Results 41 to 50 of about 2,867,164 (299)
PharmaceuticsBackground/Objectives: Antisense oligonucleotides (ASOs) hold great therapeutic potential due to their precise ability to modulate gene expression, particularly for treating genetic and neurological disorders.
Jieyan He +9 more
doaj +1 more source
Modulating the influenza A virus – target membrane fusion interface with synthetic DNA-lipid receptors [PDF]
, 2021 Influenza A virus (IAV) binds to sialylated glycans on the cell membrane before endocytosis and fusion. Cell surface glycans are highly heterogenous in length and glycosylation density, which leads to variation in the distance and rigidity with which IAV
Elizabeth, Webster +3 more
core +1 more source
Processing DNA Storage through Programmable Assembly in a Droplet‐Based Fluidics System
Advanced Science, 2023 DNA can be used to store digital data, and synthetic short‐sequence DNA pools are developed to store high quantities of digital data. However, synthetic DNA data cannot be actively processed in DNA pools.
Minsang Yu +3 more
doaj +1 more source
Shuffling of DNA Cassettes in a Synthetic Integron [PDF]
, 2013 The complexity of even small gene networks makes them hardly amenable to rational design. Testing random combinations of genetic elements in a directed evolution procedure is thus of interest for many applications including metabolic engineering. Here we describe how the recombination machinery of class 1 integrons can be used to deliver and shuffle ...
Bikard, David, Mazel, Didier
openaire +3 more sources
Beilstein Journal of Organic Chemistry, 2014 Background: Many synthetic biologists seek to increase the degree of autonomy in the assembly of long DNA (L-DNA) constructs from short synthetic DNA fragments, which are today quite inexpensive because of automated solid-phase synthesis.
Kristen K. Merritt +5 more
doaj +1 more source
DNA Photonics – Photoinduced Electron Transfer in Synthetic DNA-Donor–Acceptor Systems
CHIMIA, 2007 Recent experimental and theoretical results have demonstrated that structural dynamics are critical for a comprehensive mechanistic understanding of DNA charge transfer (CT).
Torsten Fiebig, Hans-Achim Wagenknecht
doaj +1 more source
Gene transfer into hepatocytes using asialoglycoprotein receptor mediated endocytosis of DNA complexed with an artificial tetra-antennary galactose ligand [PDF]
, 1992 We have constructed an artificial ligand for the hepatocyte-specific asialoglycoprotein receptor for the purpose of generating a synthetic delivery system for DNA.
Zatloukal, Kurt +9 more
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Synthetic DNA for Cell‐Surface Engineering
Angewandte Chemie, 2021 AbstractThe cell membrane is not only a physical barrier, but also a functional organelle that regulates the communication between a cell and its environment. The ability to functionalize the cell membrane with synthetic molecules or nanostructures would advance cellular functions beyond what evolution has provided.
Peng Shi, Yong Wang
openaire +4 more sources
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source