Results 141 to 150 of about 1,066,470 (312)
Metal-Organic Frameworks: Synthetic Methods and Potential Applications. [PDF]
Materials (Basel), 2021 Raptopoulou CP.
europepmc +1 more source
Prescriptions and Ingredients for Controlled CC Bond Formation
Merits and drawbacks of known C-C linking procedures, such as condensation, addn., and isomerization reactions, are outlined. Two novel methods are discussed in more detail: the Cu-catalyzed alkylation of Grignard reagents, and reactions with ...
Schlosser, Manfred
core
Does Differentially Private Synthetic Data Lead to Synthetic Discoveries? [PDF]
Background Synthetic data have been proposed as a solution for sharing anonymized versions of sensitive biomedical datasets. Ideally, synthetic data should preserve the structure and statistical properties of the original data, while protecting the ...
Pahikkala, Tapio +5 more
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Modern Synthetic Methods for the Stereoselective Construction of 1,3-Dienes. [PDF]
Molecules, 2021 Soengas RG, Rodríguez-Solla H.
europepmc +1 more source
Merits and drawbacks of known C-C linking procedures, such as condensation, addn., and isomerization reactions, are outlined. Two novel methods are discussed in more detail: the Cu-catalyzed alkylation of Grignard reagents, and reactions with ...
Schlosser, Manfred
core
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Greener organic synthetic methods: Sonochemistry and heterogeneous catalysis promoted multicomponent reactions. [PDF]
Ultrason Sonochem, 2021 Machado IV +3 more
europepmc +1 more source
The synthetic control method compared to difference in differences: discussion [PDF]
, 2014 This presentation was a discussion in response to “The synthetic control method compared to difference-in-differences for evaluating pay-for-performance schemes in health care” presented by Noemi Kreif (LSHTM).
Costa Dias, Monica
core
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source