Results 101 to 110 of about 19,285 (227)

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

Advanced Science, Volume 13, Issue 62, 9 November 2026.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng, Linhui Han, Chen Yan, Jialin Li, Kaiqiang Sun, Tianyi Zhao, Jiangang Shi   +9 more
wiley   +1 more source

Alkaloids from the stems of Fissistigma maclurei Merr. inhibit the proliferation of synoviocytes

, 2023
Two new aporphine-derived alkaloids, aporaloids C and D (1 and 2), along with eight known biogenetically related alkaloids (3–10) were isolated from the stems of Fissistigma maclurei Merr.
Guo-Ze Chen (15995893), Chuan-Shan Fu (15995887), Ji-Ling Yi (9973849), Xue-Ming Zhou (1744876), Mu-Tao Liang (15995881), Xiao-Zheng Zhang (15995884), Zi-Hao Chen (10270469), Duo-Jiang Li (15995890)   +7 more
core   +1 more source

Alpinia oxyphylla Miq.: Chemical Constituents, Neuroprotective and Metabolic Effects, and Translational Challenges—A Review of Preclinical Evidence

Food Science &Nutrition, Volume 14, Issue 11, November 2026.
Alpinia oxyphylla Miq. (AOM), a medicinal and edible resource, contains diphenylheptanoids, polysaccharides, flavonoids, terpenoids, and phenolic acids. These constituents exert multi‐target synergistic effects by modulating neuroinflammation, oxidative stress, and the PI3K/Akt pathway, thereby improving Alzheimer's disease, Parkinson's disease, and ...
Ziyan Yang, Hemei Yuan, Dengyou Nie, Jun Sheng, Titi Liu, Huanhuan Xu   +5 more
wiley   +1 more source

Folate deficiency impedes the growth of synoviocytes.

, 2016
(A) HIG-82 synoviocytes (3×104) or (B) HIG-82 synoviocytes (3×105) were plated in 12-well culture plates or 100-mm cultured dishes, respectively, for 24 h.
Jin-Yi Wu (548836), Hung-Chih Hsu (479317), Ching-Hsein Chen (325864), Kai-Hua Chen (570148), Yi-Wen Chuang (570146), Fung-Jou Lu (89259), Rang-Hui Yeh (846085), Wen-Ming Chang (570147), Chin-Chin Huang (846084), Tsan-Zon Liu (479323), Pey-Jium Chang (479322), Chang-Zern Hong (570149)   +11 more
core   +1 more source

Diosgenin, a plant steroid, induces apoptosis in human rheumatoid arthritis synoviocytes with cyclooxygenase-2 overexpression. [PDF]

, 2004
International audienceIn the present study, we have shown for the first time that a plant steroid, diosgenin, causes an inhibition of the growth of fibroblast-like synoviocytes from human rheumatoid arthritis, with apoptosis induction associated with ...
Liagre, Bertrand, Vergne-Salle, Pascale, Bertrand Liagre, Cecile Corbiere, Corbière, Cécile, Jean L Beneytout, Pascale Vergne-Salle, Jean L Charissoux, Charissoux, Jean, Beneytout, Jean   +9 more
core   +1 more source

Estrogen Receptor Expression Changes After Puberty in the Porcine Anterior Cruciate Ligament

Journal of Orthopaedic Research, Volume 44, Issue 11, November 2026.
Schematic highlighting the study design and approach to characterize genetic differences and hormone receptor expression differences between the AM and PL bundles across growth. Pre‐ and post‐pubescent female pigs had their ACLs removed, separated by bundle, and then characterized using gene expression, western blot, and immunofluorescence.
Jacob D. Thompson, Margaret E. Easson, Matthew B. Fisher   +2 more
wiley   +1 more source

Curcumin in the Treatment of Various Diseases: Mechanism of Action, Bioavailability, Therapeutic Effects, and Current Clinical Trials

MedComm, Volume 7, Issue 11, November 2026.
Curcumin, a naturally occurring polyphenol, exhibits significant anti‐inflammatory and antioxidant capabilities. This review elucidates the specific molecular mechanisms by which curcumin exerts therapeutic effects on various diseases, including neurological disorders, cardiovascular diseases, cancers, inflammatory disorders, and autoimmune diseases ...
Lin Wang, Qifei Pan, Wenjuan Long, Xinyao Li, Jianqin Mao, Sitong Zhou, Zihui Wang, Xuelian Zou, Yuqing She, Mingqin Shi, Yang Zhou, Jiarong Du, Zhongyang Hu, Xiaoman Lv, Yishu Chen, Dongdong Qin   +15 more
wiley   +1 more source

Involvement of nuclear factor k B in the regulation of cyclooxygenase-2 expression by interleukin-1 in rheumatoid synoviocytes [PDF]

, 1997
Objective . To evaluate involvement of the transcription factor nuclear factor k B (NF- k B) in the increased expression of cyclooxygenase-2 (COX-2) stimulated by interleukin-1Β (IL-1Β) in primary rheumatoid synoviocytes. Methods .
McCarthy, Conor J., Hla, Timothy, Conor J. Mccarthy, Timothy Hla, Leslie J. Crofford, Crofford, Leslie J., Bing Tan, Tan, Bing   +7 more
core   +1 more source

IFNγ production during cell interactions distinguishes localized from diffuse pigmented villonodular synovitis and rheumatoid arthritis

Arthritis Research & Therapy
Background Pigmented villonodular synovitis (PVNS) is a rare articular disease characterized by aggressive synovial proliferation, with localized or diffuse forms.
Mélissa Noack, Pierre Miossec
doaj   +1 more source

Parenteral CHIKV mRNA Vaccination Reshapes the Gut Microbial, Metabolic, and Immune Landscapes

MedComm, Volume 7, Issue 11, November 2026.
This study provides multi‐omics evidence that parenteral mRNA vaccination against CHIKV, even in the absence of viral infection, can profoundly remodel the host intestinal ecosystem—recapitulating key microbial, metabolic, and GI immune features typically associated with active CHIKV infection, characterized by enrichment of Segatella copri, activation
Hongyu Chen, Wenhao Xie, Yun Yang, Cong Tang, Xiaoming Liang, Yuxia Yuan, Junbin Wang, Yanan Zhou, Hao Yang, Qing Huang, Wenqi Quan, Wenhai Yu, Haixuan Wang, Daoju Wu, Youchun Wang, Shuaiyao Lu   +15 more
wiley   +1 more source