Results 121 to 130 of about 1,044,094 (254)
CD36‐mediated lipid rewiring in the metabolic adaptation of tumour ecosystems
The FEBS Journal, EarlyView.Nutrient deprivation drives a lipid‐centric shift in tumour metabolic symbiosis and signalling network. CD36 functions as a bidirectional bridge, transferring fatty acids from stromal donors (adipocytes, CAFs) to the ecosystem tumour‐ and microenvironment‐dependently.
Anna Sebestyén +11 more
wiley +1 more source
, 2017 Natural cannabinoids and their synthetic substitutes are the most widely used recreational drugs. Numerous clinical cases describe acute toxic symptoms and neurological consequences following inhalation of the mixture of synthetic cannabinoids known as ...
Kosuke Aritake +6 more
core +1 more source
The FEBS Journal, EarlyView.Distinct GPCR phosphorylation barcodes and arrestin conformational states direct arrestin‐mediated signaling and trafficking. The graphical abstract depicts the structural diversity of GPCR–arrestin complexes by overlaying representative core‐engaged and tail‐engaged conformations.
Varsha Gupta +1 more
wiley +1 more source
The development and therapeutic potential of classical and next-generation cannabinoid ligands
Pharmacological ResearchThe endogenous cannabinoid system (ECS) is a complex network that plays a crucial role in various physiological processes, and its modulation through cannabinoid ligands has garnered significant interest in pharmacological research. Cannabinoid receptors,
Verónica Muñoz-Canales +4 more
doaj +1 more source
Novel targets in headache: A narrative review
Headache: The Journal of Head and Face Pain, EarlyView.Abstract Objectives/Background This narrative review summarizes novel applications for the use of calcitonin gene‐related peptide (CGRP)‐targeted therapies that go beyond migraine, the latest updates with respect to targeting pituitary adenylate cyclase‐activating peptide (PACAP) as therapeutic in migraine, as well as exploring other more recently ...
Adriana Della Pietra +5 more
wiley +1 more source
A Spicy Kind of High: A Profile of Synthetic Cannabinoid Users
, 2013 Aims: Over the last 6 years, numerous products have been made available and marketed as “legal highs.” Many of these products contain compounds similar to those within cannabis and function to create a high comparable to that of smoking marijuana. Though
Stogner, John, Miller, Bryan
core +1 more source
The Howard Journal of Crime and Justice, EarlyView.ABSTRACT This article presents an analysis of surveys conducted by HM Inspectorate of Prisons for England and Wales of 87,449 adult male prisoners between the years 2000 and 2020. It describes the survey methodology and focuses on the 13,025 people who reported feeling unsafe.
Nicholas Hardwick +2 more
wiley +1 more source
, 2012 Type 1 cannabinoid receptor (CB1) levels decline in the striatum of animal models of Huntington’s disease (HD) and in the brains of human patients suffering from HD prior to other pathogenic changes.
Laprairie, Robert
core
Systemic, Lifestyle and Environmental Modifying Factors in the Pathogenesis of Periodontitis
Journal of Periodontal Research, EarlyView.A variety of impacting factors in the pathogenesis of periodontitis exist, including systemic, lifestyle, and environmental factors. This review highlights the manifold mechanistic aspects of the link between the pathogenesis of periodontitis, addressing these numerous factors to supplement the long‐standing knowledge of the progression of the disease.
Sabine Elisabeth Groeger +5 more
wiley +1 more source
The Role of Oxidative Stress in Periodontitis
Journal of Periodontal Research, EarlyView.Oxidative stress is involved in multiple chemical reactions that take place in different intracellular organelles: mitochondria, rough endoplasmic reticulum, peroxisomes, autophagy, and aging, and can be influenced by exogenous factors: nutrition, physical activity, psychological status, environmental conditions, microbiome, and drugs.
Pedro Bullon +3 more
wiley +1 more source