Results 101 to 110 of about 273,223 (309)

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Safety and biodistribution of sulfated archaeal glycolipid archaeosomes as vaccine adjuvants

Human Vaccines & Immunotherapeutics, 2018
Archaeosomes are liposomes comprised of ether lipids derived from various archaea. Unlike conventional ester-linked liposomes, archaeosomes exhibit high pH and thermal stability. As adjuvants, archaeosomes can induce robust, long-lasting humoral and cell-
Bassel Akache, Felicity C. Stark, Umar Iqbal, Wangxue Chen, Yimei Jia, Lakshmi Krishnan, Michael J. McCluskie   +6 more
doaj   +1 more source

Effect of charged lipids on the ionization behavior of glutamic acid containing transmembrane helices [PDF]

, 2020
Transmembrane proteins make up critical components of living cells. Protein function can be greatly impacted by the charged state of its respective components, the side chains of amino acid residues.
Nunn, Brooke
core   +2 more sources

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

Studies of Tryptophans in Membrane- Spanning WALP Peptides by Deuterium NMR Spectroscopy [PDF]

, 2000
WALP pep tides of sequence acetyl-Gly-Trp-Trp-(Leu-Ala)-Trp-Trp-Ala-ethanolamine insert into lipid bilayers as membrane-spanning a-helices and modulate the lipid phase behavior as functions of n and the lipid acyl chain length.
Reed, Nichole
core   +2 more sources

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Chemical synthesis of ω- hydroxyderivatives of plant fatty acid substrates.

Тонкие химические технологии, 2006
A common synthetic procedure for the synthesis of (9Z,12Z)-18-hydroxy-9,12- octadecadienoic acid (18-HODE) and (9Z,12Z,15Z)-18-hydroxy-9,12,15- octadecatrienoic acid (18-HOTrE) – analogues of substrates of plant lipids oxygenation was developed.
N. V. Groza, I. V. Ivanov, A. B. Golovanov, G. I. Myagkova   +3 more
doaj  

Lxr-driven enterocyte lipid droplet formation delays transport of ingested lipids[S]

Journal of Lipid Research, 2014
Liver X receptors (Lxrs) are master regulators of cholesterol catabolism, driving the elimination of cholesterol from the periphery to the lumen of the intestine.
Lourdes Cruz-Garcia, Amnon Schlegel
doaj   +1 more source

Molecular recognition on synthetic lipid membranes.

membrane, 1991
We reviewed a sensing system and mechanism of bitter and odorous compound by using a lipid-coated quartz-crystal microbalance. Strength of bitter taste and odorant can be explained by the adsorption amount to a lipid matrix : the stronger bitter or odorous compound absorbs into the lipid membrane with the larger amount.
openaire   +2 more sources

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source