Results 51 to 60 of about 484,138 (208)

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

Pictures of Synthetic Biology: A reflective discussion of the representation of Synthetic Biology (SB) in the German-language media and by SB experts [PDF]

, 2009
This article is concerned with the representation of Synthetic Biology in the media and by biotechnology experts. An analysis was made of German-language media articles published between 2004 and 2008, and interviews with biotechnology-experts at the ...
Alexandra Seiringer, Amelie Cserer, B Latour, BG Glaser, E Keller-Fox, E Martin, J Boldt, J Caputi, J Hampel, J Hampel, S Hall, U Dahinden   +11 more
core   +2 more sources

Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis

FEBS Letters, EarlyView.
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner, Juthamas Khamseekaew, M. Gregor Madej, Linda Geiges, Bardha Azemi, Christine Ziegler, Christoph Korbmacher, Alexandr V. Ilyaskin   +7 more
wiley   +1 more source

Tales of Emergence - Synthetic Biology as a Scientific Community in the Making [PDF]

, 2009
International audienceThis article locates the beginnings of a synthetic biology network and thereby probes the formation of a potential disciplinary community.
A Balmer, A Pickering, A Pottage, AM Hedgecoe, B Latour, B Latour, B Simpson, C Coenen, CM Mody, D Endy, D Vinck, E Wenger, F Lentzos, GE Marcus, H Becker, HM Collins, I Hacking, J Calvert, J Calvert, J Dupre, J Lave, J Law, JF Conway, JH Fujimura, K Hetherington, K Knorr-Cetina, M Callon, M Dubois, M Greener, M Meyer, M Meyer, MA O'Malley, MC Roco, Morgan Meyer, N Brown, P Collins, PL Galison, R Lamb, S Molyneux-Hodgson, SA Benner, SM Hodgson, SM Hodgson, Susan Molyneux-Hodgson, T Pinch, U Felt, Y Gingras   +45 more
core   +4 more sources

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Is synthetic biology mechanical biology?

History and Philosophy of the Life Sciences, 2015
A widespread and influential characterization of synthetic biology emphasizes that synthetic biology is the application of engineering principles to living systems. Furthermore, there is a strong tendency to express the engineering approach to organisms in terms of what seems to be an ontological claim: organisms are machines.
openaire   +4 more sources

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

FEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang, Frans Bianchi, Geert van den Bogaart   +2 more
wiley   +1 more source

A Molecular Implementation of the Least Mean Squares Estimator

, 2017
In order to function reliably, synthetic molecular circuits require mechanisms that allow them to adapt to environmental disturbances. Least mean squares (LMS) schemes, such as commonly encountered in signal processing and control, provide a powerful ...
Khammash, Mustafa, Zechner, Christoph
core   +1 more source

Plant chemical genetics : from phenotype-based screens to synthetic biology [PDF]

, 2017
The treatment of a biological system with small molecules to specifically perturb cellular functions is commonly referred to as chemical biology. Small molecules are used commercially as drugs, herbicides, and fungicides in different systems, but in ...
Dejonghe, Wim, Russinova, Eugenia
core   +3 more sources

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source