Results 51 to 60 of about 136,463 (299)

Linearly concatenated cyclobutane (ladderane) lipids form a dense bacterial membrane

, 2002
Lipid membranes are essential to the functioning of cells, enabling the existence of concentration gradients of ions and metabolites. Microbial membrane lipids can contain three-, five-, six- and even seven-membered aliphatic rings, but four-membered ...
Hopmans, E.C., Rijpstra, W.I.C., Niftrik, L.A., Geenevasen, J.A.J., Sinnighe, J.S., Duin, A.C.T. van, Strous, M., Sinninghe Damsté, J.S., Jetten, M.S.M., Strous, G.J.A.M., van Duin, A.C.T.   +10 more
core   +1 more source

Novel lipid mixtures based on synthetic ceramides reproduce the unique stratum corneum lipid organization

Journal of Lipid Research, 2004
Lipid lamellae present in the outermost layer of the skin protect the body from uncontrolled water loss. In human stratum corneum (SC), two crystalline lamellar phases are present, which contain mostly cholesterol, free fatty acids, and nine types of ...
Miranda W. de Jager, Gert S. Gooris, Igor P. Dolbnya, Wim Bras, Maria Ponec, Joke A. Bouwstra   +5 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Biological activity of synthetic phosphonooxyethyl analogs of lipid A and lipid A partial structures [PDF]

Infection and Immunity, 1992
We investigated the biological activity of four new synthetic analogs of lipid A, termed PE-1, PE-2, PE-3, and PE-4. All compounds contain an alpha-oxyethyl-linked (-O-CH2-CH2-) phosphoryl group in position 1 of the reducing glucosaminyl residue (GlcN I) of lipid A. PE-1 is a hexaacylated analog of Escherichia coli lipid A (compound 506).
A J, Ulmer, H, Heine, W, Feist, S, Kusumoto, T, Kusama, H, Brade, U, Schade, E T, Rietschel, H D, Flad   +8 more
openaire   +2 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Synthetic lipids employed to mimic archaeal and bacterial lipid membranes.

, 2023
List of lipids employed in this work, their chemical structure, their names according to the supplier (Avanti Polar Lipids within Merck), and their molecular weight.
Sonja-Verena Albers (201885), Stefano Pagliara (131640), David S. Milner (7313669), Alyson E. Santoro (2486341), Nicholas A. T. Irwin (3339843), Georgina Glover (4709206), Maxime Tourte (8641227), Zehra Kahveci (1418815), Urszula Łapińska (11552799), Thomas A. Richards (7313678)   +9 more
core   +1 more source

The secret life of RNA and lipids

RNA Biology
There is no life without RNA or lipids. But could there be life with only RNA and lipids? The discovery that RNA can catalyse reactions in addition to encoding information opened new directions for engineering life and the possibility of life emerging ...
Tomasz Czerniak, James P Saenz
doaj   +1 more source

Cell-Free Phospholipid Biosynthesis by Gene-Encoded Enzymes Reconstituted in Liposomes. [PDF]

PLoS ONE, 2016
The goal of bottom-up synthetic biology culminates in the assembly of an entire cell from separate biological building blocks. One major challenge resides in the in vitro production and implementation of complex genetic and metabolic pathways that can ...
Andrew Scott, Marek J Noga, Paul de Graaf, Ilja Westerlaken, Esengul Yildirim, Christophe Danelon   +5 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source