Results 181 to 190 of about 660,576 (241)

Blocking protein quality control degradation leads to structural stabilization of DHFR indel variants

The FEBS Journal, EarlyView.
Blocking protein quality control degradation by deleting the E3 ligases Ubr1 or San1 stabilizes many DHFR insertion and deletion variants that are otherwise partially unfolded. These hypomorphic variants regain folding at lower temperatures or upon methotrexate binding, revealing that PQC degradation can remove proteins that are still functionally ...
Sven Larsen‐Ledet, Caroline H. Suhr, Sarah Gersing, Celeste M. Hackney, Amelie Stein, Kaare Teilum, Rasmus Hartmann‐Petersen   +6 more
wiley   +1 more source

Convergent mutations underpin the repeated evolution of brown plumage in seabirds

Ibis, EarlyView.
Recent genetic data have provided crucial insights into the evolution of animal colour phenotypes, with the melanocortin‐1 receptor (MC1R) frequently implicated in dramatic colour shifts. However, the extent to which similar phenotypes are underpinned by convergent mutations at this locus remains unclear.
Shanshan Shen, Graham A. McCulloch, Tania M. King, Nicolas J. Rawlence, Martyn Kennedy, Jonathan M. Waters   +5 more
wiley   +1 more source

Word Associations in a Minoritised Language: The Case of Cymraeg (Welsh)

International Journal of Applied Linguistics, EarlyView.
ABSTRACT As with many research strands in linguistics, word association (WA) literature is dominated by English language data. This paper (i) explores the extent to which methodologies developed to date are applicable to other languages—specifically, Welsh (Cymraeg)—and (ii) investigates what WA analysis can reveal about lexical organisation and ...
Tess Fitzpatrick, Steve Morris, Theodore Mills   +2 more
wiley   +1 more source

Myelodysplasia‐Related Gene Mutation Burden Is Associated With Complete Remission After Induction Therapy in Acute Myeloid Leukemia, Not Otherwise Specified: Reclassification According to the Updated Classifications

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Introduction Updated classifications incorporating myelodysplasia‐related (MR) gene mutations reclassify many cases previously diagnosed as acute myeloid leukemia, not otherwise specified (AML, NOS). We evaluated the clinical significance of MR gene mutation burden, defined by mutation number and variant allele frequency (VAF), in AML, NOS ...
Taegeun Lee, Daehyun Chu, Miyoung Kim, Young‐Uk Cho, Sang‐Hyun Hwang, Je‐Hwan Lee, Yunsuk Choi, Eun‐Ji Choi, Ho Joon Im, Hyery Kim, Seongsoo Jang   +10 more
wiley   +1 more source

Climate‐driven niche filtering limits post‐dispersal establishment and genomic introgression in a riverine shrub

Journal of Integrative Plant Biology, EarlyView.
Integrated biogeographic analysis and macroecological insights reveal that habitat differences drive genetic differentiation Debregeasia orientalis C. J. Chen, a dominant riparian shrub distributed across multiple biodiversity hotspots, and different lineages vary greatly in adaptability to future climate.
Zeng‐Yuan Wu, Mark A. Chapman, Richard I. Milne, Jie Liu, Ya‐Huang Luo, Peng‐Zhen Fan, Guang‐Fu Zhu, Jason T. Weir, Richard T. Corlett, Xiao‐Gang Fu, Toby P. N. Tsang, Marc W. Cadotte, De‐Zhu Li   +12 more
wiley   +1 more source

RING E3 ligase SNIPER8 functions redundantly with three close homologs to regulate the turnover of transcriptional co‐repressor TPR1

Journal of Integrative Plant Biology, EarlyView.
The Arabidopsis E3 ligase SNIPER8 negatively regulates immunity by promoting ubiquitination and proteasomal degradation of the transcriptional corepressor TOPLESS‐RELATED1, limiting excessive immune responses, maintaining immune homeostasis, and balancing defense activation and normal plant growth.
Xueru Liu, Paul Kapos, Zhongshou Wu, Yujun Peng, Meixuezi Tong, Asana Khajavi, Yan Huang, Yuelin Zhang, Xin Li   +8 more
wiley   +1 more source

Natural variation in the GNH1 promoter enhances plant height and grain yield in rice

Journal of Integrative Plant Biology, EarlyView.
Natural variation in the GRAIN NUMBER AND PLANT HEIGHT 1 (GNH1) promoter alleviates repression by the C2H2‐type transcription factor ZFP36, upregulating GNH1 expression and promoting auxin accumulation, thereby increasing rice plant height and grain yield. This elite allele serves as a valuable genetic resource for molecular breeding of high‐yield rice.
Hongwei Xing, Huan Wang, Sheng Wu, Yuanjie Li, Kun Zhang, Chuanqing Sun, Hongying Sun   +6 more
wiley   +1 more source

The Keystone‐Pathogen Hypothesis Updated: The Role of Porphyromonas gingivalis in Periodontitis

Journal of Periodontal Research, EarlyView.
Porphyromonas gingivalis orchestrates a coordinated manipulation of immune and inflammatory responses in periodontal tissues which leads to the generation of a dysbiotic, subgingival biofilm community, and progression of periodontitis. The type 9 secretion system, lipid A modification, and the formation of outer membrane vesicles are important ...
Mike A. Curtis, James A. Garnett, Richard P. Darveau   +2 more
wiley   +1 more source

Genetic, phenotypic, and ecological differentiation indicate a new cryptic and threatened species in the orchid genus Epidendrum from Alcatrazes Island, southeastern Brazil

Journal of Systematics and Evolution, EarlyView.
Epidendrum insularis occurs on the remote Alcatrazes Island in the southeastern Brazilian coast. The description of this new cryptic species was only possible by the joint use of molecular markers, reproductive experiments, flower morphometry, functional traits, and community analysis.
Beatriz L. Arida, Giovana N. Trotta, Beatriz C. De Marco, Iris D. P. Ribeiro, Raphael da Silva, Thales M. de Lima, Welington L. Sachetti Junior, Vitor de A. Kamimura, Gabriel P. Sabino, Bárbara S. S. Leal, Lívia Garcia, Edlley M. Pessoa, Fabio Pinheiro   +12 more
wiley   +1 more source

Rapid Translation of the Early Coding Region Promotes Premature Transcription Termination, Reducing Protein Expression in Escherichia coli

Molecular Microbiology, EarlyView.
A run of consecutive fast‐translated codons (right) within the first 30 codons of lacZ (top) causes loss of the downstream transcript at positions coinciding with previously mapped intragenic Rho‐dependent termination sites (middle), and a corresponding loss of β‐galactosidase activity (bottom).
Steen Pedersen, Alberte Honoré Jepsen, Bertil Gummesson, Namiko Mitarai, Kim Sneppen, Sine Lo Svenningsen   +5 more
wiley   +1 more source