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Synthetic Biology: A Bridge between Artificial and Natural Cells. [PDF]

open access: yes, 2014
Artificial cells are simple cell-like entities that possess certain properties of natural cells. In general, artificial cells are constructed using three parts: (1) biological membranes that serve as protective barriers, while allowing communication ...
Ding, Yunfeng, Tan, Cheemeng, Wu, Fan
core   +2 more sources

Developing synthetic biology for industrial biotechnology applications

open access: yesBiochemical Society Transactions, 2020
Since the beginning of the 21st Century, synthetic biology has established itself as an effective technological approach to design and engineer biological systems.
L. Clarke, R. Kitney
semanticscholar   +1 more source

Analog synthetic biology [PDF]

open access: yesPhilosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 2014
We analyse the pros and cons of analog versus digital computation in living cells. Our analysis is based on fundamental laws of noise in gene and protein expression, which set limits on the energy, time, space, molecular count and part-count resources needed to compute at a given level of precision.
openaire   +2 more sources

Social context prevents heat hormetic effects against mutagens during fish development

open access: yesFEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere   +5 more
wiley   +1 more source

Encryption and steganography of synthetic gene circuits

open access: yesNature Communications, 2018
Artificial gene circuits represent intellectual property that under some circumstances may need to be obfuscated to prevent discovery by third parties. Here the authors use encryption by overlapping recombinase sites and steganography by the introduction
Oliver Purcell   +3 more
doaj   +1 more source

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

open access: yesFEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke   +2 more
wiley   +1 more source

Genome-scale CRISPRi screen identifies pcnB repression conferring improved physiology for overproduction of free fatty acids in Escherichia coli

open access: yesNature Communications
Microbial physiology plays a pivotal role in construction of superior microbial cell factories for efficient biosynthesis of desired products. Here we identify that pcnB repression confers improved physiology for overproduction of free fatty acids (FFAs)
Lixia Fang   +8 more
doaj   +1 more source

Molecular Imaging in Synthetic Biology, and Synthetic Biology in Molecular Imaging [PDF]

open access: yes, 2017
Biomedical synthetic biology is an emerging field in which cells are engineered at the genetic level to carry out novel functions with relevance to biomedical and industrial applications.
Gilad, Assaf A., Shapiro, Mikhail G.
core   +1 more source

The synthetic biology future [PDF]

open access: yesBioengineered, 2014
Herein, I track the evolution of synthetic biology from its earliest incarnations more than 50 years ago, through the DIYbio revolution, to the next 50 years.
openaire   +3 more sources

Ecological Firewalls for Synthetic Biology

open access: yesiScience, 2022
While rapidly becoming a main thread in the development of new therapies, the rise of synthetic biology is also tied to concerns about the potential impact on ecosystems. That is particularly relevant in the of deployment in natural habitats, including the human microbiome. These concerns have boosted the analysis of diverse strategies of containment,
Blai Vidiella, Ricard Sole
openaire   +4 more sources

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