Results 141 to 150 of about 1,278,587 (252)

Recalibrating the apoptotic threshold: Ubiquitin‐regulated ER stress signalling in colorectal cancer

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
Ubiquitin‐dependent turnover of ER‐stress sensors, proteostasis factors, and apoptotic regulators can recalibrate the apoptotic threshold in colorectal cancer, balancing adaptive survival against terminal cell death. Defining these context‐dependent vulnerabilities may enable strategies that overcome stress adaptation and restore apoptotic competence ...
Jing Hu, Shanliang Zheng, Ying Hu
wiley   +1 more source

Context‐dependent TREM2 signalling in myeloid cells: Molecular mechanisms and immunotherapeutic divergence in neurodegeneration and cancer

Clinical and Translational Medicine, Volume 16, Issue 10, October 2026.
Divergent triggering receptor expressed on myeloid cells 2 (TREM2) signalling pathways instruct myeloid cell adaptation towards neuroprotective disease‐associated microglia (DAM)/lipid‐associated macrophage (LAM) or immunosuppressive tumour‐associated macrophage (TAM) phenotypes.
Yaqing Lv, Mingpeng Shi, Yongfei Zhao, Yi Yu, Jiawei Lv, Hai Zhao   +5 more
wiley   +1 more source

The Porosity and Stiffness of Articular Cartilage Extracellular Matrix Derived Scaffolds Modulate Chondrogenesis of Mesenchymal Stromal Cells

Journal of Biomedical Materials Research Part A, Volume 114, Issue 10, October 2026.
ABSTRACT Articular cartilage (AC) regeneration remains a major challenge in musculoskeletal tissue engineering. Cartilage extracellular matrix (ECM)‐derived scaffolds have shown promise as tissue‐specific biomaterials, but the extent to which the fabrication process can be tuned to modulate scaffold pore architecture and mechanics and how this might ...
Giovanni Gonnella, Tosca Roncada, Daniel J. Kelly   +2 more
wiley   +1 more source

Targeted delivery of anti-inflammatory therapy to rheumatoid tissue by fusion proteins containing an IL-4-linked synovial targeting peptide [PDF]

, 2011
We provide first-time evidence that the synovial endothelium-targeting peptide (SyETP) CKSTHDRLC successfully delivers conjugated IL-4 to human rheumatoid synovium transplanted into SCID mice. SyETP, previously isolated by in vivo phage display and shown
Ciara M. Finucane, Y. K. Stella Man, Danielle DiCara, Rita Jones, Ahuva Nissim, Stephen J. Mather, Taher E. I. Taher, Michele Bombardieri, Costantino Pitzalis, Yuti Chernajovsky, Sarah E. Wythe   +10 more
core  

T‐cell engagers in autoimmune rheumatic diseases: From concept to clinical practice

Clinical and Translational Medicine, Volume 16, Issue 11, November 2026.
Christina Düsing, Andrea‐Hermina Györfi, Jörg H. W. Distler   +2 more
wiley   +1 more source

Patients with cyclops syndrome exhibit elevated synovial fluid interleukin‐6 (IL‐6) and tumor necrosis factor alpha (TNF‐α) levels and disorganized collagen remodelling within the lesion: A histological and molecular study

Journal of Experimental Orthopaedics, Volume 13, Issue 4, October 2026.
A stepwise approach: from tissue biopsies to histological and molecular analysis. Abstract Purpose Cyclops syndrome is a clinically relevant complication of anterior cruciate ligament (ACL) reconstruction characterized by the formation of a fibrotic nodule (cyclops lesion) that causes extension loss and often requires a revision surgery.
Luca Morici, Philippe M. Tscholl, Eline. L. Skau, Klaus Eyer, Lukas Clerc, Morgan Gauthier, Ines Nikolic   +6 more
wiley   +1 more source

Enrichment and Proteomic Profiling of Stromal‐Associated Extracellular Vesicle Subpopulations From Arthritic Synovial Fluid by Size‐Exclusion Chromatography Coupled to CD90‐Directed Immunocapture

Journal of Extracellular Vesicles, Volume 15, Issue 10, October 2026.
Synovial fluid contains heterogeneous EV populations reflecting stromal and immune‐associated cellular inputs from the arthritic joint. SEC‐UF enrichment coupled to CD90‐targeted immunocapture enables recovery of stromal‐associated EV subpopulation from complex patient synovial fluid, while focused LC‐MS/MS and cell‐of‐origin analysis enable molecular ...
Stefanie Kurth, Edveena Hanser, Simone Häner‐Massimi, Stavros Giaglis, Florian Geier, Dominik Burri, Katarzyna Buczak, Ute Heider, Stefan Wild, Yves P. Acklin, Christian Egloff, André N. Tiaden, Diego Kyburz   +12 more
wiley   +1 more source

Extracellular Vesicles: Classification, Biological Functions, Diseases, and Therapeutic Opportunities

MedComm, Volume 7, Issue 10, October 2026.
• EV content maintains cellular homeostasis and is involved in several disease onset and progression. • miRNA export in EVs depends on: RNA‐binding proteins recognizing motif sequences and on epitranscriptomic modifications. • The disclosure of delivery mechanisms is crucial for developing personalized EV‐based therapeutic tools. ABSTRACT Extracellular
Sabrina Garbo, Francesco Marocco, Clemens Zwergel, Marco Tripodi, Cecilia Battistelli   +4 more
wiley   +1 more source

Advancing Rheumatoid Arthritis Synovial Biopsy Analysis: One B Cell at a Time. [PDF]

Arthritis Rheumatol, 2020
Orange DE, Donlin LT.
europepmc   +1 more source

Are synovial biopsies of diagnostic value?

Arthritis research & therapy, 2003
Synovial tissue is readily accessible by closed needle or arthroscopic biopsy. These techniques provide adequate tissue for most diagnostic requirements. Examination of synovial tissue can assist in the diagnosis of some joint infections, and in several atypical or rare synovial disorders.
openaire   +2 more sources