Results 21 to 30 of about 3,003,336 (196)
DNA-Based Synthetic Growth Factor Surrogates with Fine-Tuned Agonism [PDF]
, 2019 Designing synthetic surrogates of functional proteins is an important, albeit challenging, task in the field of chemistry. A strategy toward the design of synthetic agonists for growth factors or cytokine receptors that elicit a desired signal activity ...
Ryosuke Ueki (7298072) +2 more
core +3 more sources
The ethics of synthetic DNA [PDF]
Journal of Medical EthicsIn this paper, we discuss the ethical concerns that may arise from the synthesis of human DNA. To date, only small stretches of DNA have been constructed, but the prospect of generating human genomes is becoming feasible. At the same time, the significance of genes for identity, health and reproduction is coming under increased scrutiny. We examine the
Adrian Villalba +3 more
openaire +2 more sources
DNA repair and synthetic lethality [PDF]
International Journal of Oral Science, 2011 Tumors often have DNA repair defects, suggesting additional inhibition of other DNA repair pathways in tumors may lead to synthetic lethality. Accumulating data demonstrate that DNA repair-defective tumors, in particular homologous recombination (HR), are highly sensitive to DNA-damaging agents. Thus, HR-defective tumors exhibit potential vulnerability
Guo, Gong-she +5 more
openaire +3 more sources
Modeling structure-function relationships in synthetic DNA sequences using attribute grammars [PDF]
, 2009 Recognizing that certain biological functions can be associated with specific DNA sequences has led various fields of biology to adopt the notion of the genetic part.
Cai, Yizhi; id_orcid +14 more
core +1 more source
Carbon storage and DNA absorption in allophanic soils and paleosols [PDF]
, 2014 Andisols and andic paleosols dominated by the nanocrystalline mineral allophane sequester large amounts of carbon (C), attributable mainly to its chemical bonding with charged hydroxyl groups on the surface of allophane together with its physical ...
Louis A. Schipper +11 more
core +1 more source
DNA-Origami Line-Actants Control Domain Organization and Fission in Synthetic Membranes
Cells can precisely program the shape and lateral organization of their membranes using protein machinery. Aiming to replicate a comparable degree of control, here we introduce DNA-origami line-actants (DOLAs) as synthetic analogues of membrane-sculpting
Roger Rubio-Sánchez (10323984) +3 more
core +8 more sources
Function of synthetic Hox transcription factors "in vivo" and the quantitative study of their molecular interactions with nuclear DNA at the single-molecule level in live cells [PDF]
, 2010 Over a century of research, invested in providing an answer to the fundamental question of how a single diploid cell constructs a whole organism, has placed Drosophila in the fore scene of developmental biology and has allowed us to merge the knowledge ...
Papadopoulos, Dimitrios
core +1 more source
Programmable in vivo selection of arbitrary DNA sequences. [PDF]
PLoS ONE, 2012 The extraordinary fidelity, sensory and regulatory capacity of natural intracellular machinery is generally confined to their endogenous environment. Nevertheless, synthetic bio-molecular components have been engineered to interface with the cellular ...
Tuval Ben Yehezkel +4 more
doaj +1 more source
A DNA Segregation Module for Synthetic Cells
Small, 2022 Abstract The bottom‐up construction of an artificial cell requires the realization of synthetic cell division. Significant progress has been made toward reliable compartment division, yet mechanisms to segregate the DNA‐encoded informational content are still in their infancy.
Mai P. Tran +7 more
openaire +6 more sources
Research progress for the development of anti-tumor drugs based on synthetic lethality
生物医学转化, 2022 Synthetic lethality describes a phenomenon where mutation of any one of two non-lethal genes does not affect cell survival, whereas mutation of both genes significantly compromise cell viability.
Chen Pei +3 more
doaj +1 more source