Results 121 to 130 of about 9,706,454 (336)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Chance in the Modern Synthesis [PDF]

, 2016
The modern synthesis in evolutionary biology is taken to be that period in which a consensus developed among biologists about the major causes of evolution, a consensus that informed research in evolutionary biology for at ...
Matthews, Lucas John, Molter, Dan, Plutynski, Anya, Vernon, Kenneth Blake   +3 more
core  

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Entry to 2-aminoprolines via electrochemical decarboxylative amidation of N‑acetylamino malonic acid monoesters

Beilstein Journal of Organic Chemistry
The electrochemical synthesis of 2-aminoprolines based on anodic decarboxylation–intramolecular amidation of readily available N-acetylamino malonic acid monoesters is reported. The decarboxylative amidation under Hofer–Moest reaction conditions proceeds
Olesja Koleda, Janis Sadauskis, Darja Antonenko, Edvards Janis Treijs, Raivis Davis Steberis, Edgars Suna   +5 more
doaj   +1 more source

Hybrid materials for the removal of emerging pollutants in water: classification, synthesis, and properties

, 2022
Monica Rigoletto, Paola Calza, Elisa Gaggero, Enzo Laurenti   +3 more
openalex   +1 more source

Bridging high-level synthesis to RTL technology libraries [PDF]

, 1991
The output of high-level synthesis typically consists of a netlist of generic RTL components and a state sequencing table. While module generators and logic synthesis tools can be used to map RTL components into standard cells or layout geometries, they ...
Dutt, Nikil D., Kipps, James R.
core  

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Three-dimensional covalent organic frameworks with nia nets for efficient separation of benzene/cyclohexane mixtures

Nature Communications
The synthesis of three-dimensional covalent organic frameworks with highly connected building blocks presents a significant challenge. In this study, we report two 3D COFs with the nia topology, named JUC-641 and JUC-642, by introducing planar hexagonal ...
Jianhong Chang, Fengqian Chen, Hui Li, Jinquan Suo, Haorui Zheng, Jie Zhang, Zitao Wang, Liangkui Zhu, Valentin Valtchev, Shilun Qiu, Qianrong Fang   +10 more
doaj   +1 more source

Copper(II) complexes with fluorinated 5-aryl-2,2’-bipyridine-6(6’)-carboxylic acid tridentate ligands

Chimica Techno Acta
Three Cu(II) complexes containing (poly)fluorine ligands based on 5-aryl-2,2’-bipyridine-6(6’)-carboxylic acids have been synthesized for the first time. These complexes belong to either triclinic (P-1) or orthorhombic (Iba2) crystal systems. The packing
Timofey D. Moseev, Mikhail V. Varaksin, Alexey P. Krinochkin, Maria A. Valieva, Ekaterina A. Kudryashova, Yulia M. Sayfutdinova, Anastasiya V. Rybakova, Dmitry S. Kopchuk, Grigory V. Zyryanov, Youcef Ballou, Pavel A. Slepukhin, Vasiliy S. Gaviko, Valery N. Charushin, Oleg N. Chupakhin   +13 more
doaj   +1 more source

Erratum: Axonal mRNA localization and local protein synthesis in nervous system assembly, maintenance and repair [PDF]

, 2012
Hosung Jung, Byung Chul Yoon, Christine E. Holt   +2 more
openalex   +1 more source