Results 141 to 150 of about 13,926 (184)

Potential role of mitochondria in synoviocytes

Clinical Rheumatology, 2020
Synoviocytes are located in the synovium lining layer, which is composed of macrophage-like synoviocytes (MLS) and fibroblast-like synoviocytes (FLS) with different characteristics. Mitochondria, which exist in most cells, are two membrane-covered organelles.
Xuling Luo, Xin Long, Zhiwei Chen
exaly   +3 more sources

Activation of synoviocytes

Current Opinion in Rheumatology, 2000
The evaluation of molecular pathways has revealed various novel insights into rheumatoid arthritis pathophysiology during the past year. In addition, there is an increasing tendency toward analysis not merely of a single mechanism but rather of data addressing a substantial part of the cascade of events leading to cellular activation.
U, Müller-Ladner, R E, Gay, S, Gay
openaire   +2 more sources

Early synovitis—Synoviocytes and mononuclear cells

Seminars in Arthritis and Rheumatism, 1994
Immunohistological observations of synovial tissues obtained at the onset of rheumatoid arthritis (RA) are limited and often reflect the diagnostic confusion inherent in any study of early synovitis. However, a critical analysis of published information and the authors' experience allow certain preliminary conclusions.
N J, Zvaifler, D, Boyle, G S, Firestein
openaire   +2 more sources

Wnt signaling in rheumatoid synoviocyte activation

Modern Rheumatology, 2002
Abstract Rheumatoid arthritis (RA) is a joint-specific disease with complex pathogenesis. It is characterized by synovial inflammation, cartilage loss, and joint destruction. The reasons why joint damage recurs when therapy is discontinued are not clearly understood. Several lines of evidence suggest that cartilage damage is promoted by the transformed
M, Sen, D A, Carson
openaire   +2 more sources

Fibroblast-like Synoviocytes – Actors in Osteoimmunology

Osteologie, 2021
AbstractRheumatoid arthritis (RA) is an immune mediated inflammatory disease (IMID), characterized by chronic inflammation and irreversible bone loss. Studies have shown that fibroblast-like synoviocytes (FLS), a key cell population in the pathogenesis of RA, have an impact on balancing bone ...
Denise Beckmann, Adelheid Korb-Pap, Corinna Wehmeyer   +2 more
openaire   +1 more source

Endothelin-1 Production by Human Synoviocytes

Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, 1998
Immunoreactive (ir)-endothelin (ET)-l concentrations in serum samples and synovial fluids from patients with rheumatoid arthritis were higher than concentrations in sera obtained from healthy volunteers. No significant difference in ir-ET-1 concentrations in synovial fluid was observed between rheumatoid arthritis patients and osteoarthritis patients.
H, Yoshida, Y, Imafuku, M, Ohhara, M, Miyata, R, Kasukawa, K, Ohsumi, J, Horiuchi   +6 more
openaire   +2 more sources

Human rheumatoid synoviocytes express functional P2X7 receptors

Journal of Molecular Medicine, 2008
Human type B synoviocytes are involved in joint injury during rheumatic diseases by producing inflammatory mediators such as interleukin-6 (IL-6). The increased level of purine and pirimidine nucleotides in the synovial fluid of rheumatoid arthritis (RA) patients could activate the large family of P2 receptors.
Caporali, F., Capecchi, PIER LEOPOLDO, Gamberucci, Alessandra, Lazzerini, PIETRO ENEA, Pompella, G., Natale, M., Lorenzini, S., Selvi, E., Galeazzi, Mauro, LAGHI PASINI, Franco   +9 more
openaire   +4 more sources

TLRs Play Crucial Roles in Regulating RA Synoviocyte

Endocrine, Metabolic & Immune Disorders - Drug Targets, 2020
Rheumatoid arthritis (RA) is an autoimmune inflammatory disease comparing the inflammation of synovium. Macrophage-like synoviocytes and fibroblast-like synoviocytes (synoviocytes) are crucial ingredients of synovium. Therein, a lot of research has focused on synoviocytes.
Xuling Luo, Juncheng Cui, Xin Long, Zhiwei Chen   +3 more
openaire   +2 more sources

Chondroid Synoviocytic Neoplasm: A Clinicopathologic, Immunohistochemical, and Molecular Genetic Study of a Distinctive Tumor of Synoviocytes

Modern Pathology
Tumors resembling tenosynovial giant cell tumor (TGCT) but additionally forming chondroid matrix are rare and most often involve the temporomandibular joint (TMJ). We studied 21 tumors consisting of synoviocytes (large, eosinophilic mononuclear cells containing hemosiderin) and chondroid matrix to better understand these unusual neoplasms.
Erica Y. Kao, Fisun Ardic, Numrah Fadra, Jessica D. Hohenstein, Rohini Mopuri, Doris E. Wenger, Lukas Streich, Lisa M. Hines, Andrew L. Folpe   +8 more
openaire   +2 more sources