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In vitro activation of the CB<sub>1</sub> receptor by the semi-synthetic cannabinoids hexahydrocannabinol (HHC), hexahydrocannabinol acetate (HHC-O) and hexahydrocannabiphorol (HHC-P). [PDF]
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2023
New synthetic cannabinoid agonists have been synthesized during the last decades and promoted for their psychoactive effects, mimicking those of delta-9-tetrahydrocannabinol. These newest cannabimimetic drugs show binding affinities for the cannabinoid CB1 and/or the CB2 receptors.
Fattore, Liana, Marti, Matteo
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New synthetic cannabinoid agonists have been synthesized during the last decades and promoted for their psychoactive effects, mimicking those of delta-9-tetrahydrocannabinol. These newest cannabimimetic drugs show binding affinities for the cannabinoid CB1 and/or the CB2 receptors.
Fattore, Liana, Marti, Matteo
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The American Journal of the Medical Sciences, 2015
Synthetic cannabinoids (SCBs), also known under the brand names of "Spice," "K2," "herbal incense," "Cloud 9," "Mojo" and many others, are becoming a large public health concern due not only to their increasing use but also to their unpredictable toxicity and abuse potential.
Brooke, Mills +2 more
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Synthetic cannabinoids (SCBs), also known under the brand names of "Spice," "K2," "herbal incense," "Cloud 9," "Mojo" and many others, are becoming a large public health concern due not only to their increasing use but also to their unpredictable toxicity and abuse potential.
Brooke, Mills +2 more
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Focus on cannabinoids and synthetic cannabinoids
Clinical Pharmacology & Therapeutics, 2016The recent emergence of a multitude of synthetic cannabinoids (SCs) has generated a wealth of new information, suggesting the usefulness of state‐of‐the‐art on lato sensu cannabinoids. By modulating a plurality of neurotransmission pathways, the endocannabinoid system is involved in many physiological processes that are increasingly explored.
R, Le Boisselier +3 more
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Regulation of synthetic cannabinoids
The Lancet, 2009www.thelancet.com Vol 374 November 7, 2009 1595 5 Fuccio L, Zagari RM, Minardi ME, et al. Systematic review: Helicobacter pylori eradication for the prevention of gastric cancer. Aliment Pharmacol Ther 2007; 25: 133–41. As Greta McLachlan reports, the UK Advisory Council for the Misuse of Drugs (ACMD) and the European Monitoring Centre for Drugs and ...
C Heather, Ashton, P Brian, Moore
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Synthetic cannabinoids revealing adrenoleukodystrophy
Journal of Clinical Neuroscience, 2016We report a 41-year-old man who presented with a first generalized tonic-clonic seizure after recent consumption of a synthetic cannabinoid. MRI showed extensive bilateral, mainly frontal, white matter lesions. Blood analysis for very long chain fatty acids was compatible with adrenoleukodystrophy, and a missense mutation in the ABCD1 gene confirmed ...
Avi, Fellner +2 more
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Nonpsychotropic Synthetic Cannabinoids
Current Pharmaceutical Design, 2000Unlike natural cannabinoids which belong to the 6aR - trans series, the synthetic dexanabinol (HU-211), a 6aS-trans enantiomer, does not have affinity toward cannabinoid receptors and is devoid of cannabimimetic activity. On the other hand, dexanabinol demonstrated significant neuroprotective properties which prompted its development as a therapeutic ...
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The Synthetic Cannabinoids Phenomenon
Current Pharmaceutical Design, 2017« Spice » is generally used to describe the diverse types of herbal blends that encompass synthetic cannabinoids on the market. The emergence of smokable herbal products containing synthetic cannabinoids, which mimic the effects of cannabis, appears to become increasingly popular, in the new psychoactive substances landscape.
Karila, Laurent +4 more
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