Results 171 to 180 of about 1,032,308 (279)

UVA and UVB Photolysis of Natural and Synthetic Cannabinoids Studied by Online Mass Spectrometry. [PDF]

Molecules
Shaikh ASA, Uleanya KO, Selwe KP, Dessent CEH.   +3 more
europepmc   +1 more source

Discrepancy in Reported and Observed Monoacylglycerol Lipase Inhibition of Aryl Formyl Piperidine Containing Potent and Highly Selective Monoacylglycerol Lipase Inhibitor

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
A reported potent and selective reversible MAGL inhibitor fails to reproduce its claimed potency in two established in vitro assays, even when the previously reported substrate is used, while eight related analogs are likewise inactive. The findings highlight substantial assay‐dependent behavior and the need for careful validation before such compounds
Juha R. Savinainen, Praveen Kumar Singh, Jari Yli‐Kauhaluoma, Jayendra Z. Patel   +3 more
wiley   +1 more source

Analytical method development and validation of a serum LC-MS/MS assay for 2 emerging synthetic cannabinoids: 5F-MDMB-PICA and MDMB-4en-PINACA. [PDF]

Medicine (Baltimore)
Akbaba M, Isir AB, İbili S, Yiğitsoy CE.   +3 more
europepmc   +1 more source

Reorganization of Innate Immune Cell Lipid Profiles by Bioinspired Meroterpenoids to Limit Inflammation

Advanced Science, Volume 13, Issue 59, 23 October 2026.
Resolution pharmacology is an emerging strategy to tackle inflammatory pathologies. Bioinspired meroterpenoids induce a lipid mediator class switch toward inflammation resolution in vitro and in vivo by targeting key nodes in lipid mediator biosynthesis and neutral lipid dynamics.
Lorenz Waltl, David Holubek, Klaus Speck, Raphael Wildermuth, Franz‐Lucas Haut, Stephan Permann, Immanuel Plangger, Christian Steinborn, Zhigang Rao, Danilo D'Avino, Ida Cerqua, Julia Stadler, Fiorentina Roviezzo, Peter Schlenke, Anita Siller, Harald Schennach, Solveigh C. Koeberle, Eva‐Maria Pferschy‐Wenzig, Antonietta Rossi, Thomas Magauer, Andreas Koeberle   +20 more
wiley   +1 more source

The right temperature at the right time: A framework for understanding thermoregulatory pathophysiology in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract The neuromodulatory subcortical system (NSS) includes thermoregulatory neurons that maintain core body temperature (Tb) and brain temperature within a narrow, diurnally varying range. Cellular pathways in NSS neurons implicated in Alzheimer's disease (AD) may be vulnerable to Tb rhythm disturbance because of their sensitivity to temperature ...
Esther Blessing
wiley   +1 more source

Data Hidden in Sewage: Advanced Methods for Identification and Quantification of Synthetic Cannabinoids in Urban Wastewater. [PDF]

Molecules
Kurzeja W, Kuczer M, Matysiak J, Klupczyńska-Gabryszak A.   +3 more
europepmc   +1 more source

Efficacy and safety of cannabinoids in the treatment of spasticity in multiple sclerosis: A systematic review of randomized clinical trials

British Journal of Clinical Pharmacology, Volume 92, Issue 10, Page 3288-3300, October 2026.
Aims This work aimed to evaluate the efficacy and safety of cannabinoids for the treatment of MS‐related spasticity. Methods Systematic searches were conducted in PubMed, EMBASE, and LILACS on 2 December 2025. Randomized controlled trials evaluating natural or synthetic cannabinoids for MS‐related spasticity were included.
Letícia Hamm‐Buiar, Daniela Gorski, Marcela Harumi Kagueiama, Astrid Wiens   +3 more
wiley   +1 more source

The utility of a new point-of-care test for synthetic cannabinoids: a mixed-methods study in people who use synthetic cannabinoids and stakeholders. [PDF]

Harm Reduct J
Skumlien M, Craft S, Russell L, Toshniwal N, Pudney C, Freeman TP, Scott J.   +6 more
europepmc   +1 more source

An Integrated Transient Expression and UPLC‐PDA Approach for Functional Genomics and Metabolic Analysis of Cannabis sativa

Biotechnology Journal, Volume 21, Issue 10, October 2026.
Graphical Abstract and Lay Summary Cannabis research is limited by a lack of efficient tools for studying gene function and metabolism. We developed two rapid, high‐efficiency methods for transient gene expression in high‐THC Cannabis and a simple, cost‐effective method to measure cannabinoids and cannflavins.
Sarah Pullano, Aida Shahabi, Parmis Shariat Torbaghani, Ivan Monsalvo, Madison Sandler, Adam Sumner, Alex Harris, David Haak, Bastiaan Bargmann, Nik Kovinich   +9 more
wiley   +1 more source

Cannabinoid CB1 Receptor Regulates Spinal Dorsal Horn Synaptic Plasticity in a Mouse Model of Neuropathic Pain through the CB1R/SREBP1/NAMPT/SIRT1 Metabolic Regulatory Framework

Brain and Behavior, Volume 16, Issue 10, October 2026.
Abstract Background Neuropathic pain is sustained by maladaptive synaptic plasticity in the spinal dorsal horn. Increasing evidence suggests that metabolic regulation is closely linked to synaptic function, as lipid metabolism, membrane microdomain organization, NAD+‐dependent signaling, and cellular stress‐response pathways can influence receptor ...
Lu Liu, Chenglong Wu, Hui Xia, Jie Cheng, Liang Zhong, Jiang Wu   +5 more
wiley   +1 more source