Results 101 to 110 of about 30,224 (276)

Effect of diclofenac etalhyaluronate (SI-613) on the production of high molecular weight sodium hyaluronate in human synoviocytes

BMC Musculoskeletal Disorders, 2019
Background We have reported that a single intra-articular injection of diclofenac etalhyaluronate (SI-613) exerted a potent and long-lasting analgesic effect in experimental arthritis models.
Tomochika Kisukeda, Junichi Onaya, Keiji Yoshioka   +2 more
doaj   +1 more source

Activation of fibroblast-like synoviocytes derived from rheumatoid arthritis via lysophosphatidic acid-lysophosphatidic acid receptor 1 cascade [PDF]

, 2014
INTRODUCTION: Lysophosphatidic acid (LPA) is a bioactive lipid that binds to G protein–coupled receptors (LPA(1–6)). Recently, we reported that abrogation of LPA receptor 1 (LPA(1)) ameliorated murine collagen-induced arthritis, probably via inhibition ...
Chie Miyabe, Chiyoko Sekine, Kazutaka Sugimoto, Masayoshi Harigai, Masayuki Miyasaka, Nobuyuki Miyasaka, Toshihiro Nanki, Waka Yokoyama, Yoshiko Iwai, Yoshishige Miyabe   +9 more
core   +1 more source

Elevated Serum Proadrenomedullin Levels in Rheumatoid Arthritis Versus Spondyloarthritis: Insights From a Biobank Cohort

ACR Open Rheumatology, Volume 8, Issue 5, May 2026.
Objective Proadrenomedullin (pro‐ADM) is a peptide implicated in immunomodulation, with higher levels observed in inflammatory conditions, cardiovascular impairment, and sepsis. Although extensively studied in acute disorders, its potential as a biomarker in inflammatory arthritis remains underexplored.
Nefeli Stavroula Papastathopoulou, Elisa Assirelli, Simona Neri, Susanna Naldi, Jacopo Ciaffi, Luana Mancarella, Veronica Brusi, Lucia Lisi, Federica Pignatti, Piero Ruscitti, Francesco Ursini   +10 more
wiley   +1 more source

Synoviocytes. Autonomous drivers of chronicity?

, 2014
Background: Immunization with Glucose-6-phosphate isomerase (G6PI) induces arthritis in susceptible strains of mice. Depletion of regulatory T cells (Tregs) prior to immunization switches the usually acute, self-limiting course to a non-remitting, destructive arthritis. This provides a possibility to[for full text, please go to the a.m. URL]
Böttcher, M, Schett, G, Falk, C, Irmler, I, Wunrau, C, Korb-Pap, A, Pap, T, Kamradt, T   +7 more
openaire   +2 more sources

Different expression of [béta] subunits of the KCa1.1 channel by invasive and non-invasive human fibroblast-like synoviocytes [PDF]

, 2016
K
Beeton, Christine, Gulko, Pércio S., Huq, Redwan, Laragione, Teresina, Panyi, György, Pethő, Zoltán, Tajhya, Rajeev B., Tanner, Mark R.   +7 more
core   +2 more sources

Plasma Proteomics Identifies Thousand‐and‐One–Amino Acid Kinase 3 as a Potential Biomarker of Rheumatoid Arthritis Activity and a Novel Therapeutic Target

Arthritis &Rheumatology, Volume 78, Issue 5, Page 1045-1061, May 2026.
Objective Bone destruction associated with active rheumatoid arthritis (RA) remains a major therapeutic challenge, with a lack of reliable molecular markers reflecting bone injury. This study aims to identify novel biomarkers linked to bone destruction in active RA through proteomic analysis, providing new strategies for precise monitoring and targeted
Pengfei Xin, Wenzhen Li, Xinyu A, Jun Shen, Xiaohui Meng, Yanqin Bian, Haihui Han, Zheng Xiang, Lei Ran, Songtao Sun, Jun Xie, Tao Yue, Qi Zhu, Xiaoming Zhang, Lu Xie, Lianbo Xiao   +15 more
wiley   +1 more source

Comprehensive epigenetic landscape of rheumatoid arthritis fibroblast-like synoviocytes. [PDF]

, 2018
Epigenetics contributes to the pathogenesis of immune-mediated diseases like rheumatoid arthritis (RA). Here we show the first comprehensive epigenomic characterization of RA fibroblast-like synoviocytes (FLS), including histone modifications (H3K27ac ...
Ai, Rizi, Ainsworth, Richard I, Bachman, Kurtis E, Bai, Yuchen, Boyle, David L, Ding, Bo, Firestein, Gary S, Gulko, Percio S, Hammaker, Deepa, Krishna, Vinod, Laragione, Teresina, Maeshima, Keisuke, Nagpal, Sunil, Palescandolo, Emanuele, Pocalyko, David, Wang, Mengchi, Wang, Wei, Whitaker, John W, Wildberg, Andre   +18 more
core   +2 more sources

Macrophage‐Targeting Biomaterials for Osteoarthritis Therapy

Journal of Biomedical Materials Research Part A, Volume 114, Issue 5, May 2026.
Macrophage‐Targeting Biomaterials for Osteoarthritis Therapy. Created in BioRender. Jain, E. (2026) https://BioRender.com/x4f9o8g. ABSTRACT Osteoarthritis (OA) is a highly prevalent, disabling, and painful disease of the joints, characterized by progressive cartilage degeneration, synovial fibrosis, and pain.
Era Jain, Paul Nana Kwame Sagoe
wiley   +1 more source

Hydroxychloroquine potentiates Fas-mediated apoptosis of rheumatoid synoviocytes

Clinical and Experimental Immunology, 2006
SummaryInadequate apoptosis may contribute to the synovial hyperplasia associated with rheumatoid arthritis (RA). The Fas-associated death domain protein (FADD)-like interleukin (IL)-1β-converting enzyme (FLICE)-inhibitory protein (FLIP), which is an apoptotic inhibitor, has been implicated in the resistance to Fas-mediated apoptosis of synoviocytes ...
W-U, Kim, S-A, Yoo, S-Y, Min, S-H, Park, H-S, Koh, S-W, Song, C-S, Cho   +6 more
openaire   +3 more sources

Extracellular Vesicles in Osteoarthritis: From Pathogenic Mediators to Engineered Therapeutics in a Precision Medicine Roadmap

Journal of Extracellular Biology, Volume 5, Issue 5, May 2026.
ABSTRACT Osteoarthritis (OA) remains without disease‐modifying sssstherapies, in part due to biological heterogeneity and a hostile joint microenvironment that undermines one‐size‐fits‐all interventions. Extracellular vesicles (EVs) play a dual role in OA pathophysiology: endogenous EVs disseminate pro‐inflammatory and catabolic signals that propagate ...
Duc‐Hiep Bach, Van Giang Bui, Thanh Liem Nguyen   +2 more
wiley   +1 more source