Results 131 to 140 of about 12,982,812 (373)

Efficient Assembly of Threaded Molecular Machines for Sequence-Specific Synthesis [PDF]

, 2014
Guillaume De Bo, Sonja Kuschel, David A. Leigh, Bartosz Lewandowski, Marcus Papmeyer, John W. Ward   +5 more
openalex   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Copper(II) complexes with fluorinated 5-aryl-2,2’-bipyridine-6(6’)-carboxylic acid tridentate ligands

Chimica Techno Acta
Three Cu(II) complexes containing (poly)fluorine ligands based on 5-aryl-2,2’-bipyridine-6(6’)-carboxylic acids have been synthesized for the first time. These complexes belong to either triclinic (P-1) or orthorhombic (Iba2) crystal systems. The packing
Timofey D. Moseev, Mikhail V. Varaksin, Alexey P. Krinochkin, Maria A. Valieva, Ekaterina A. Kudryashova, Yulia M. Sayfutdinova, Anastasiya V. Rybakova, Dmitry S. Kopchuk, Grigory V. Zyryanov, Youcef Ballou, Pavel A. Slepukhin, Vasiliy S. Gaviko, Valery N. Charushin, Oleg N. Chupakhin   +13 more
doaj   +1 more source

Quantitative analyses of genes associated with mucin synthesis of broiler chickens with induced necrotic enteritis [PDF]

, 2012
Rebecca E. A. Forder, G. S. Nattrass, Mark S. Geier, Robert Hughes, PI Hynd   +4 more
openalex   +1 more source

Machine learning assisted synthesis of lithium-ion batteries cathode materials

, 2022
Chi Hao Liow, Hyeonmuk Kang, Seung-Gu Kim, Moony Na, Yong‐Ju Lee, Arthur Baucour, Kihoon Bang, Yoonsu Shim, Jacob Choe, Gyuseong Hwang, Seongwoo Cho, Gun Park, Jiwon Yeom, Joshua Agar, Jong Min Yuk, Jonghwa Shin, Hyuck Mo Lee, Hye Ryung Byon, EunAe Cho, Seungbum Hong   +19 more
openalex   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Entry to 2-aminoprolines via electrochemical decarboxylative amidation of N‑acetylamino malonic acid monoesters

Beilstein Journal of Organic Chemistry
The electrochemical synthesis of 2-aminoprolines based on anodic decarboxylation–intramolecular amidation of readily available N-acetylamino malonic acid monoesters is reported. The decarboxylative amidation under Hofer–Moest reaction conditions proceeds
Olesja Koleda, Janis Sadauskis, Darja Antonenko, Edvards Janis Treijs, Raivis Davis Steberis, Edgars Suna   +5 more
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Three-dimensional covalent organic frameworks with nia nets for efficient separation of benzene/cyclohexane mixtures

Nature Communications
The synthesis of three-dimensional covalent organic frameworks with highly connected building blocks presents a significant challenge. In this study, we report two 3D COFs with the nia topology, named JUC-641 and JUC-642, by introducing planar hexagonal ...
Jianhong Chang, Fengqian Chen, Hui Li, Jinquan Suo, Haorui Zheng, Jie Zhang, Zitao Wang, Liangkui Zhu, Valentin Valtchev, Shilun Qiu, Qianrong Fang   +10 more
doaj   +1 more source