Results 61 to 70 of about 1,066,470 (312)

Modeling structure-function relationships in synthetic DNA sequences using attribute grammars

, 2009
Recognizing that certain biological functions can be associated with specific DNA sequences has led various fields of biology to adopt the notion of the genetic part.
Cai, Yizhi; id_orcid, Peccoud, Jean, Cai Yizhi, Cai, Yizhi, Lux, Matthew W, Adam Laura, Lux Matthew W., Matthew W. Lux, Matthew W Lux, Jean Peccoud, Laura Adam, Adam, Laura, Yizhi Cai, Peccoud Jean   +13 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Modular synthesis of the pyrimidine core of the manzacidins by divergent Tsuji–Trost coupling

Beilstein Journal of Organic Chemistry, 2016
The design, development and application of an efficient procedure for the concise synthesis of the 1,3-syn- and anti-tetrahydropyrimidine cores of manzacidins are reported.
Sebastian Bretzke, Stephan Scheeff, Felicitas Vollmeyer, Friederike Eberhagen, Frank Rominger, Dirk Menche   +5 more
doaj   +1 more source

Applications of new mass spectrometric technologies for the structural characterisation of synthetic polymers [PDF]

, 2013
The work detailed herein describes the developments made using new mass spectrometric techniques for the structural characterisation of synthetic polymers.
SMITH, MICHAEL,JONATHAN,PAUL
core  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Synthetic yeast chromosome XI design provides a testbed for the study of extrachromosomal circular DNA dynamics

, 2023
We describe construction of the synthetic yeast chromosome XI (synXI) and reveal the effects of redesign at non-coding DNA elements. The 660-kb synthetic yeast genome project (Sc2.0) chromosome was assembled from synthesized DNA fragments before CRISPR ...
Ciurkot, Klaudia, Sanchez, Mateo I., Zhao, Yu, Fanfani, Viola, McKiernan, Robert M, Blount, Benjamin A, Sanchez, Mateo I, Walker, Roy S K, Cai, Yizhi, Cai, Jitong, Bader, Joel S., Sweeney, Fiachra, Palacios-Flores, Kim, Driessen, Maureen R M, Gowers, Glen-Oliver F, Stracquadanio, Giovanni, Oliver, Stephen G., Stracquadanio, Giovanni; id_orcid, Boeke, Jef D., Cai, Yizhi; id_orcid, Gowers, Glen-Oliver F., Blount, Benjamin A., Mitchell, Leslie A., Lauer, Stephanie, Bader, Joel S, Jovicevic, Dejana, Lu, Xinyu, Lobzaev, Evgenii, Oliver, Stephen G, Driessen, Maureen R. M., Walker, Roy S. K., McKiernan, Robert M., Boeke, Jef D, Hesketh, Andy, Mitchell, Leslie A, Ellis, Tom   +35 more
core   +1 more source

Using deep learning to generate synthetic B-mode musculoskeletal ultrasound images [PDF]

, 2020
Background and Objective Deep learning approaches are common in image processing, but often rely on supervised learning, which requires a large volume of training images, usually accompanied by hand-crafted labels.
Seynnes, Olivier R., Cronin, Neil J., Cronin, NJ, Seynnes, O, Finni, Taija, Seynnes, Olivier, Cronin, Neil, Finni, T   +7 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Targeted Synthetic Control Method

CoRR
The synthetic control method (SCM) estimates causal effects in panel data with a single-treated unit by constructing a counterfactual outcome as a weighted combination of untreated control units that matches the pre-treatment trajectory. In this paper, we introduce the targeted synthetic control (TSC) method, a new two-stage estimator that directly ...
Yuxin Wang, Dennis Frauen, Emil Javurek, Konstantin Hess, Yuchen Ma 0005, Stefan Feuerriegel   +5 more
openaire   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source