Autophagy generates citrullinated peptides in human synoviocytes: a possible trigger for anti-citrullinated peptide antibodies [PDF]
, 2016 OBJECTIVES: Autophagy may represent a functional processing event that creates a substrate for autoreactivity. In particular, autophagy may play a role in the pathogenesis of RA, since autophagy is a key cellular event involved in the generation of ...
Alessandra Nerviani +14 more
core +1 more source
Disuse histological changes of an unloading environment on joint components in rat knee joints
Osteoarthritis and Cartilage Open, 2019 Summary: Objectives: To clarify the effects of mechanical unloading on joint components, including the articular cartilage by knee compartments, synovial membrane, and the infrapatellar fat pad (IFP), using a hindlimb suspension rat model.
Ikufumi Takahashi +3 more
doaj +1 more source
Expression of TLR2, FOXP3, and COX2 in the synovial membrane of dogs with canine leishmaniasis-induced arthritis [PDF]
Pesquisa Veterinária Brasileira: Canine leishmaniasis (CanL) is a multifaceted disease triggered by the protozoan Leishmania infantum, characterized by diverse clinical presentations, including osteoarticular complications.
Flávio C. Souza-Filho +7 more
doaj +1 more source
Immunohistochemical Analysis of IL-1 Receptor 1 In the Discs of Patients with Temporomandibular Joint Dysfunction [PDF]
, 2018 Objective Temporomandibular joint dysfunction (TMD) may affect a patient’s quality of life, and one of the etiologies can be anterior disc displacement with reduction (ADDwR) and anterior disc displacement without reduction (ADDWoR).
Almeida, Luis Eduardo +8 more
core +2 more sources
True infliximab resistance in rheumatoid arthritis: a role for lymphotoxin α? [PDF]
, 2004 Background: The combination of methotrexate and the anti-tumour necrosis factor (TNF) antibody infliximab is a very effective treatment for rheumatoid arthritis (RA). However, a proportion of patients are not responsive to this treatment. Inefficacy may
Bingham, S.J. +5 more
core +2 more sources
The therapeutic potential of the filarial nematode-derived immunodulator, ES-62 in inflammatory disease [PDF]
, 2010 The dramatic recent rise in the incidence of allergic or autoimmune inflammatory diseases in the West has been proposed to reflect the lack of appropriate priming of the immune response by infectious agents such as parasitic worms during childhood ...
Al-Riyami +111 more
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Synovial fluid over the centuries
Reumatismo, 2003 This review deals with the most meaningful historical topics on the study of synovial fluid, by starting from the Greco- Roman Medicine, up to Paracelsus (1493-1541), who introduced the term “synovia” to name the intra-articular humour.
P. Marson
doaj +1 more source
European Journal of Inflammation, 2020 Knee osteoarthritis (KOA) is a common chronic disease in the elderly and leads to a high rate of disability. Du Huo Ji Sheng Tang (DHJST), a Chinese traditional medicinal formula, is a classic prescription for the treatment of KOA.
Wenjin Chen +3 more
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The Crucial Questions on Synovial Biopsy: When, Why, Who, What, Where, and How?
Frontiers in Medicine, 2021 In the majority of joint diseases, changes in the organization of the synovial architecture appear early. Synovial tissue analysis might provide useful information for the diagnosis, especially in atypical and rare joint disorders, and might have a value
Francesca Ingegnoli +11 more
doaj +1 more source