Results 71 to 80 of about 14,410,077 (307)
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
A Synthetic Method to Hydrogen Radicals
Journal of the American Chemical SocietyAbstract Atomic hydrogen (H•), the union of an electron and a proton, is the smallest radical of the universe. Over the past century, advanced techniques such as electric discharge and mercury UV sensitization enabled a fundamental understanding of the reactivity of H• but fell short of providing synthetic methods to exploit its ...
Nils J. Flodén +3 more
openaire +2 more sources
Synthetic microbleeds generation for classifier training without ground truth
, 2021 BACKGROUND AND OBJECTIVE: Cerebral microbleeds (CMB) are important biomarkers of cerebrovascular diseases and cognitive dysfunctions. Susceptibility weighted imaging (SWI) is a common MRI sequence where CMB appear as small hypointense blobs.
Fazlollahi, Amir +15 more
core +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Synthetic methods to glycerol teichoic acids [PDF]
, 2012 Synthetic methods to glycerol teichoic acidsUBL - phd migration ...
Hogendorf, W.F.J.
core
Subar1/synthetic: Synthetic Data Generation
, 2021 Code to generate synthetic ...
Subar1
core +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers
FEBS Letters, EarlyView.Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui +4 more
wiley +1 more source
A TELESCOPIC METHOD FOR THE SYNTHESIS OF 3-INDOLYL AZO DERIVATIVE [PDF]
Química NovaIn this study, a mild and facile method for the synthesis of 3-indolyl azo derivatives using indole derivatives, aniline and tert-butyl nitro compounds at room temperature was developed.
Rongfei Liu +4 more
doaj +2 more sources