Results 71 to 80 of about 1,368,992 (302)

Unveiling the dynamics of synthetic membrane interfaces through ultrafast spectroscopy [PDF]

Synthetic lipids are of significant importance in various fields, including biosensors, drug delivery, synthetic biology, and the study of the transition from non-living matter to life.
Xu, Cong, Ph. D.
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Protocol for building synthetic protocell membranes that sense redox using synthetic phospholipids and natural lipids

STAR Protocols
Summary: Sensing is a critical function of artificial cells; however, this is challenging to realize using bottom-up approaches. Here, we present a protocol for building protocell membranes that sense cues important for redox biochemistry and signaling ...
Liming Wang, Mark J. Dresel, Monique Robinson, Enver Cagri Izgu   +3 more
doaj   +1 more source

Genetically controlled membrane synthesis in liposomes

Nature Communications, 2020
Controlled membrane synthesis in liposomes is a prerequisite for synthetic systems emulating the fundamental properties of living cells. Here authors present that a de novo synthesized metabolic pathway converts precursors into a variety of lipids ...
Duco Blanken, David Foschepoth, Adriana Calaça Serrão, Christophe Danelon   +3 more
doaj   +1 more source

Defining the Diffusion in Model Membranes Using Line Fluorescence Recovery after Photobleaching

Membranes, 2020
In this study, we explore the use of line FRAP to detect diffusion in synthetic lipid membranes. The study of the dynamics of these membrane lipids can, however, be challenging.
Jakob L. Kure, Camilla B. Andersen, Thomas E. Rasmussen, B. Christoffer Lagerholm, Eva C. Arnspang   +4 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Membrane lipids and their degradation compounds control GM2 catabolism at intralysosomal luminal vesicles

Journal of Lipid Research, 2019
The catabolism of ganglioside GM2 is dependent on three gene products. Mutations in any of these genes result in a different type of GM2 gangliosidosis (Tay-Sachs disease, Sandhoff disease, and the B1 and AB variants of GM2 gangliosidosis), with GM2 as ...
Susi Anheuser, Bernadette Breiden, Konrad Sandhoff   +2 more
doaj   +1 more source

Association between Lipids, Apolipoproteins and Telomere Length: A Mendelian Randomization Study

, 2023
(1) Background: The relationship between lipids, apolipoproteins, and telomere length (TL) has been explored in previous studies; however, the causal relationship between the two remains unclear.
Jiamin Xu, Feng Zhu, Gehua Zhu, Guanghua Guo   +3 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Designer lipids for drug delivery: From heads to tails [PDF]

, 2014
For four decades, liposomes composed of both naturally occurring and synthetic lipids have been investigated as delivery vehicles for low molecular weight and macromolecular drugs.
Vincent J. Venditto, Venditto, Vincent J, Aditya G. Kohli, Colin L. Walsh, Walsh, Colin L, Francis C. Szoka, Paul H. Kierstead, Kierstead, Paul H, Szoka, Francis C, Kohli, Aditya G   +9 more
core   +1 more source