Results 151 to 160 of about 328,019 (200)
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Lovastatin is hypertriglyceridemic in Syrian Golden hamsters
Biochemical and Biophysical Research Communications, 1988The effects of a potent HMG CoA reductase inhibitor, lovastatin, was studied in male Syrian Golden hamsters. Lovastatin (0.1% in food for 6 days) increased hamster serum triglycerides by 12-fold with 2.4-fold increase in serum cholesterol. On continuous treatment serum triglyceride and cholesterol levels gradually decreased to below control values by ...
D, Amin, S, Gustafson, M H, Perrone
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Pregnancy toxemia (eclampsia) in Syrian golden hamsters
Journal of the American Veterinary Medical Association, 1984Summary Late-term pregnant Syrian golden hamsters (Mesocricetus auratus) died within 24 hours of arrival in our facility. Disseminated thrombi were found in many organs, particularly in the kidneys, liver, intestines, and placenta. Pathogenic bacteria were not identified in bacterial cultures of the liver.
A G, Richter, N C, Lausen, A L, Lage
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Gastric metabolism of ethanol in Syrian golden hamster
Digestive Diseases and Sciences, 1995First-pass metabolism (FPM) of orally ingested alcohol has been attributed to gastric alcohol dehydrogenase (ADH) activity in both humans and rats. To determine whether gastric alcohol dehydrogenase is essential for alcohol FPM, we sought a species lacking this enzyme.
S C, Batra +5 more
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The pancreas of syrian golden hamsters
International journal of pancreatology, 1989We examined the effects of aging on the uptake of tritiated thymidine (3H-TdR) by the different cell types of the pancreas of the Syrian golden hamster. Animals, 8-22-wk-old, received 3H-TdR (2 microCi/gm) intraperitoneally and were sacrificed 1 h later. Pancreatic tissue from each animal was processed for autoradiography.
L, Rosenberg, W P, Duguid, A I, Vinik
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Tumorigenicity of cyclic nitrosamines in Syrian golden hamsters
Zeitschrift f�r Krebsforschung, 1970Nitrosoazetidine and nitrosoheptamethyleneimine have been tested by feeding in drinking water to Syrian golden hamsters. Nitrosoazetidine appeared noncarcinogenic in this species. Nitrosoheptamethyleneimine was strongly carcinogenic, producing tumors in a large proportion of the animals mainly in the forestomach, esophagus, larynx, pharynx, nasal ...
W, Lijinsky +3 more
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Toxicokinetics ofN-nitrosodimethylamine in the Syrian golden hamster
Archives of Toxicology, 1990The single-dose toxicokinetics of N-nitrosodimethylamine (NDMA) has been characterized in 8-week-old male Syrian golden hamsters by analysis using high performance liquid chromatography of serial blood samples. An i.v. bolus dose of 4.2 mumols/kg [14C]NDMA revealed biphasic first-order elimination with a terminal half-life of 8.7 +/- 1.0 min (mean ...
A J, Streeter +3 more
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The effect of 1-methoxypropylpropylnitrosamine in Syrian golden hamsters
Zeitschrift f�r Krebsforschung und Klinische Onkologie, 1977The carcinogenicity of the alpha-dipropylnitrosamine (DPN) methyl-ether, 1-methoxypropylpropylnitrosamine (1-MPPN), was investigated in Syrian hamsters for comparison with the effect of the alpha-DPN acetylester, 1-acetoxypropylpropylnitrosamine (1-APPN). It seemed possible that 1-MPPN, 1-APPN and DPN could form a common intermediate. However, contrary
J, Althoff, C, Grandjean, B, Gold
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Uptake of sidestream smoke by syrian golden hamsters
Toxicology Letters, 1987An inhalation bioassay with Syrian golden hamsters is being conducted to evaluate the toxic and carcinogenic potential of cigarette sidestream smoke (SS) relative to mainstream smoke (MS). A Hamburg II smoking machine is used to deliver MS by nose-only exposure to hamsters and a modification allows for the simultaneous collection of SS for whole-body ...
N J, Haley +3 more
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The Pathology of Proliferative Ileitis of the Golden Syrian Hamster
Pathologia veterinaria, 1967Lesions of an acute and chronic ileitis of hamsters were studied. A total of 92 animals between 6 and 12 weeks old was examined. Morbidity and mortality rates were 25 to 60% and 90% respectively. The initial lesion was epithelial hyperplasia of the ileal mucosa. Severe inflammatory changes in the ileum and adjacent structures were secondary.
A D, Boothe, N F, Cheville
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Anthrax vaccine efficacy in golden Syrian hamsters
Vaccine, 2002The efficacy of a licensed human anthrax vaccine (anthrax vaccine adsorbed, AVA) was tested in golden Syrian hamsters against a virulent Bacillus anthracis spore challenge. Groups of golden Syrian hamsters were vaccinated at either 0 and 4 weeks or 0, 4 and 8 weeks, then challenged subcutaneously (s.c.) at 10 weeks with spores of various B.
P F, Fellows +4 more
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