Results 131 to 140 of about 724 (161)

Evolutionary engineering of Saccharomyces cerevisiae: Crafting a synthetic methylotroph via self-reprogramming. [PDF]

open access: yesSci Adv
Guo F   +11 more
europepmc   +1 more source

Bioconversion of Methanol by Synthetic Methylotrophy

2021
As an important building block in the chemical industry, methanol has become an attractive substrate in biorefinery owing to its abundance and low cost. With the development of synthetic biology, metabolic engineering of non-methylotrophy to construct synthetic methylotrophy has drawn increased attention.
Feng, Guo   +6 more
openaire   +2 more sources

Synthetic Methylotrophy: A Practical Solution for Methanol-Based Biomanufacturing

Trends in Biotechnology, 2020
The increasing availability and affordability of natural gas has renewed interest in using methanol for bioproduction of useful chemicals. Engineering synthetic methylotrophy based on natural or artificial methanol assimilation pathways and genetically tractable platform microorganisms for methanol-based biomanufacturing is drawing particular attention.
Yu Wang   +4 more
openaire   +2 more sources

Improving synthetic methylotrophy via dynamic formaldehyde regulation of pentose phosphate pathway genes and redox perturbation

Metabolic Engineering, 2020
Escherichia coli is an ideal choice for constructing synthetic methylotrophs capable of utilizing the non-native substrate methanol as a carbon and energy source. All current E. coli-based synthetic methylotrophs require co-substrates. They display variable levels of methanol-carbon incorporation due to a lack of native regulatory control of ...
Julia, Rohlhill   +3 more
openaire   +2 more sources

Synthetic methylotrophy in Escherichia coli and its industrial applications

2023
Anthropogenic climate change, driven by greenhouse gas emissions, is one of humanity’s major challenges in the 21st century. Fossil-powered chemical pro-duction is a major contributor to global greenhouse gas emissions and is re-sponsible for about 1 billion metric tons of carbon dioxide equivalents annually.
openaire   +1 more source

Foundational Tools for Synthetic Methylotrophy in Saccharomyces cerevisiae

2023
The global expansion of biomanufacturing is currently limited by the availability of sugar-based microbial feedstocks. One-carbon feedstocks, like methanol, present an enticing alternative to sugar because they can be produced from organic waste, atmospheric carbon dioxide and hydrocarbons.
openaire   +1 more source

A synthetic biology toolkit for interrogating plasmid-dependent methylotrophy and enhancing methanol-based biosynthesis of Bacillus methanolicus

Abstract Bacillus methanolicus represents a thermophilic methylotroph whose methanol utilization depends on plasmid-encoded genes. It serves as a unique model for deciphering plasmid-dependent methylotrophy and an ideal chassis for low-carbon biomanufacturing using CO2-derived C1 substrates. Despite its evolutionary uniqueness and industrial potential,
Pan Liu   +14 more
openaire   +1 more source

Synthetic alternatives to Matrigel

Nature Reviews Materials, 2020
Elizabeth A Aisenbrey, William L Murphy
exaly  

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