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Principles of synthetic biology [PDF]
Essays in Biochemistry, 2021 Abstract In synthetic biology, biological cells and processes are dismantled and reassembled to make novel systems that do useful things. Designs are encoded by deoxyribonucleic acid (DNA); DNA makes biological (bio-)parts; bioparts are combined to make devices; devices are built into biological systems.
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Inducible expression of large gRNA arrays for multiplexed CRISPRai applications
Nature Communications, 2022 CRISPR gene activation and inhibition has become a powerful synthetic tool for influencing the expression of native genes for foundational studies, cellular reprograming, and metabolic engineering.
William M. Shaw +7 more
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Org. Biomol. Chem., 2010 There is currently much excitement surrounding the rapidly growing discipline of synthetic biology, which utilizes the design and construction principles of engineering to develop, evolve and standardize biological components and systems. This systematic approach to improving and increasing the programmability and robustness of biological components is
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“Cell-Free Synthetic Biology”: Synthetic Biology Meets Cell-Free Protein Synthesis
Methods and Protocols, 2019 Since Nirenberg and Matthaei used cell-free protein synthesis (CFPS) to elucidate the genetic code in the early 1960s [...]
Seok Hoon Hong
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Synthetic biology, engineering biology, market expectation
Engineering Biology, 2020 ‘Engineering biology’ is being increasingly adopted as a term by organisations that seek to deliver benefits from ‘synthetic biology’. However, are ‘engineering biology’ and ‘synthetic biology’ different words with the same meaning or do they signal ...
Lionel Clarke
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Nature Communications, 2022 Secreted proteins, such as hormones or cytokines, are key mediators in multicellular organisms. Here the authors present two genetically encoded orthogonal regulatory secretion systems that enables inducible protein release and construction of logic ...
Arne Praznik +8 more
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Microbial Cell Factories, 2022 The inclusion of biosafety strategies into strain engineering pipelines is crucial for safe-by-design biobased processes. This in turn might enable a more rapid regulatory acceptance of bioengineered organisms in both industrial and environmental ...
Enrique Asin-Garcia +5 more
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Molecular and biochemical characterization of a novel isoprene synthase from Metrosideros polymorpha
BMC Plant Biology, 2018 Background Isoprene is a five-carbon chemical that is an important starting material for the synthesis of rubber, elastomers, and medicines. Although many plants produce huge amounts of isoprene, it is very difficult to obtain isoprene directly from ...
Soo-Jin Yeom +8 more
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Microbial Cell Factories, 2023 Background Pseudomonas putida has received increasing interest as a cell factory due to its remarkable features such as fast growth, a versatile and robust metabolism, an extensive genetic toolbox and its high tolerance to oxidative stress and toxic ...
Lyon Bruinsma +6 more
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Engineering consortia by polymeric microbial swarmbots
Nature Communications, 2022 Most attempts to co-cultivate the artificial microbial communities fail mostly due to the mismatched rates of consumption and production of nutrients among subpopulations. Here, the authors develop a microbial swarmbot mediated spatial segregation method
Lin Wang +15 more
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