Results 101 to 110 of about 1,278,587 (252)

Deep molecular profiling of synovial biopsies in the STRAP trial identifies signatures predictive of treatment response to biologic therapies in rheumatoid arthritis

Nature Communications
Approximately 40% of patients with rheumatoid arthritis do not respond to individual biologic therapies, while biomarkers predictive of treatment response are lacking.
Myles J. Lewis, C. Çubuk, Anna E. A. Surace, E. Sciacca, Rachel Lau, K. Goldmann, G. Giorli, L. Fossati-Jimack, A. Nerviani, F. Rivellese, C. Pitzalis, Louise Warren, E. Jaworska, M. Bombardieri, F. Humby, A. Pratt, Andrew Filer, N. Gendi, A. Cauli, Ernest Choy, Iain B. McInnes, P. Durez, Christopher J. Edwards, Maya H. Buch, E. Gremese, Peter C. Taylor, N. Ng, J. D. Cañete, Sabrina Raizada, Neil D. Mckay, Deepak Jadon, P. Sainaghi, R. Stratton, M. Ehrenstein, P. Ho, Joaquim Pereira, B. Dasgupta, Claire Gorman, A. Zayat, A. R. Machado, A. Cuervo, A. Mahto, C. Rawlings, C. Mosanya, Christopher D. Buckley, C. Holroyd, Deborah Maskall, F. Carlucci, Georgina Thorburn, G. Tan, G. Lliso-Ribera, H. Rizvi, Joanna Peel, J. E. Fonseca, J. Isaacs, J. Ramírez, L. M. de Bellefon, Mary Githinji, M. Congia, N. Millar, N. Purkayastha, R. Seth, R. Celis, Rebecca Hands-Greenwood, R. Landewé, S. Perniola, S. Alivernini, S. Marcia, S. Marini, Stephen Kelly, V. Romão, James Galloway, H. Chinoy, D. M. van der Heijde, P. Sasieni, A. Barton   +75 more
semanticscholar   +1 more source

Severe neck stiffness in a 20‐year‐old gelding with cytological findings suggestive of cervical vertebral neoplasm

Equine Veterinary Education, EarlyView.
Summary A 20‐year‐old warmblood gelding was referred for the evaluation of severe cervical stiffness and pain. Radiographic examination revealed marked arthropathy of the C3–C4 articular processes, with severe remodelling and narrowing of the C3–C4 intervertebral space.
F. Bonaspetti, E. Porzio, M. Sforna, A. Mascioni, F. Beccati   +4 more
wiley   +1 more source

Arthroscopic synovial biopsy in definitive diagnosis of joint diseases: An evaluation of efficacy and precision

International Journal of Applied and Basic Medical Research, 2012
Context: Arthritis is an important cause of morbidity, presenting as monoarticular or polyarticular lesion. Arthroscopic synovial aspiration and biopsy can help in arriving specific etiological diagnosis.
Onis Singhal, V. Kaur, S. Kalhan, M. Singhal, Anshu Gupta, Y. Machave   +5 more
semanticscholar   +1 more source

Genetic Susceptibility to Periodontitis

Journal of Periodontal Research, EarlyView.
Aim: The aim of this narrative review was to identify genes carrying risk alleles associated with an increased risk of periodontitis and to place them in a biological context. Methods: The literature was reviewed based on predefined criteria. Results: The identified genes largely fall into functions linking immune response with tissue repair. The genes
Gesa M. Richter, Arne S. Schaefer
wiley   +1 more source

Intraosseous synovial sarcoma of the distal ulna: a case report and review of the literature

BMC Cancer, 2019
Background Synovial sarcoma is a relatively rare type of soft tissue sarcoma. The commonly observed symptom is a deep-seated palpable mass accompanied by pain or tenderness. Thus, it is considered a soft tissue sarcoma and rarely occurs primarily in bone.
Taketsugu Fujibuchi, Joji Miyawaki, Teruki Kidani, Hiroshi Imai, Hiroshi Kiyomatsu, Riko Kitazawa, Hiromasa Miura   +6 more
doaj   +1 more source

Harnessing the Therapeutic Potential of Cell Secretomes and Extracellular Vesicles for Craniofacial Regenerative Applications

Journal of Periodontal Research, EarlyView.
The scoping review summarizes the current preclinical and clinical evidence for the use of “cell‐free” therapies in craniofacial (periodontal, bone and soft‐tissue) regeneration. It also aims to highlight key challenges and strategies towards the clinical translation of these therapies.
Siddharth Shanbhag, Magdalena Mayol, Danijel Domic, Madhusudhan Reddy Bobbili, Johannes Grillari, Mariano Sanz, Reinhard Gruber   +6 more
wiley   +1 more source

Autoimmunity and Periodontitis

Journal of Periodontal Research, EarlyView.
In a microbe‐driven inflammatory environment, peptidyl‐arginine deiminase (PAD) enzymes from neutrophils and Porphyromonas gingivalis citrullinate both microbial and self‐antigens. B cell presentation of citrullinated or self‐mimicking epitopes activates T cells that assist B cells in antibody isotype switching, affinity maturation, epitope spreading ...
Massimo Costalonga, Vivek Thumbigere‐Math, Mark C. Herzberg   +2 more
wiley   +1 more source

Biopsy-Driven Synovial Pathophenotyping in RA: A New Approach to Personalized Treatment

The diagnosis and treatment of rheumatoid arthritis (RA) have been constantly evolving for decades, pointing towards early diagnostic and therapeutic interventions. Synovial biopsy has emerged as a pivotal tool in precision medicine, transitioning from a
Riccardo Terenzi, Sheyda Ketabchi, Mariangela Manfredi, Alessandro Mannoni, Cassar\ue0, Emanuele Antonio Maria, Francesca Li Gobbi, Maria Infantino, Infantino, Maria, Edda Russo, Mannoni, Alessandro, Terenzi, Riccardo, Benucci, Maurizio, Ketabchi, Sheyda, Emanuele Antonio Maria Cassarà, Maurizio Benucci, Li Gobbi, Francesca, Russo, Edda, Manfredi, Mariangela   +17 more
core   +1 more source

Periodontal Medicine Rewired: Mechanisms Linking Periodontitis to Systemic Diseases

Journal of Periodontal Research, EarlyView.
This review reorganizes decades of research in periodontal medicine into a multi‐dimensional framework, illustrating how periodontitis influences systemic health through at least seven interconnected mechanisms. ABSTRACT Periodontitis is now recognized not merely as a localized oral condition but as a systemic disease linked to over 70 communicable and
Mario Romandini, George Hajishengallis, Mike Curtis, Giacomo Baima   +3 more
wiley   +1 more source

Punch Biopsy of Synovial Membrane [PDF]

Annals of the Rheumatic Diseases, 1951
H F, POLLEY, W H, BICKEL
openaire   +4 more sources