Results 111 to 120 of about 11,438 (231)

Oligonucleotides Post‐Synthetic Modifications: An Overview of Clickable Nucleoside Phosphoramidites Suitable for Solid‐Phase Synthesis

ChemBioChem, Volume 27, Issue 13, 14 July 2026.
Clickable nucleoside phosphoramidites can be incorporated into oligonucleotides via solid‐phase synthesis (SPOS), enabling rapid and site‐specific post‐functionalization using bioorthogonal reactions. This review highlights their design, synthetic accessibility, and SPOS incorporation requirements, along with the kinetics and efficiency of post ...
Sébastien Depienne, Alexandra Bristiel, Dominique Urban, Dominique Guianvarc’h   +3 more
wiley   +1 more source

Rapid LC-QTOF-MS screening method for semi-synthetic cannabinoids in whole blood. [PDF]

J Anal Toxicol
Schirmer W, Walton SE, Weinmann W, Schürch S, Logan BK, Krotulski AJ.   +5 more
europepmc   +1 more source

Might modulation of the endocannabinoid system provide a potential dual therapeutic strategy for osteoporosis and depression?

General Psychiatry, Volume 39, Issue 4, August 2026.
Peng Wei, Pianpian Zhao, Zenghui Gu, Mengyuan Yang, David Karasik, Ching‐Lung Cheung, Houfeng Zheng   +6 more
wiley   +1 more source

Intravenous paracetamol does not have significant opioid‐sparing effects when used as part of a multimodal analgesic protocol in dogs undergoing elective orthopaedic surgery

Veterinary Record, Volume 199, Issue 1, Page e13-e20, 4/11 July 2026.
Abstract Background Data evaluating paracetamol combined with NSAIDs in dogs are scarce. Results of clinical studies in dogs investigating intravenous paracetamol vary. Methods Dogs were randomised to either receive 10 mg/kg paracetamol intravenously after induction of anaesthesia and every 8 hours during hospitalisation (test) or not (control).
Robin Stallard, Julia Deutsch, Joanna Murrell   +2 more
wiley   +1 more source

Beyond the Outburst: Charting a New Frontier for Understanding and Treating Irritability in Autistic Adults

Autism Research, Volume 19, Issue 7, July 2026.
ABSTRACT Irritability is a prevalent and impairing feature associated with autism, yet remains poorly understood, particularly in adults. Drawing heavily on insights translated from pediatric and transdiagnostic literatures, we propose that irritability in autistic individuals often reflects a psychophysiological stress or threat response, rooted in a ...
Hsiang‐Yuan Lin, Arthur N. Westover, Amy S. F. Lutz, Manish K. Jha   +3 more
wiley   +1 more source

Synthetic cannabinoids in human post-mortem samples - ADB-BUTINACA and metabolites in three fatalities. [PDF]

Front Toxicol
Zschiesche A, Köpfler S, Wunder C, Keiler AM, Görg J, Walz CP, Fliss B, Germerott T, Auwärter V, Huppertz LM.   +9 more
europepmc   +1 more source

Multi‐Trait Genetic Insights Into Schizophrenia Across Ancestries: Genome‐Wide Association Meta‐Analyses, Machine Learning, and Drug Repurposing Study

Brain and Behavior, Volume 16, Issue 7, July 2026.
ABSTRACT Background Schizophrenia is a psychiatric disorder characterized by a wide range of symptoms and a complex interplay between genetic and environmental factors. Despite advances in genomics, the genetic underpinnings of SC and its relationship with drug use remain poorly understood.
Ping Yan, Haili Wang, Ye Shu, Rui Xie, Ainiwaner Reyidan, Songnian Fu   +5 more
wiley   +1 more source

Passive Oscillatory Body Motion Attenuates Pain‐Related Behaviors and Increases β‐Endorphin Immunoreactivity in a Murine Fracture Model: A Preliminary Study

Brain and Behavior, Volume 16, Issue 7, July 2026.
ABSTRACT Objective This preliminary study aimed to investigate whether passive oscillatory body motion (PBM), a mechanical stimulus that reproduces vertical accelerations comparable to those generated during treadmill running, could activate the β‐endorphin (β‐END)–related hypothalamus–periaqueductal gray (PAG) pathway and alleviate fracture‐induced ...
Ryoma Kato, Kazuhiro Hayashi, Yuri Okada, Rina Okura, Fuyu Niida, Jun Miyata, Naoyoshi Sakitani, Yasuhiro Sawada, Akira Ito   +8 more
wiley   +1 more source

Data Hidden in Sewage: Advanced Methods for Identification and Quantification of Synthetic Cannabinoids in Urban Wastewater. [PDF]

Molecules
Kurzeja W, Kuczer M, Matysiak J, Klupczyńska-Gabryszak A.   +3 more
europepmc   +1 more source

Assessment of the Acute Toxicity and Anxiolytic‐Like Effect of α‐Humulene in Adult Zebrafish (Danio rerio)

Chemistry &Biodiversity, Volume 23, Issue 7, July 2026.
The monocyclic sesquiterpene α‐humulene elicited a significant anxiolytic‐like behavior in adult zebrafish and no observable acute toxicity. Pharmacological dissection suggested that this effect is independent of the benzodiazepine (BZD) binding site on the gamma‐aminobutyric acid (GABA) type A receptor (GABAAR), but it depends on the serotonin type 3 ...
Alex de Souza Borges, Italo Moura Barbosa, Jéssica Bezerra Maciel, Aluísio Marques da Fonseca, Jesyka Macedo Guedes, Jane Eire Silva Alencar de Menezes, Gyllyandeson de Araujo Delmondes, Marta Regina Kerntopf, Hélcio Silva dos Santos, Alexandre Magno Rodrigues Teixeira   +9 more
wiley   +1 more source