Results 91 to 100 of about 4,799,167 (393)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Replicating the Synthetic LBD with German Establishment Data [PDF]

, 2013
One major criticism against the use of synthetic data has been that the efforts necessary to generate useful synthetic data are so intense that many statistical agencies cannot afford them. However, we argue in this paper that the field is still evolving
Drechsler, Jörg, Vilhuber, Lars
core   +1 more source

Modeling Camera Effects to Improve Visual Learning from Synthetic Data

, 2018
Recent work has focused on generating synthetic imagery to increase the size and variability of training data for learning visual tasks in urban scenes.
A Andreopoulos, A Foi, C Kanan, H Cheong, HC Karaimer, MD Grossberg, O Ronneberger, RS Hunter, S Annadurai, SA Bhukhanwala, SR Richter   +10 more
core   +1 more source

Double-Stranded RNA Attenuates the Barrier Function of Human Pulmonary Artery Endothelial Cells [PDF]

, 2013
Circulating RNA may result from excessive cell damage or acute viral infection and can interact with vascular endothelial cells. Despite the obvious clinical implications associated with the presence of circulating RNA, its pathological effects on ...
A Shibamiya, A Siflinger-Birnboim, AA Birukova, AK Cardozo, Akos Heinemann, AM Lundberg, Andrea Olschewski, Attila G. Végh, B Nilius, BE Dewi, BL Jacobs, C Caspersen, C Kannemeier, C Tiruppathi, Chandran Nagaraj, Csilla Fazakas, D Torres, Diana Zabini, ET Chiang, F Aeffner, G Grynkiewicz, GM Cheng, GU Ahmmed, György Váró, Horst Olschewski, HT Ma, I Khan, I Wilhelm, Imola Wilhelm, István A. Krizbai, J Tissari, JL Harcourt, L Fischer, L Liu, M Auer-Grumbach, M Schroder, MM Szewczyk, N Pirher, NC Stowell, O Dellis, P Kumar, PR Cooper, R Malli, R Malli, R O’Callaghan, R Ross, R Sutliff, Rory Edward Morty, S Akira, S Fischer, S Fischer, S Sarkar, S Zimmer, TG Ksiazek, TM Moore, V Konya, VA Londhe, Viktoria Konya, Y Tsuji, Z Balint, Zoltán Bálint   +60 more
core   +3 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

FEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

Synthetic dimensions in ultracold molecules: quantum strings and membranes

, 2018
Synthetic dimensions alter one of the most fundamental properties in nature, the dimension of space. They allow, for example, a real three-dimensional system to act as effectively four-dimensional.
Gadway, Bryce, Hazzard, Kaden R. A., Sundar, Bhuvanesh   +2 more
core   +2 more sources

The bridge between classical and ‘synthetic’/chemical psychoses: towards a clinical, psychopathological and therapeutic perspective [PDF]

, 2019
© 2019 Orsolini, Chiappini, Papanti, De Berardis, Corkery and Schifano. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
Chiappini, Stephania, Corkery, John Martin, De Berardis, Domenico, Orsolini, Laura, Papanti, Duccio, Schifano, Fabrizio   +5 more
core   +2 more sources

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source