Results 91 to 100 of about 273,223 (309)

Spatial control of Draper receptor signaling initiates apoptotic cell engulfment. [PDF]

, 2017
The engulfment of apoptotic cells is essential for tissue homeostasis and recovering from damage. Engulfment is mediated by receptors that recognize ligands exposed on apoptotic cells such as phosphatidylserine (PS).
Adam P. Williamson, Arandjelovic, Bunnell, Burroughs, Carbone, Cherbas, Choudhuri, Cordoba, Davis, Dawson, DeMond, Edelstein, Elliott, Erlandson, Etchegaray, Fadok, Freeman, Freeman, Freeman, Fujita, Hui, Iram, James, Kaizuka, Kawano, Kuraishi, Kurant, Leventis, Lewis, Lim, Lu, MacDonald, Manaka, Mayer, Morrissey, Murugesan, Nagaosa, Neumann, Okada, Pellicena, Ravichandran, Reddien, Ronald D. Vale, Scheib, Schlam, Schmid, Schneider, Segawa, Stinchcombe, Tung, Yamauchi, Yi, Zhang, Zhou, Ziegenfuss, Ziegenfuss   +55 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Antioxidants, their properties, uses in food products and their legal implications

International Journal of Food Studies, 2013
Oxidation decreases consumer acceptability of food by changing its organoleptic properties, destroying essential nutrients and producing toxic compounds. Antioxidants delay oxidation of lipids in foods as well in human systems.
Indrajit D. Thorat, Dipali D. Jagtap, Debabandya Mohapatra, D. C. Joshi, R. F. Sutar, S. S. Kapdi   +5 more
doaj   +1 more source

Bem1p contributes to secretory pathway polarization through a direct interaction with Exo70p. [PDF]

, 2014
The exocyst serves to tether secretory vesicles to cortical sites specified by polarity determinants, in preparation for fusion with the plasma membrane.
Liu, Dongmei, Novick, Peter
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

On-chip inverted emulsion method for fast giant vesicle production, handling, and analysis

, 2020
Liposomes and giant unilamellar vesicles (GUVs) in particular are excellent compartments for constructing artificial cells. Traditionally, their use requires bench-top vesicle growth, followed by experimentation under a microscope.
Robinson, T., Seemann, T., Yandrapalli, N.   +2 more
core   +1 more source

Droplet Networks, from Lipid Bilayers to Synthetic Tissues [PDF]

, 2019
An aqueous droplet in a solution of lipid in oil acquires a lipid monolayer coat. When two such droplets are brought together, they adhere through the formation of a droplet interface bilayer (DIB) (Fig. 1a). A high contact angle at the interface (Fig. 1a) indicates a strong interaction between the droplets (Thiam et al. 2012).
Booth, M, Restrepo Schild, V, Downs, F, Bayley, J   +3 more
openaire   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

PexRAP inhibits PRDM16-mediated thermogenic gene expression [PDF]

, 2017
How the nuclear receptor PPARγ regulates the development of two functionally distinct types of adipose tissue, brown and white fat, as well as the browning of white fat, remains unclear.
Dean, John M, Feng, Chu, He, Anyuan, Hsu, Fong-Fu, Lodhi, Irfan J, Park, Hongsuk, Semenkovich, Clay F, Song, Haowei, Tan, Min   +8 more
core   +3 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source