Results 91 to 100 of about 1,066,470 (312)

The pyruvate generator is a common phenomenon in mitochondria from different rat and mouse brain regions

FEBS Letters, EarlyView.
The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber, Niki Karavasili, Matthias Kunz, Zemfira Gizatullina, Timur Gainutdinov, Stefan Vielhaber, Wolfram S. Kunz, Frank N. Gellerich   +7 more
wiley   +1 more source

Genomics and synthetic biology as a viable option to intensify sustainable use of biodiversity

, 2011
The Amazon basin is an area of mega-biodiversity. Different models have been proposed^1-8^ for the establishment of an effective conservation policy, increasing sustainability and adding value for biodiversity. Currently, a broad spectrum of technologies
Elibio Rech, Elibio L. Rech, RECH FILHO, E. L.   +2 more
core   +1 more source

Cell-free protein synthesis as a prototyping platform for mammalian synthetic biology

, 2020
The field of mammalian synthetic biology is expanding quickly, and technologies for engineering large synthetic gene circuits are increasingly accessible. However, for mammalian cell engineering, traditional tissue culture methods are slow and cumbersome,
McClymont, David W, MacDonald, James T, Canavan, Caoimhe, Jensen, Kirsten, Suckling, Lorna, Freemont, Paul S, Crone, Michael A, Siciliano, Velia, Kopniczky, Margarita B, Goetzmann, Bruno   +9 more
core   +1 more source

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

FEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia, Anna Dósa, Asha Kiran Maddali, András Jipa, Hajnalka Laczkó‐Dobos, Péter Lőw, Gábor Juhász   +6 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Comprehensive and practical guidelines for reduction synthesis of atomically precise coinage–metal nanoclusters

Polyoxometalates
As a model system for studying the structure–property relationship and surface coordination chemistry of metal nanomaterials, ligand-stabilized, atomically precise coinage–metal (Au, Ag, and Cu) nanoclusters (NCs) have attracted considerable attention ...
Qinghua Xu, Xuekun Gong, Zixiao Zhao, Lin Wang, Jing Sun, Jinlu He, Simin Li, Hui Shen   +7 more
doaj   +1 more source

Synthetic cannabinoids: Analytical methods

, 2015
Considering the growing interest in synthetic cannabinoids, we propose to review the main analytical methods allowing their detection and/or quantification in biological samples (blood, urine, oral fluid and hair) and products (powders, herbal mixtures).
Mazoyer C., Carlier J., Di Fazio V., Sastre C.   +3 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A Review of the Synthesis, Structural, and Optical Properties of TiO₂ Nanoparticles: Current State of the Art and Potential Applications

Crystals
The manufacturing techniques, structural features, and optical attributes of titanium dioxide (TiO2) nanoparticles are highlighted in this study. These nanoparticles are notable for their remarkable photocatalytic activity, cheap cost, chemical stability,
Mohd Al Saleh Alothoum
doaj   +1 more source

A simple copper-catalyzed two-step one-pot synthesis of indolo[1,2-a]quinazoline

Beilstein Journal of Organic Chemistry, 2014
A convenient CuI/L-proline-catalyzed, two-step one-pot method has been developed for the preparation of indolo[1,2-a]quinazoline derivatives using a sequential Ullmann-type C–C and C–N coupling.
Chunpu Li, Lei Zhang, Shuangjie Shu, Hong Liu   +3 more
doaj   +1 more source