Results 81 to 90 of about 136,463 (299)
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
The effect of membrane active agents on human leukaemia cells [PDF]
, 1998 This Thesis investigates the effect of membrane-active agents, such as synthetic ether lipids (SEL), local anaesthetics and polyunsaturated fatty acids (PUFAs) on human leukaemia cells.
Jones, Eirian Wynne
core
Communications Biology, 2021 By studying the properties of a synthetic membrane mimicking an archaeal membrane and containing the apolar polyisoprenoid squalane, Salvador-Castell et al. show that lipid bilayer stability and functionality are shifted to higher temperatures under high
Marta Salvador-Castell +7 more
doaj +1 more source
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Roles of polyunsaturated fatty acids, from mediators to membranes
Journal of Lipid Research, 2020 PUFAs, such as AA and DHA, are recognized as important biomolecules, but understanding their precise roles and modes of action remains challenging. PUFAs are precursors for a plethora of signaling lipids, for which knowledge about synthetic pathways and ...
Takeshi Harayama, Takao Shimizu
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The Interaction between a Synthetic Amphiphilic Polypeptide and Lipids
Biophysical Journal, 1982 Most spectroscopic studies designed to examine the interactions between phospholipid and protein molecules in biological membranes have involved measurements of the perturbation of the orientational order of lipids due to the presence of proteins (1).
Davis, James H. +2 more
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Interaction of Synthetic Polypeptides with Lipids in Monolayers [PDF]
Bulletin of the Chemical Society of Japan, 1978 Abstract The interaction of polypeptide (benzyloxycarbonyl derivatives of basic poly(γ-amino acid), benzyl esters of acidic poly(α-amino acid), and poly(l-leucine)) and lipid (fatty acids, fatty alcohols and cholesterol) at the air–water interface was investigated. From the additivity rule of mean molecular areas and the work of collapse
Takuya Yamashita +2 more
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Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila
FEBS Letters, EarlyView.Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia +6 more
wiley +1 more source
Synthetic Approaches for Nucleic Acid Delivery: Choosing the Right Carriers
, 2019 The discovery of the genetic roots of various human diseases has motivated the exploration of different exogenous nucleic acids as therapeutic agents to treat these genetic disorders (inherited or acquired).
Rong Ni, Ying Chau, Ruilu Feng
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