Results 121 to 130 of about 14,410,077 (307)

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

open access: yesMolecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic   +10 more
wiley   +1 more source

Prescriptions and Ingredients for Controlled CC Bond Formation

open access: yes
Merits and drawbacks of known C-C linking procedures, such as condensation, addn., and isomerization reactions, are outlined. Two novel methods are discussed in more detail: the Cu-catalyzed alkylation of Grignard reagents, and reactions with ...
Schlosser, Manfred
core  

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

open access: yesMolecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad   +2 more
wiley   +1 more source

A Method for Fast, High-Precision Characterization of Synthetic Biology Devices [PDF]

open access: yes, 2012
Engineering biological systems with predictable behavior is a foundational goal of synthetic biology. To accomplish this, it is important to accurately characterize the behavior of biological devices.
Weiss, Ron   +4 more
core  

Alternative Synthetic Methods through New Developments in Catalysis by Gold

open access: yes, 2008
Alternative synthetic methods through new developments in catalysis by gold are ...
ARCADI, Antonio
core   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

open access: yesMolecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both   +7 more
wiley   +1 more source

Recent Advances in BODIPY Compounds: Synthetic Methods, Optical and Nonlinear Optical Properties, and Their Medical Applications. [PDF]

open access: yesMolecules, 2022
Gurubasavaraj PM   +4 more
europepmc   +1 more source

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