Results 21 to 30 of about 58,561 (288)

Structural changes in the distal articular end of the femur in experimental modeling of osteomyelitis

Гений oртопедии, 2023
Features of structural changes in the joint components (synovial membrane, articular cartilage, subchondral bone) under the conditions of adjacent limb segment osteomyelitis are poorly understood and require thorough histological studies.
Evgeny N. Ovchinnikov, Tatyana A. Stupina, Olga V. Dyuryagina, Nadezhda V. Kubrak, Yulia A. Stupina   +4 more
doaj   +1 more source

Cross-Tissue Transcriptomic Analysis Leveraging Machine Learning Approaches Identifies New Biomarkers for Rheumatoid Arthritis

Frontiers in Immunology, 2021
There is an urgent need to identify biomarkers for diagnosis and disease activity monitoring in rheumatoid arthritis (RA). We leveraged publicly available microarray gene expression data in the NCBI GEO database for whole blood (N=1,885) and synovial (N ...
Dmitry Rychkov, Dmitry Rychkov, Dmitry Rychkov, Jessica Neely, Tomiko Oskotsky, Steven Yu, Steven Yu, Noah Perlmutter, Joanne Nititham, Alexander Carvidi, Melissa Krueger, Andrew Gross, Lindsey A. Criswell, Lindsey A. Criswell, Lindsey A. Criswell, Lindsey A. Criswell, Judith F. Ashouri, Marina Sirota, Marina Sirota   +18 more
doaj   +1 more source

The liver X receptor pathway is highly upregulated in rheumatoid arthritis synovial macrophages and potentiates TLR-driven cytokine release [PDF]

, 2013
<p>Objectives: Macrophages are central to the inflammatory processes driving rheumatoid arthritis (RA) synovitis. The molecular pathways that are induced in synovial macrophages and thereby promote RA disease pathology remain poorly understood.</
Ananth, Antoniv, Asquith, Asquith, Baeten, Bresnihan, Darren Lee Asquith, Enevold, Feldmann, Fontaine, Gerlag, Haringman, He, Huang, Iain B McInnes, Iwahashi, J Alastair Gracie, Jagtar Singh Nijjar, Jahangier, James H Reilly, Janowski, Kauffmann, Kinne, Koch, Long, Lucy E Ballantine, Manhal Khuder Makdasy, Mariola Kurowska-Stolarska, Mulherin, Ospelt, Pamela B Wright, Radstake, Ridley, Sabina Patel, Sack, Sacre, Sattar, Shauna Kerr, Tamaki, van der Heijden, van Halm, van Sijl, Zhao   +42 more
core   +1 more source

Fibrous Synovium Releases Higher Numbers of Mesenchymal Stem Cells Than Adipose Synovium in a Suspended Synovium Culture Model [PDF]

Arthroscopy: The Journal of Arthroscopic & Related Surgery, 2017
To develop an in vitro model, the "suspended synovium culture model," to demonstrate the mobilization of mesenchymal stem cells (MSCs) from the synovium into a noncontacted culture dish through culture medium. In addition, to examine which synovium, fibrous synovium or adipose synovium, released more MSCs in the knee with osteoarthritis.Human synovial ...
Katagiri, Kenta, Matsukura, Yu, Muneta, Takeshi, Ozeki, Nobutake, Mizuno, Mitsuru, Katano, Hisako, Sekiya, Ichiro   +6 more
openaire   +2 more sources

Rituximab versus tocilizumab and B-cell status in TNF-alpha inadequate-responder rheumatoid arthritis patients: the R4-RA RCT

Efficacy and Mechanism Evaluation, 2022
Background: Although biological therapies have transformed the outlook for those with rheumatoid arthritis, there is a lack of any meaningful response in approximately 40% of patients.
Frances Humby, Patrick Durez, Maya H Buch, Myles J Lewis, Michele Bombardieri, Christopher John, Hasan Rizvi, Louise Warren, Joanna Peel, Liliane Fossati-Jimack, Rebecca E Hands, Giovanni Giorli, Felice Rivellese, Juan D Cañete, Peter C Taylor, Peter Sasieni, João E Fonseca, Ernest Choy, Costantino Pitzalis   +18 more
doaj   +1 more source

Role of shear wave elastography of synovium to differentiate rheumatoid and tubercular arthritis

Journal of Medical Ultrasound, 2022
Background: Synovitis is the underlying pathology in various arthritis, and sometimes, it is difficult to differentiate various arthritis clinically or even by imaging.
Karamvir Chandel, Mahesh Prakash, Anindita Sinha, Aman Sharma, Devendra K Chouhan, Manavjit Singh Sandhu   +5 more
doaj   +1 more source

Addition of High Molecular Weight Hyaluronic Acid to Fibroblast-Like Stromal Cells Modulates Endogenous Hyaluronic Acid Metabolism and Enhances Proteolytic Processing and Secretion of Versican

Cells, 2020
We have examined the effect of exogenous linear chain high molecular weight hyaluronic acid (HMW HA) on endogenously synthesized hyaluronic acid (HA) and associated binding proteins in primary cultures of fibroblast-like stromal cells that were obtained ...
Jiapeng Xue, Jinnan Chen, Quan Shen, Deva Chan, Jun Li, Adam P. Tanguay, Tannin A. Schmidt, Faizan Niazi, Anna Plaas   +8 more
doaj   +1 more source

Adipose derived Stromal Vascular Fraction (SVF) cells in the treatment of rheumatoid arthritis of the hand: a 2-year follow-up study [PDF]

CellR4, 2019
OBJECTIVE: Rheumatoid arthritis of the hand constitutes a debilitating aspect of this chronic autoimmune disease. Conventional management with medication is difficult with many side effects. The anti-inflammatory properties of autologous stromal vascular
M. Carstens, J. Montenegro, A. Gómez, D. Correa   +3 more
doaj   +1 more source

The role of proteases in pathologies of the synovial joint [PDF]

, 2008
Synovial (diarthrodial) joints are employed within the body to provide skeletal mobility and have a characteristic structure adapted to provide a smooth almost frictionless surface for articulation.
Buttle, D, Jones, GC, Riley, GP
core   +1 more source

Eucommia ulmoides Polysaccharides Attenuate Rabbit Osteoarthritis by Regulating the Function of Macrophages

Frontiers in Pharmacology, 2021
Background and purpose:Eucommia ulmoides polysaccharides (EUP) can regulate the immunity of macrophages, but the functional status of macrophages is related to osteoarthritis and synovial inflammation.
Yaqiong Sun, Kui Huang, Linhai Mo, Akhlaq Ahmad, Dejia Wang, Zijie Rong, Honghui Peng, Honghua Cai, Guihua Liu   +8 more
doaj   +1 more source