role of a Synonymous Mutation at Codon 178 in P1 That Attenuates Potato Virus Y-Induced Tobacco Vein Necrosis and Its Application for Expressing Human Interferon. [PDF]

Mol Plant Pathol
Liu DG, Wang YY, Zhu Q, Huang XW, Yan XY, Jia MA, Guo YS, Cao LG, Jiang J, Li XD, Zhang XL, Tian YP.   +11 more
europepmc   +1 more source

Evolutionary Mechanisms of Coagulation Factors in Cetaceans During Aquatic Adaptation

Integrative Zoology, EarlyView.
Compared with Bos taurus, T. truncatus showed shorter prothrombin time and thrombin time but prolonged activated partial thromboplastin time, indicating pathway‐specific remodeling of coagulation. Evolutionary analyses identified 18 positively selected genes and accelerated F11 evolution, while functional assays revealed increased coagulation factor ...
Wenjun Lv, Wanfei Deng, Fei Deng, Shixia Xu, Wenhua Ren   +4 more
wiley   +1 more source

Overexpression of Rtl1 via synonymous mutation silencing miRNA target site drives skeletal muscle hypertrophy and inflammation in mice. [PDF]

BMC Biol
Song X, Niu L, Fan X, Xu X, Zhao Z, Zhang Z, Tong Y, Huang H, Zhu Z, Cheng H, Xie S, Xu X.   +11 more
europepmc   +1 more source

The combination of bevacizumab/Avastin and erlotinib/Tarceva is relevant for the treatment of metastatic renal cell carcinoma: the role of a synonymous mutation of the EGFR receptor. [PDF]

Theranostics, 2020
Grépin R, Guyot M, Dumond A, Durivault J, Ambrosetti D, Roussel JF, Dupré F, Quintens H, Pagès G.   +8 more
europepmc   +1 more source

A Spotlight on Yolk‐sac Tumors: Molecular Pathology, Current Diagnostics, and Novel Therapeutics

Andrology, EarlyView.
ABSTRACT Background Yolk‐sac tumors are an aggressive subtype of testicular cancer that significantly contribute to disease progression and therapy resistance, especially in adults. While testicular cancer generally has high cure rates with cisplatin‐based treatment, adult yolk‐sac tumors often appear as components of mixed tumors with poor response to
Evangelos Prokakis, Lisa Schneider, Felix Bremmer, Daniel Nettersheim   +3 more
wiley   +1 more source

DRP-PSM: Multi-Level Feature Integration Reveals Hierarchical Contributions to Pathogenic Synonymous Mutation Prediction. [PDF]

ACS Omega
Cai J, Jin F, Cheng N, Xia J, Ye C.
europepmc   +1 more source

Dystrophia Smolandiensis is characterized by a novel NQO1 variant and a distinct phenotype from COL17A1‐associated epithelial recurrent erosion dystrophy

Acta Ophthalmologica, EarlyView.
Abstract Purpose To determine the molecular cause of the two epithelial recurrent erosion dystrophies, Dystrophia Smolandiensis and Dystrophia Helsinglandica, and to identify phenotypic differences between the two conditions. Methods DNA samples and clinical data from structured interview records were obtained from the Swedish families in which ...
Karl De Geer, Kristina Lagerstedt‐Robinson, Daniel Nilsson, Cilla Söderhäll, Björn Hammar, Erik Björck   +5 more
wiley   +1 more source

Clinical periodontal diagnosis

Periodontology 2000, EarlyView., 2023
Abstract Periodontal diseases include pathological conditions elicited by the presence of bacterial biofilms leading to a host response. In the diagnostic process, clinical signs such as bleeding on probing, development of periodontal pockets and gingival recessions, furcation involvement and presence of radiographic bone loss should be assessed prior ...
Giovanni E. Salvi, Andrea Roccuzzo, Jean‐Claude Imber, Alexandra Stähli, Björn Klinge, Niklaus P. Lang   +5 more
wiley   +1 more source

A cancer-associated TP53 synonymous mutation induces synthesis of the p53 isoform p53/47. [PDF]

Br J Cancer
Sajwan R, Wang L, Casar-Borota O, Karakostis K, Chen S, Fahraeus R, Gu X, Vadivel Gnanasundram S.   +7 more
europepmc   +1 more source