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Synthetic cells in tissue engineering
Current Opinion in BiotechnologyTissue functions rely on complex structural, biochemical, and biomechanical cues that guide cellular behavior and organization. Synthetic cells, a promising new class of biomaterials, hold significant potential for mimicking these tissue properties using simplified, nonliving building blocks. Advanced synthetic cell models have already shown utility in
Anna Burgstaller +2 more
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Towards Synthetic Cells with Self-Producing Energy. [PDF]
ChempluschemAutonomous generation of energy, specifically adenosine triphosphate (ATP), is critical for sustaining the engineered functionalities of synthetic cells constructed from the bottom-up. In this mini-review, we categorize studies on ATP-producing synthetic
Hwang SW, Kim M, Liu AP.
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Engineering DNA-based cytoskeletons for synthetic cells. [PDF]
Interface Focus, 2023 The development and bottom-up assembly of synthetic cells with a functional cytoskeleton sets a major milestone to understand cell mechanics and to develop man-made machines on the nano- and microscale.
Jahnke K, Göpfrich K.
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Synthetic cells for phage therapy: a perspective [PDF]
Frontiers in Cellular and Infection MicrobiologyA synthetic cell is a membrane-bound vesicle that encapsulates cell-free transcription/translation (TXTL) systems. It represents a transformative platform for advancing bacteriophage therapy.
Vishwesh Kulkarni +4 more
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Designer peptide-DNA cytoskeletons regulate the function of synthetic cells. [PDF]
Nat ChemThe bottom-up engineering of artificial cells requires a reconfigurable cytoskeleton that can organize at distinct locations and dynamically modulate its structural and mechanical properties. Here, inspired by the vast array of actin-binding proteins and
Daly ML +5 more
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Magnetic Modulation of Biochemical Synthesis in Synthetic Cells. [PDF]
J Am Chem SocSynthetic cells can be constructed from diverse molecular components, without the design constraints associated with modifying 'living' biological systems.
Zhu KK +5 more
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Synthetic cells by the numbers [PDF]
iScienceSummary: Can we build a living cell from non-living molecular components? This foundational question drives the field of synthetic cell engineering, having already reconstituted key cellular processes within synthetic environments, and now advancing ...
Chana G. Sokolik +4 more
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Synthetic cells in biomedical applications
WIREs Nanomedicine and Nanobiotechnology, 2021 AbstractSynthetic cells are engineered vesicles that can mimic one or more salient features of life. These features include directed localization, sense‐and‐respond behavior, gene expression, metabolism, and high stability. In nanomedicine, many of these features are desirable capabilities of drug delivery vehicles but are difficult to engineer.
Wakana Sato +3 more
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Elastin-like polypeptide coacervates as reversibly triggerable compartments for synthetic cells. [PDF]
Commun ChemCompartmentalization is a vital aspect of living cells to orchestrate intracellular processes. In a similar vein, constructing dynamic and responsive sub-compartments is key to synthetic cell engineering.
Chen C +6 more
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Genetically programmed synthetic cells for thermo-responsive protein synthesis and cargo release. [PDF]
Nat Chem BiolSynthetic cells containing genetic programs and protein expression machinery are increasingly recognized as powerful counterparts to engineered living cells in the context of biotechnology, therapeutics and cellular modelling.
Monck C, Elani Y, Ceroni F.
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