Results 131 to 140 of about 1,134,240 (310)

Synthetic Speech Discrimination using Pitch Pattern Statistics Derived from Image Analysis [PDF]

, 2012
In this paper, we extend the work by Ogihara, et al. to discriminate between human and synthetic speech using features based on pitch patterns. As previously demonstrated, significant differences in pitch patterns between human and synthetic speech can ...
Stewart, Bryan, Leon, Phillip L. De, Yamagishi, Junichi   +2 more
core  

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

A novel machine learning framework-based rapid screening of ionizable lipids in LNPs for highly-efficient mRNA expression

Acta Pharmaceutica Sinica B
Ionizable lipids are a pivotal component for lipid nanoparticles (LNPs) to optimize mRNA expression to fulfill the broad demands of various mRNA therapeutics.
Xing Duan, Jiezhou Chen, Shanhui Jiang, Linbo Qing, Xi He, Jun He, Yinjie Lei, Haixing Shi, Tingting Song, Xiangyu Jiao, Guohong Li, Hai Huang, Mengran Guo, Yongjun Gu, Changchun Zhao, Xiaoling Yin, Shengbin Liu, Pingyu Wang, Xiangrong Song   +18 more
doaj   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Reversible Optical Control of Monolayers on Water through Photoswitchable Lipids

, 2011
We have obtained molecular insights into a monolayer of azobenzene-based photoswitchable lipids self-assembled on water, using the surface sensitive technique vibrational sum-frequency generation spectroscopy in combination with surface pressure ...
Kuiper, Johanna, Poolman, Bert,, Kuiper, Johanna M.,, Engberts, Jan B.F.N., Mischa Bonn, Ellen H. G. Backus, Bonn, Mischa, Bert Poolman, Johanna M. Kuiper, Poolman, Bert, Jan B. F. N. Engberts, Engberts, Jan B.F.N.,, Bonn, Mischa,, Backus, Ellen H.G.,, Backus, Ellen H.G.   +14 more
core   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Generating a Jump Distance Based Synthetic Disk Access Pattern [PDF]

, 2006
As part of our on-going research into improving the quality of synthetic, block-level I/O workloads, we have developed an algorithm that generates a synthetic (i.e., random) disk access pattern based on both (1) a given distribution of sectors accessed ...
Kurmas, Dr. Zachary
core