Results 121 to 130 of about 1,066,470 (312)

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Enantioconvergent catalysis

Beilstein Journal of Organic Chemistry, 2016
An enantioconvergent catalytic process has the potential to convert a racemic starting material to a single highly enantioenriched product with a maximum yield of 100%.
Justin T. Mohr, Jared T. Moore, Brian M. Stoltz   +2 more
doaj   +1 more source

A TELESCOPIC METHOD FOR THE SYNTHESIS OF 3-INDOLYL AZO DERIVATIVE [PDF]

Química Nova
In this study, a mild and facile method for the synthesis of 3-indolyl azo derivatives using indole derivatives, aniline and tert-butyl nitro compounds at room temperature was developed.
Rongfei Liu, Yiwen Huo, Qinjiang Zhou, Yue Liu, Jinxing Hu   +4 more
doaj   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

A Convenient Laboratory‐Scale Synthesis Route Toward the PPARα Agonist Pemafibrate

ChemistryOpen
Pemafibrate is a potent and selective agonist of peroxisome proliferator‐activated receptor alpha (PPARα). It was designed to improve lipid metabolism with enhanced safety and efficacy compared to traditional fibrates and is clinically approved in Japan ...
Felien Morlion, Dorien Clarisse, Karolien De Bosscher, Matthias D’hooghe   +3 more
doaj   +1 more source

A general and atom-efficient continuous-flow approach to prepare amines, amides and imines via reactive N-chloramines

Beilstein Journal of Organic Chemistry, 2018
Chloramines are an important class of reagents, providing a convenient source of chlorine or electrophilic nitrogen. However, the instability of these compounds is a problem which makes their isolation and handling difficult. To overcome these hazards, a
Katherine E. Jolley, Michael R. Chapman, A. John Blacker   +2 more
doaj   +1 more source

Hydroxy- and Amino-Phosphonates and -Bisphosphonates: Synthetic Methods and Their Biological Applications. [PDF]

Front Chem, 2022
Kaboudin B, Daliri P, Faghih S, Esfandiari H.   +3 more
europepmc   +1 more source

synthetic method

Citation: 'synthetic method' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.15364 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +1 more source

Synth: An R Package for Synthetic Control Methods in Comparative Case Studies

The R package Synth implements synthetic control methods for comparative case studies designed to estimate the causal effects of policy interventions and other events of interest (Abadie and Gardeazabal 2003; Abadie, Diamond, and Hainmueller 2010). These
Alberto Abadie, Jens Hainmueller, Alexis Diamond   +2 more
core  

Releasing multiply-imputed synthetic data generated in two stages to protect confidentiality [PDF]

"To protect the cofidentiality of survey respondents' identities and sensitive attributes, statistical agencies can release data in which cofidential values are replaced with multiple imputations. These are called synthetic data.
Reiter, Jerome P., Drechsler, Jörg
core