Synthetic yeast chromosome XI design provides a testbed for the study of extrachromosomal circular DNA dynamics [PDF]
, 2023 We describe construction of the synthetic yeast chromosome XI (synXI) and reveal the effects of redesign at non-coding DNA elements. The 660-kb synthetic yeast genome project (Sc2.0) chromosome was assembled from synthesized DNA fragments before CRISPR ...
Ciurkot, Klaudia +35 more
core +1 more source
Modeling structure-function relationships in synthetic DNA sequences using attribute grammars [PDF]
, 2009 Recognizing that certain biological functions can be associated with specific DNA sequences has led various fields of biology to adopt the notion of the genetic part.
Cai, Yizhi; id_orcid +13 more
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DNA compaction induced by a cationic polymer or surfactant impact gene expression and DNA degradation. [PDF]
PLoS ONE, 2014 There is an increasing interest in achieving gene regulation in biotechnological and biomedical applications by using synthetic DNA-binding agents. Most studies have so far focused on synthetic sequence-specific DNA-binding agents.
Marie-Louise Ainalem +6 more
doaj +1 more source
Protein-Controlled Actuation of Dynamic Nucleic Acid Networks Using Synthetic DNA Translators [PDF]
, 2020 Integrating dynamic DNA nanotechnology with protein-controlled actuation will expand our ability to process molecular information. We have developed a strategy to actuate strand displacement reactions using DNA-binding proteins by engineering synthetic ...
Erica Del, Grosso +5 more
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Programmable in vivo selection of arbitrary DNA sequences. [PDF]
PLoS ONE, 2012 The extraordinary fidelity, sensory and regulatory capacity of natural intracellular machinery is generally confined to their endogenous environment. Nevertheless, synthetic bio-molecular components have been engineered to interface with the cellular ...
Tuval Ben Yehezkel +4 more
doaj +1 more source
DNA-BOT: a low-cost, automated DNA assembly platform for synthetic biology [PDF]
, 2020 Multi-part DNA assembly is the physical starting point for many projects in Synthetic and Molecular Biology. The ability to explore a genetic design space by building extensive libraries of DNA constructs is essential for creating programmed biological ...
Haines, Matthew C +2 more
core +1 more source
Research progress for the development of anti-tumor drugs based on synthetic lethality
生物医学转化, 2022 Synthetic lethality describes a phenomenon where mutation of any one of two non-lethal genes does not affect cell survival, whereas mutation of both genes significantly compromise cell viability.
Chen Pei +3 more
doaj +1 more source
A DNA Segregation Module for Synthetic Cells
Small, 2022 Abstract The bottom‐up construction of an artificial cell requires the realization of synthetic cell division. Significant progress has been made toward reliable compartment division, yet mechanisms to segregate the DNA‐encoded informational content are still in their infancy.
Mai P. Tran +7 more
openaire +6 more sources
Function of synthetic Hox transcription factors "in vivo" and the quantitative study of their molecular interactions with nuclear DNA at the single-molecule level in live cells [PDF]
, 2010 Over a century of research, invested in providing an answer to the fundamental question of how a single diploid cell constructs a whole organism, has placed Drosophila in the fore scene of developmental biology and has allowed us to merge the knowledge ...
Papadopoulos, Dimitrios
core +1 more source
Image storage onto synthetic DNA
Signal Processing: Image Communication, 2021 Abstract Living in the age of data explosion, the research of solutions for efficient long term storage of the infrequently used ”cold” data is becoming of great interest. However, even if existing storage systems suggest efficiency in capacity, they are lacking in durability.
Dimopoulou, Melpomeni +3 more
openaire +2 more sources