Results 31 to 40 of about 2,392,786 (296)

m6A‐Mediated Glycolysis by IL‐37 Drives T Cell Metabolic Reprogramming to Regulate Colitis

Advanced Science, EarlyView.
This study identifies an IL‐37/SIGIRR‐METTL14 regulatory axis that suppresses global m6A modification in CD4+ T cells. IL‐37 signaling, mediated through SIGIRR, inhibits IRAK4 and JNK phosphorylation, leading to downregulation of the methyltransferase METTL14.
Xiaoyan Wang, Jiadong Yu, Guolin Li, Ya Li, Fanlian Zeng, Jing Hu, Yifan Zhou, Chengcheng Yue, Qixiang Zhao, Chen Zhang, Hong Zhou, Fulei Zhao, Yawen Hu, Pei Zhou, Linna Gu, Yuting Feng, Mingxiang He, Shishi Huang, Xiaochi Sun, Xinmeng Wang, Jie Tang, Xinyu Zeng, Wenling Wu, Nongyu Huang, Xinai Cui, Kaijun Cui, Jiong Li   +26 more
wiley   +1 more source

Characterization of mesenchymal stem cells derived from the equine synovial fluid and membrane

BMC Veterinary Research, 2015
BackgroundIsolation of mesenchymal stem cells (MSCs) in equines, has been reported for different tissues including bone marrow, adipose, umbilical cord, peripheral blood, and yolk sac.
A. A. F. Prado, P. Favaron, L. C. D. Da Silva, R. Baccarin, M. Miglino, D. Maria   +5 more
semanticscholar   +1 more source

Synovial Macrophages: Past Life, Current Situation, and Application in Inflammatory Arthritis

Frontiers in Immunology, 2022
Inflammatory arthritis is an inflammatory disease that involves the joints and surrounding tissues. Synovial hyperplasia often presents when joints become inflamed due to immune cell infiltration.
Lin Bai, Yazhen Su, Xuexue Wang, B. Bai, Cheng-Qiang Zhang, Li-Yun Zhang, Gailian Zhang   +6 more
semanticscholar   +1 more source

Disruption of Treg Homeostasis in Rheumatoid Arthritis via Ferroptosis‐Mediated ETC Collapse and TXK‐STAT3/PLCγ1 Activation

Advanced Science, EarlyView.
In rheumatoid arthritis, synovial Tregs accumulate but are functionally impaired due to iron overload‐induced ferroptosis. This triggers mitochondrial dysfunction and TXK tyrosine kinase‐mediated signaling, leading to Treg destabilization and inflammation.
Jingrong Chen, Xiao Guan, Kexu Xiong, Xiaoyi Shi, Luyao Wu, Chuanxin Su, Jun Zhao, Rongzhen Liang, Huimin Wang, Junlong Dang, Ye Chen, Yiding Xiong, Chi Zhou, Futao Zhao, Zhenhang Zhu, Xiaoli Fan, Li Zhou, Nancy Olsen, Yutong Jiang, Song Guo Zheng   +19 more
wiley   +1 more source

Locally renewing resident synovial macrophages provide a protective barrier for the joint

Nature, 2019
Macrophages are considered to contribute to chronic inflammatory diseases such as rheumatoid arthritis1. However, both the exact origin and the role of macrophages in inflammatory joint disease remain unclear.
S. Culemann, Anika Grüneboom, J. A. Nicolás-Ávila, D. Weidner, Katrin F Lämmle, T. Rothe, J. A. Quintana, Philipp Kirchner, Branislav Krljanac, M. Eberhardt, F. Ferrazzi, Elke Kretzschmar, M. Schicht, Kim Fischer, K. Gelse, Maria Faas, R. Pfeifle, Jochen A. Ackermann, Milena L. Pachowsky, N. Renner, D. Simon, R. Haseloff, A. Ekici, T. Bäuerle, I. Blasig, J. Vera, D. Voehringer, A. Kleyer, F. Paulsen, G. Schett, A. Hidalgo, G. Krönke   +31 more
semanticscholar   +1 more source

Do Synovial Inflammation and Meniscal Degeneration Impact Clinical Outcomes of Patients Undergoing Arthroscopic Partial Meniscectomy? A Histological Study

International Journal of Molecular Sciences, 2022
The menisci exert a prominent role in joint stabilization and in the distribution of mechanical loading. Meniscal damage is associated with increased risk of knee OA. The aim of this study was to characterize the synovial membrane and meniscal tissues in
E. Olivotto, E. Belluzzi, A. Pozzuoli, A. Cigolotti, M. Scioni, S. Goldring, M. Goldring, P. Ruggieri, R. Ramonda, B. Grigolo, G. Trisolino, M. Favero   +11 more
semanticscholar   +1 more source

Cytolytic activity in T cell clones derived from human synovial rheumatoid membrane: inhibition by synovial fluid

, 1990
Summary A panel of T cell clones was derived from the synovial membrane of a patient with rheumatoid arthritis (RA). We investigated whether T cell clones with cytolytic properties were present and whether T cell cytotoxicity was ...
A M M MILTENBURG, J M VAN LAAR, M R DAHA, P DE KUIPER, F C BREEDVELD   +4 more
core   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Nanomedicine Meets Immunotherapy: Advancing Adoptive Cell Therapy with Nanoparticles in the Treatment of Cancer with Sustainability Perspectives

Advanced Science, EarlyView.
This review surveys nanoparticle‐based strategies to enhance adoptive cell therapy, particularly CAR‐T cell approaches, in solid tumor treatment. It describes how nanoparticles can improve tumor immunogenicity and T‐cell infiltration while reducing toxicity, and how they enable in vivo CAR‐T cell generation.
Erica Frostegård, Tatiana Bobrova, Amalie Leinebø, Thibault Leray, Shayamita Ghosh, Lorena García‐Hevia, Chiara Puccinelli, Lorenzo Riccio, Jacopo Sorani, Davide Bonifazi, Julien Caumartin, Emmanuel Donnadieu, Florence Gazeau, Roland Hischier, Else Marit Inderberg, Mónica L. Fanarraga, Maria Loustau, Bernd Nowack, Sébastien Wälchli, Cécilia Ménard‐Moyon   +19 more
wiley   +1 more source

Establishment of a human three-dimensional chip-based chondro-synovial co-culture joint model for reciprocal cross-talk studies in arthritis research

bioRxiv, 2021
Rheumatoid arthritis is characterised by a progressive, intermittent inflammation at the synovial membrane, which ultimately leads to the destruction of the synovial joint.
M. Rothbauer, R. Byrne, S. Schobesberger, I. Olmos Calvo, A. Fischer, E. Reihs, Sarah Spitz, Barbara Bachmann, F. Sevelda, J. Holinka, W. Holnthoner, H. Redl, S. Toegel, R. Windhager, H. Kiener, P. Ertl   +15 more
semanticscholar   +1 more source