Results 11 to 20 of about 2,867,164 (299)
Translating DNA into synthetic molecules.
PLoS Biology, 2004 The unique ability of nucleic acids to replicate has recently been combined with the power of combinatorial chemistry, providing a new approach to the science of drug ...
David R Liu
doaj +4 more sources
Evolution of repetitive DNA in angiosperms: examples from Nicotiana allopolyploids [PDF]
, 2012 PhDAllopolyploidy, interspecific hybridisation coupled with genome multiplication, is a prevailing force in the evolution of angiosperms. This thesis examines the consequences of allopolyploidy at the genomic level.
Renny-Byfield, Simon
core +4 more sources
An allosteric synthetic DNA [PDF]
Nucleic Acids Research, 1999 Allosteric DNA oligonucleotides are potentially useful diagnostic reagents. Here we develop a model system for the study of allosteric interactions in DNAs. A DNA that binds either Cibacron blue or cholic acid was isolated and partially characterized. Isolation was performed using a multi-stage SELEX.
L, Wu, J F, Curran
openaire +2 more sources
Synthetic DNA Synthesis and Assembly: Putting the Synthetic in Synthetic Biology [PDF]
Cold Spring Harbor Perspectives in Biology, 2017 The chemical synthesis of DNA oligonucleotides and their assembly into synthons, genes, circuits, and even entire genomes by gene synthesis methods has become an enabling technology for modern molecular biology and enables the design, build, test, learn, and repeat cycle underpinning innovations in synthetic biology.
Randall A, Hughes, Andrew D, Ellington
openaire +2 more sources
Digital Preservation with Synthetic DNA
, 2022 The growing adoption of AI and data analytics in various sectors has resulted in digital preservation emerging as a cross-sectoral problem that affects everyone from data-driven enterprises to memory institutions alike. As all contemporary storage media suffer from fundamental density and durability limitations, researchers have started investigating ...
Marinelli, Eugenio +6 more
openaire +3 more sources
Synthetic DNA and RNA Programming. [PDF]
Genes (Basel), 2019 Synthetic biology is a broad and emerging discipline that capitalizes on recent advances in molecular biology, genetics, protein and RNA engineering as well as omics technologies. Together these technologies have transformed our ability to reveal the biology of the cell and the molecular basis of disease.
O'Donoghue P, Heinemann IU.
europepmc +5 more sources
Thermo-programmed synthetic DNA-based receptors [PDF]
, 2022 Here we present a generalizable and versatile strategy to rationally design synthetic DNA ligand-binding devices that can be programmed to load and release a ligand over a specific temperature range.
Davide, Mariottini +2 more
core +2 more sources
The Electromechanics of DNA in a Synthetic Nanopore [PDF]
Biophysical Journal, 2006 We have explored the electromechanical properties of DNA on a nanometer-length scale using an electric field to force single molecules through synthetic nanopores in ultrathin silicon nitride membranes. At low electric fields, E < 200 mV/10 nm, we observed that single-stranded DNA can permeate pores with a diameter >/=1.0 nm, whereas double-stranded ...
Heng, J.B. +7 more
openaire +2 more sources
The ethics of synthetic DNA [PDF]
Journal of Medical EthicsIn this paper, we discuss the ethical concerns that may arise from the synthesis of human DNA. To date, only small stretches of DNA have been constructed, but the prospect of generating human genomes is becoming feasible. At the same time, the significance of genes for identity, health and reproduction is coming under increased scrutiny. We examine the
Adrian Villalba +3 more
openaire +2 more sources
Synthetic biology—putting engineering into biology [PDF]
, 2006 Synthetic biology is interpreted as the engineering-driven building of increasingly complex biological entities for novel applications. Encouraged by progress in the design of artificial gene networks, de novo DNA synthesis and protein engineering, we ...
Panke, Sven +3 more
core +1 more source