Results 91 to 100 of about 1,368,992 (302)

Roles of polyunsaturated fatty acids, from mediators to membranes

Journal of Lipid Research, 2020
PUFAs, such as AA and DHA, are recognized as important biomolecules, but understanding their precise roles and modes of action remains challenging. PUFAs are precursors for a plethora of signaling lipids, for which knowledge about synthetic pathways and ...
Takeshi Harayama, Takao Shimizu
doaj   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Synthetic Lipids for Drug Delivery Applications

, 2015
Solid lipid nanoparticles (SLNPs) and lipid-drug conjugates (LDCs) are two promising lipid nanoparticle (LNP) based drug delivery systems; this thesis explores new synthetic lipids that may circumvent the limitations of currently available components for
Meanwell, Michael Weiwei
core  

Emerging evidence for the modulation of exocytosis by signalling lipids [PDF]

, 2018
International audienceMembrane fusion is a key event in exocytosis of neurotransmitters and hormones stored in intracellular vesicles. In this process, soluble N‐ethylmaleimide sensitive factor attachment protein receptor (SNARE) proteins are essential ...
Gutiérrez, L.M., José Villanueva, Frederic D. Darios, Davletov, Bazbek, Virginia Garcia‐Martinez, Darios, Frédéric, Gimenez-Molina, Yolanda, Garcia-Martinez, V., Gimenez-Molina, Y., Yolanda Gimenez‐Molina, Bazbek Davletov, García-Martinez, Virginia, Luis M. Gutiérrez, Gutierrez, Luis,, Villanueva, José, Darios, Frédéric,, Darios, F.D., Villanueva, J., Davletov, B., Darios, Frédéric, D, Gutierrez, Luis, M, Gutiérrez, Luis M.   +21 more
core   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Antioxidants, their properties, uses in food products and their legal implications

International Journal of Food Studies, 2013
Oxidation decreases consumer acceptability of food by changing its organoleptic properties, destroying essential nutrients and producing toxic compounds. Antioxidants delay oxidation of lipids in foods as well in human systems.
Indrajit D. Thorat, Dipali D. Jagtap, Debabandya Mohapatra, D. C. Joshi, R. F. Sutar, S. S. Kapdi   +5 more
doaj   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

The Interaction between a Synthetic Amphiphilic Polypeptide and Lipids

Biophysical Journal, 1982
Most spectroscopic studies designed to examine the interactions between phospholipid and protein molecules in biological membranes have involved measurements of the perturbation of the orientational order of lipids due to the presence of proteins (1).
Davis, James H., Hodges, Robert S., Bloom, Myer   +2 more
openaire   +2 more sources

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source