Results 101 to 110 of about 14,410,077 (307)
A Convenient Laboratory‐Scale Synthesis Route Toward the PPARα Agonist Pemafibrate
ChemistryOpenPemafibrate is a potent and selective agonist of peroxisome proliferator‐activated receptor alpha (PPARα). It was designed to improve lipid metabolism with enhanced safety and efficacy compared to traditional fibrates and is clinically approved in Japan ...
Felien Morlion +3 more
doaj +1 more source
Microwave Multicomponent Synthesis
Molecules, 2009 In the manner that very important research is often performed by multidisciplinary research teams, the applications of multicomponent reactions involving the combination of multiple starting materials with different functional groups leading to the ...
Helmut M. Hügel
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Comparison of Synthetic Methods and Identification of Several Artificial Antigens of Deoxynivalenol. [PDF]
Molecules, 2023 Han L +6 more
europepmc +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
, 2002 Synthesis is one of the major endeavours of the organic chemist, and the design of a successful synthesis requires a sound knowledge of functional group chemistry, stereochemistry and organic reaction mechanisms.
Martyn Berry +2 more
core +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
A Paternò–Büchi Reaction of Aromatics with Quinones under Visible Light Irradiation
MoleculesReported herein is a Paternò–Büchi reaction of aromatic double bonds with quinones under visible light irradiation. The reactions of aromatics with quinones exposed to blue LED irradiation yielded oxetanes at −78 °C, which was attributed to both the ...
Wen-Wen Li +6 more
doaj +1 more source
Beilstein Journal of Organic Chemistry, 2016 An enantioconvergent catalytic process has the potential to convert a racemic starting material to a single highly enantioenriched product with a maximum yield of 100%.
Justin T. Mohr +2 more
doaj +1 more source
Hydroxy- and Amino-Phosphonates and -Bisphosphonates: Synthetic Methods and Their Biological Applications. [PDF]
Front Chem, 2022 Kaboudin B +3 more
europepmc +1 more source