Results 71 to 80 of about 980,418 (266)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Procyanidins: Structural Properties, Production Methods, and Modern Applications

Molecules
Procyanidins, a class of substances widely distributed in nature, have attracted the attention of the scientific community due to their bioactive properties, especially with regard to human health. This review is based on an extensive examination of peer-
Aleksandr Yu. Zakharov, Dmitriy Berillo, Annie Ng, Damir S. Aidarkhanov, Anna V. Tukesheva, Kamila M. Temirkulova, Ainur Tanybayeva, Zulkhair A. Mansurov, Mannix P. Balanay, Vladimir V. Pavlenko   +9 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Microwave Multicomponent Synthesis

Molecules, 2009
In the manner that very important research is often performed by multidisciplinary research teams, the applications of multicomponent reactions involving the combination of multiple starting materials with different functional groups leading to the ...
Helmut M. Hügel
doaj   +1 more source

Targeted Synthetic Control Method

CoRR
The synthetic control method (SCM) estimates causal effects in panel data with a single-treated unit by constructing a counterfactual outcome as a weighted combination of untreated control units that matches the pre-treatment trajectory. In this paper, we introduce the targeted synthetic control (TSC) method, a new two-stage estimator that directly ...
Yuxin Wang, Dennis Frauen, Emil Javurek, Konstantin Hess, Yuchen Ma 0005, Stefan Feuerriegel   +5 more
openaire   +3 more sources

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

A Convenient Laboratory‐Scale Synthesis Route Toward the PPARα Agonist Pemafibrate

ChemistryOpen
Pemafibrate is a potent and selective agonist of peroxisome proliferator‐activated receptor alpha (PPARα). It was designed to improve lipid metabolism with enhanced safety and efficacy compared to traditional fibrates and is clinically approved in Japan ...
Felien Morlion, Dorien Clarisse, Karolien De Bosscher, Matthias D’hooghe   +3 more
doaj   +1 more source

Synthesis and Thermoelectric Properties of Copper Sulfides via Solution Phase Methods and Spark Plasma Sintering

Crystals, 2017
Large-scale Cu2S tetradecahedrons microcrystals and sheet-like Cu2S nanocrystals were synthesized by employing a hydrothermal synthesis (HS) method and wet chemistry method (WCM), respectively.
Yun-Qiao Tang, Zhen-Hua Ge, Jing Feng
doaj   +1 more source

Comparison of Synthetic Methods and Identification of Several Artificial Antigens of Deoxynivalenol. [PDF]

Molecules, 2023
Han L, Li Y, Jiang J, Liu C, Hou J, Wang B, Wang Z.   +6 more
europepmc   +1 more source