Results 111 to 120 of about 30,224 (276)

Targeted delivery of anti-inflammatory therapy to rheumatoid tissue by fusion proteins containing an IL-4-linked synovial targeting peptide [PDF]

, 2011
We provide first-time evidence that the synovial endothelium-targeting peptide (SyETP) CKSTHDRLC successfully delivers conjugated IL-4 to human rheumatoid synovium transplanted into SCID mice. SyETP, previously isolated by in vivo phage display and shown
Ahuva Nissim, Ciara M. Finucane, Costantino Pitzalis, Danielle DiCara, Michele Bombardieri, Rita Jones, Sarah E. Wythe, Stephen J. Mather, Taher E. I. Taher, Y. K. Stella Man, Yuti Chernajovsky   +10 more
core   +1 more source

Proteomic analysis of synovial tissue in rheumatoid arthritis, OLFM4 promotes fibroblast like synoviocytes proliferation in RA [PDF]

, 2020
Xiaoyu Ren, Ke Xu, Jing Xu, Manman Geng, Chao Lu, Linbo Kong, Yongsong Cai, Weikun Hou, Yufeng Lu, Yirixiati Aihaiti, Ru Wang, Peng Xu   +11 more
openalex   +1 more source

RNA Modifications: Current Understandings and Future Perspectives

MedComm, Volume 7, Issue 5, May 2026.
Types of RNA modification. We have summarized the currently common types of RNA modifications, including ac4C, m6A, m1A, m5C, m3C, m7G, and ψ, and visually characterized their features through structural formulas. The characteristic structures are marked with a background color different from the background color.
Shiyu Xiao, Tingwen Xiang, Chuan Yang, Xiaohua Wang, Gang Huang, Fei Luo, Zhao Xie, Yueqi Chen   +7 more
wiley   +1 more source

Signal Transduction of Inflammatory Synoviocytes in Rheumatoid Arthritis

YAKUGAKU ZASSHI, 2008
Recent advances in post-genomic technology enable us to analyze gene expression and protein modification comprehensively in tissues and cells, resulting in new developments in the analysis of molecular events of diseases. We have been studying the pathogenic and progressive mechanisms of diseases from the aspect of signalling pathways of cells ...
Hiroki, Mori, Tohru, Nakanishi
openaire   +3 more sources

MRI features of an intra‐articular histiocytic sarcoma affecting the stifle joint in a dog

Veterinary Record Case Reports, Volume 14, Issue 2, May 2026.
Abstract A 13‐year‐old, spayed, female German shorthaired pointer was presented for investigation of a right pelvic limb lameness and associated marked stifle swelling. Magnetic resonance imaging revealed a mildly heterogeneous, T2‐weighted hyperintense and T1‐weighted homogeneously hypointense, contrast‐enhancing fine nodular mass arising from the ...
Harriet Rhodes, Thorsten Rick, Joni Viitanen   +2 more
wiley   +1 more source

Abnormal Expression of DICER1 Leads to Dysregulation of Inflammatory Effectors in Human Synoviocytes

Mediators of Inflammation, 2019
Dysregulation of multiple microRNAs widely takes place during rheumatoid arthritis (RA) and experimental arthritides. This study is performed to explore the possible mechanism underlying DICER1 deficiency-mediated inflammation in human synoviocytes SW982.
Congshan Jiang, Jing Xu, Wenhua Zhu, Yongsong Cai, Si Wang, Yuanxu Guo, Ke Xu, Manman Geng, Nazim Hussain, Yan Han, Fujun Zhang, Qilan Ning, Liesu Meng, Shemin Lu   +13 more
doaj   +1 more source

FOXC1‐ATP7A Axis Activates PI3K/AKT Signaling to Suppress Cuproptosis and Drive Fibroblast Pathogenesis in Rheumatoid Arthritis

The FASEB Journal, Volume 40, Issue 8, 30 April 2026.
This graphical abstract illustrates the regulatory mechanism of the FOXC1‐ATP7A axis in Rheumatoid Arthritis (RA). Bioinformatics analysis identifies FOXC1 as a hub transcription factor that is significantly upregulated in RA synovial tissues and fibroblast‐like synoviocytes (FLSs).
Daomin Lu, Fang Tang, Zong Jiang, Wukai Ma, Changming Chen, Lei Hou, Qianwei Lu, Xueming Yao, Danyang Li, Weiya Lan   +9 more
wiley   +1 more source

Adrenal Steroids Modulate Fibroblast-Like Synoviocytes Response During B. abortus Infection

Frontiers in Endocrinology, 2019
Brucella abortus stimulates an inflammatory immune response that stimulates the endocrine system, inducing the secretion of dehydroepiandrosterone (DHEA) and cortisol. In humans, the active disease is generally present as osteoarticular brucellosis.
María Virginia Gentilini, Guillermo Hernán Giambartolomei, María Victoria Delpino   +2 more
doaj   +1 more source

The JAK inhibitor tofacitinib suppresses synovial JAK1-STAT signalling in rheumatoid arthritis. [PDF]

, 2015
ObjectiveTofacitinib is an oral Janus kinase (JAK) inhibitor for the treatment of rheumatoid arthritis (RA). The pathways affected by tofacitinib and the effects on gene expression in situ are unknown.
Boyle, DL, Bradley, J, Firestein, GS, Hodge, J, Kaplan, I, Kavanaugh, A, Krishnaswami, S, Luo, Z, Mandel, D, Mease, P, Rosengren, S, Shurmur, R, Singhal, AK, Soma, K, Wei, N   +14 more
core  

Alterations in the self-renewal and differentiation ability of bone marrow mesenchymal stem cells in a mouse model of rheumatoid arthritis [PDF]

, 2010
Introduction: Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease primarily involving the synovium. Evidence in recent years has suggested that the bone marrow (BM) may be involved, and may even be the initiating site of the disease ...
Bellantuono, I., Coulton, L., Croucher, P.I., Gambardella, A., Hughes, D., Kottam, L., Mohanty, S.T., Nicklin, M.J., Wilson, A.G.   +8 more
core   +3 more sources