Results 111 to 120 of about 1,368,992 (302)

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Synthesis of diglycerides containing polyunsaturated fatty acids

Тонкие химические технологии, 2012
Synthetic approaches to obtain diglycerides containing polyunsaturated fatty acids at C(2 ) position of glycerol were developed. These compounds can be used to generate antitumor lipids and enzymatically triggered liposomes .
M. S. Tsapleva, N. V. Plyavnik, G. A. Serebrennikova   +2 more
doaj  

Synthesis of oligo(ethyleneglycol) substituted phosphatidylcholines: Secretory PLA2-targeted precursors of NSAID prodrugs [PDF]

, 2010
A series of new phosphatidylcholine analogues with structurally modified sn-2-substituents have been prepared. The synthetic compounds include oligo(ethylene glycol) derivatives with chain-terminal pharmacophores that upon catalytic hydrolysis by ...
Renato Rosseto, Joseph Hajdu
core  

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Endogenous ether lipids differentially promote tumor aggressiveness by regulating the SK3 channel

Journal of Lipid Research
SK3 channels are potassium channels found to promote tumor aggressiveness. We have previously demonstrated that SK3 is regulated by synthetic ether lipids, but the role of endogenous ether lipids is unknown.
Marion Papin, Delphine Fontaine, Caroline Goupille, Sandy Figiel, Isabelle Domingo, Michelle Pinault, Cyrille Guimaraes, Nina Guyon, Pierre François Cartron, Patrick Emond, Antoine Lefevre, Maxime Gueguinou, David Crottès, Paul-Alain Jaffrès, Lobna Ouldamer, Karine Maheo, Gaëlle Fromont, Marie Potier-Cartereau, Philippe Bougnoux, Aurélie Chantôme, Christophe Vandier   +20 more
doaj   +1 more source

Modulating Liposome Surface Charge for Maximized ATP Regeneration in Synthetic Nanovesicles.

In vitro reconstructed minimal respiratory chains are powerful tools to investigate molecular interactions between the different enzyme components and how they are influenced by their environment.
von Ballmoos, Christoph, Rimle, Lukas, Täuber, Stefan Theodore, Biner, Oliver, Schori, Martin, Deutschmann, Sabina, Stanic, Ana-Marija   +6 more
core   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Imidazole Headgroup Phospholipid Shows Asymmetric Distribution in Vesicles and Zinc-Dependent Esterase Activity

Biomolecules
Artificial lipids have become increasingly important in generating novel nanoenzymes and nanoparticles. Imidazole has been well established as a versatile catalyst in synthetic chemistry and through its related amino acid histidine in enzymes.
Gabriela Sachet-Fernandez, James W. Hindley, Oscar Ces, Rüdiger Woscholski   +3 more
doaj   +1 more source

Chemistry and properties of lipids and phospholipids

, 2017
Lipids are referred to as a large and diverse group of naturally occurring compounds. The term “lipid” is restricted to long-chain fatty acids, their derivatives, and compounds that are related structurally and functionally to them [1,2]. They are highly
Guo, Zheng, Pérez, Bianca, Li, Jingbo
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source