Results 151 to 160 of about 1,044,094 (254)

Covalent fluorescent probes for 2‐arachidonoylglycerol metabolic pathways

British Journal of Pharmacology, Volume 183, Issue 22, Page 6656-6662, November 2026.
Abstract Covalent fluorescent probes have emerged as versatile chemical tools to visualise active enzymes in complex biological systems. When tailored for specific applications, ranging from activity‐based protein profiling for drug development to high spatiotemporal resolution imaging of enzymatic activities, these probes provide unique insights into ...
Nick D. F. Puijmbroeck, Mario van der Stelt   +1 more
wiley   +1 more source

Cytotoxic Effects of the Synthetic Cannabinoid, 5F-MDMB-PICA on Human Glioblastoma U87-MG Cells. [PDF]

Int J Med Sci
Alanazi MM, Alasmari F, Algahtani MM, Alhamed AS, Alhosaini KA, Almutairi MM, Alqahtani F, Alanazi WA, Alharbi FN, Alsanie R, Alshehri M, Sari Y.   +11 more
europepmc   +1 more source

Diagnosis and Management of Nitazene Dependence in Sydney, Australia: A Case Series

Drug and Alcohol Review, Volume 45, Issue 7, November 2026.
ABSTRACT Introduction Nitazenes are synthetic opioids with potent μ‐receptor activity. There are increasing reports of nitazene overdoses worldwide. We report on a case series of protonitazene and metonitazene dependence responding to high dose medication for the treatment of opioid dependence in both inpatient and outpatient settings.
Daniel Dutkiewicz, Hester Wilson, Peter Chisholm, Thanjira Jiranantakan, Christine Harvey, Kaniz Fatema, Mark Hardy   +6 more
wiley   +1 more source

The role of the kynurenine pathway in conditioned place aversion induced by synthetic cannabinoid CP-55940. [PDF]

Behav Brain Funct
Cong J, Zhang H, Li N, Yang J, Liu M, Ma Q, Zhang C, Yan G.   +7 more
europepmc   +1 more source

A Comparative Analysis of Deaths Due to Drug‐Related Causes Between Rural and Urban Areas in the United Kingdom, 1997–2026

Drug and Alcohol Review, Volume 45, Issue 7, November 2026.
ABSTRACT Introduction Multiple jurisdictions report disproportionately elevated rates of drug‐related harm in urban settings, alongside unique treatment needs in rural populations. We examined differences in case characteristics, circumstances of death and implicated drugs among individuals dying from drug‐related causes, stratified by rural or urban ...
Emmert Roberts, Jürgen Rehm, Caroline Copeland   +2 more
wiley   +1 more source

Stepwise Conformational Restriction of Acylhydrazone-Based Molecules for High Signal-to-Noise Fluorescent Recognition of Synthetic Cannabinoid FUB-INACA. [PDF]

Angew Chem Int Ed Engl
Zhang Y, Cheng X, Zhao C, Song C, Li J, Zhu R, Ning J, Dou X, Cai Z.   +8 more
europepmc   +1 more source

Cargo Stability of Extracellular Vesicles Derived From Non‐Diseased Sources: Effects of Storage and Handling Conditions

Journal of Cellular and Molecular Medicine, Volume 30, Issue 21, November 2026.
ABSTRACT Extracellular vesicles (EVs) are nanoscale, membrane‐enclosed particles that transfer proteins, nucleic acids, lipids, and other bioactive molecules between cells. Their cargo‐bearing capacity supports applications in drug delivery, regenerative medicine, and biomarker development, but ex vivo handling can alter vesicle recovery and cargo ...
Khadijeh Abbasi, Mina Mohammadinasr, Roza Motavalli, Narges Arianfar, Attabak Toofani‐Milani, Moein Shirzad, Vahid Hosseini, Masoud Darabi   +7 more
wiley   +1 more source

Trichomes in Plant Defence, Development and Metabolic Integration Under Environmental Stress

Plant, Cell &Environment, Volume 49, Issue 11, Page 8437-8453, November 2026.
ABSTRACT Among various plant defence strategies, trichomes are tiny hair‐like structures on the epidermis that aid in defence, environmental adaptation and the production of valuable secondary metabolites. This review features trichomes as frontline guards for plant survival, integrating their structural, physiological and metabolic roles in ...
Debdatta Chatterjee, Madhabi Das, Sanjib Patra, Srijib Chatterjee, Amit Roy, Arunava Mandal   +5 more
wiley   +1 more source

The Synthetic Cannabinoid AKB-48 Induces Cell Death in Murine Cerebellum Through Different Signaling Pathways. [PDF]

Int J Mol Sci
De Luca F, Corli G, Bassi M, Bilel S, Merli D, Lonati D, Schicchi A, Rossi P, Bottone MG, Locatelli CA, Marti M, Roda E.   +11 more
europepmc   +1 more source

The Use of Cannabidiol in Cutaneous Wound Healing: A Systematic Review

The FASEB Journal, Volume 40, Issue 20, 31 October 2026.
Proposed mechanisms by which cannabidiol (CBD) promotes cutaneous wound healing. CBD modulates inflammatory and oxidative pathways, enhances fibroblast migration and proliferation, stimulates collagen deposition and extracellular matrix remodeling, and promotes angiogenesis, collectively contributing to improved tissue repair. ABSTRACT Cutaneous wounds
João Henrique Ferreira França, Renale Beserra de Melo Freitas, Geovanne Lucas Rodrigues Rosendo, Mariana Pereira Carvalho, Glicia Maria de Oliveira, Júlio César Claudino dos Santos, Fernanda das Chagas Angelo Mendes Tenorio, Jaiurte Gomes Martins da Silva   +7 more
wiley   +1 more source