Results 51 to 60 of about 14,410,077 (307)

Mathematical modelling and non-linear analysis of Synthetic Gene Regulatory Networks [PDF]

, 2010
The emerging discipline of Synthetic biology can be defined as the engineering of biology. The usefulness of a model in Synthetic biology lies in its ability to formalise the knowledge about the biological process at hand, to identify inconsistencies ...
Marucci, Lucia
core   +1 more source

Synthetic biology

, 2009
There is currently much excitement surrounding the rapidly growing discipline of synthetic biology, which utilizes the design and construction principles of engineering to develop, evolve and standardize biological components and systems. This systematic
Ali Tavassoli, Tavassoli, Ali
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Palladium‐Catalyzed Gem‐Diborylalkylation of Silyl Enol Ethers and N‐Vinylacetamide via Diboryl Carbon‐Centered Radicals

Advanced Science
Herein, a palladium‐catalyzed coupling of gem‐iododiborylalkanes with electron‐rich olefins to access β,β‐diboryl ketones and aldehydes under mild conditions is reported. This method exhibits broad substrate scope and excellent functional group tolerance.
Xiao‐Yu Xie, Yi Wei, Xin‐Yi Chen, Ming Li, Kai Hong   +4 more
doaj   +1 more source

Genomics and synthetic biology as a viable option to intensify sustainable use of biodiversity [PDF]

, 2011
The Amazon basin is an area of mega-biodiversity. Different models have been proposed^1-8^ for the establishment of an effective conservation policy, increasing sustainability and adding value for biodiversity. Currently, a broad spectrum of technologies
Elibio Rech, Elibio L. Rech, RECH FILHO, E. L.   +2 more
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

The Synthetic Genome Summer Course [PDF]

, 2018
The Synthetic Genome Summer Course was convened with the aim of teaching a wide range of researchers the theory and practical skills behind recent advances in synthetic biology and synthetic genome science, with a focus on Sc2.0, the synthetic yeast ...
Blount, Ben, Ellis, Thomas, Blount, Benjamin, Ellis, Tom   +3 more
core   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Advantages of Asymmetry: A Synthetic and Structural Exploration of s‐Triazine Chemistry Starting From Pyrrolated Ammeline and Melam

ChemistryOpen
Melam and ammeline are simple, s‐triazine‐based compounds first described by Liebig nearly 200 years ago. Outgoing from these two compounds, synthetic strategies for asymmetrically substituted s‐triazines were developed.
Thaddäus J. Koller, Alexander Pichler, Johannes N. Singer, Zehua Xu, Vasiliki Valsamidou, Reinhard M. Pritzl, Wolfgang Schnick   +6 more
doaj   +1 more source

One-pot synthesis of enantiomerically pure N-protected allylic amines from N-protected α-amino esters

Beilstein Journal of Organic Chemistry, 2016
An improved protocol for the synthesis of enantiomerically pure allylic amines is reported. N-Protected α-amino esters derived from natural amino acids were submitted to a one-pot tandem reduction–olefination process.
Gastón Silveira-Dorta, Sergio J. Álvarez-Méndez, Víctor S. Martín, José M. Padrón   +3 more
doaj   +1 more source