Results 161 to 170 of about 660,576 (241)

PTEN homozygous deletion is a negative prognostic factor in tumor treating fields‐treated glioblastoma, IDH wildtype patients

Brain Pathology, EarlyView.
In a molecularly confirmed cohort of 64 newly diagnosed, TTFields‐treated glioblastomas, IDH‐wildtype, homozygous PTEN deletion was associated with markedly shorter overall survival (368 vs. 603 days) and remained an independent adverse prognostic factor.
Jakob Nückles, Claudius Jelgersma, Christin Siewert, Brendan Osberg, Simone Schmid, Arend Koch, Eilís Perez, Daniel Teichmann, Martin Misch, Anna‐Gila Karbe, Susanne Ukrow, Patrick N. Harter, Ruth M. Stassart, Peter Vajkoczy, Julia Onken, David Capper   +15 more
wiley   +1 more source

The potential for biased signalling in the P2Y receptor family of GPCRs

British Journal of Pharmacology, EarlyView.
The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk, Simon Pitchford, Graham Ladds   +2 more
wiley   +1 more source

A U508C synonymous mutation in the SARS-CoV-2 deletion hotspot reduces deletion frequency and accelerates viral clearance. [PDF]

mBio
Miyazaki K, Doi A, Tomita Y, Kamitani W, Matsuyama S.   +4 more
europepmc   +1 more source

The non-synonymous mutation in bovine SPP1 gene influences carcass weight. [PDF]

Heliyon, 2019
Matsumoto H, Kohara R, Sugi M, Usui A, Oyama K, Mannen H, Sasazaki S.   +6 more
europepmc   +1 more source

Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges

British Journal of Pharmacology, EarlyView.
This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu, Kaibin Dai, Zhensheng Lin, Mingfang Ye, Minfeng Chen, Xiaobo Li, Dongmei Zhang   +6 more
wiley   +1 more source

Machine Learning‐Derived Immune Gene Signature Predicts Prognosis and Therapeutic Vulnerabilities in Multiple Myeloma

Cancer Science, EarlyView.
An immune‐related 12‐gene signature developed through integrative machine learning stratified overall survival across multiple myeloma cohorts and remained independently associated with outcome. Single‐cell, somatic mutation, and transcriptome‐based drug‐response analyses further linked the signature to multicellular bone marrow context, distinct ...
Kai Wang, Chenfei Zhao, Jingru Shi, Shiwei Liu, Yi Chen, Jujuan Wang, Zhengxu Sun, Sanmei Wang, Lei Fan, Jin Fan, Xiaoyan Qu   +10 more
wiley   +1 more source

Transcriptomic and metabolomic profiles reveal the functions of IGF-1 c.258 A > G synonymous mutation in milk fat content. [PDF]

J Adv Res
Fang J, Zheng S, Zhang X, Chen X, Li Y, Zhang L, Xiao X, Cheng Y, Xu Y, Hao L.   +9 more
europepmc   +1 more source

Advances in Spatial Heterogeneity and Cellular Localization Specificity of Intratumoral Bacteria

Cancer Science, EarlyView.
Spatial localization of intratumoral bacteria governs their functional roles in tumor progression, metastasis, and treatment responses, with guiding significance for clinical management, as reviewed across three spatial paradigms. ABSTRACT Bacteria in tumors are increasingly recognized to be a part of the tumor microenvironment and their biological ...
Minlan Ren, Jing Jia, Tingting Li, Yiwei Li, Nanxiang Shen, Yun Shi, Zhe Wang, Hao Fan, Guangli Sun, Guanying Xiong, Gang Li, Rui Peng   +11 more
wiley   +1 more source

CHOROIDEREMIA ASSOCIATED WITH A NOVEL SYNONYMOUS MUTATION IN GENE ENCODING REP-1. [PDF]

Retin Cases Brief Rep, 2018
Sengillo JD, Lee W, Bakhoum MF, Cho GY, Chiang JP, Tsang SH.   +5 more
europepmc   +1 more source

Assessment of MRD and Longitudinal Monitoring of Post‐Surgery Biliary Tract Cancer With a Customized ctDNA Panel

Cancer Science, EarlyView.
A customized panel was established for BTC MRD detection. Preoperative ctDNA detection was associated with pathological stage and poorer RFS and OS. Longitudinal monitoring detected ctDNA before radiological recurrence in 72.7% of patients, with a median lead time of 77 days, supporting ctDNA as a complementary prognostic biomarker with CA19‐9 ...
Yoshihito Shinohara, Toru Nakamura, Yasutoshi Kimura, Takeshi Murakami, Shigeyuki Kojima, Toshikazu Yamaguchi, Kanako C. Hatanaka, Ryo Okazaki, Yosuke Kitayama, Keita Fukuda, Fabio Pittella‐Silva, Yusuke Nakamura, Satoshi Hirano, Siew‐Kee Low   +13 more
wiley   +1 more source