Golden Syrian Hamster Models for Cancer Research [PDF]
Cells, 2022 The golden Syrian hamster (Mesocricetus auratus) has long been a valuable rodent model of human diseases, especially infectious and metabolic diseases. Hamsters have also been valuable models of several chemically induced cancers such as the DMBA-induced
Zhongde Wang, Wang Zhongde
exaly +8 more sources
Efficacy of Plant-Made Human Recombinant ACE2 against COVID-19 in a Golden Syrian Hamster Model [PDF]
Viruses, 2023 Coronavirus disease 2019 (COVID-19) is a novel infectious respiratory disease caused by SARS-CoV-2. We evaluated the efficacy of a plant-based human recombinant angiotensin-converting enzyme 2 (hrACE2) and hrACE2-foldon (hrACE2-Fd) protein against COVID ...
Sung-Chul Lim +2 more
exaly +6 more sources
Protection against reinfection with D614- or G614-SARS-CoV-2 isolates in golden Syrian hamster [PDF]
Emerging Microbes and Infections, 2021 Reinfections with SARS-CoV-2 have already been documented in humans, although its real incidence is currently unknown. Besides having a great impact on public health, this phenomenon raises the question of immunity generated by a single infection is ...
Albert Bensaid +2 more
exaly +7 more sources
Identification of optimal reference genes in golden Syrian hamster with ethanol‐ and palmitoleic acid‐induced acute pancreatitis using quantitative real‐time polymerase chain reaction [PDF]
Animal Models and Experimental Medicine, 2023 Background Acute pancreatitis (AP) is a severe disorder that leads to high morbidity and mortality. Appropriate reference genes are important for gene analysis in AP.
Jinxin Miao +9 more
doaj +3 more sources
The golden (Syrian) hamster as a model for the study of reproductive biology: Past, present, and future [PDF]
Reproductive Medicine and Biology, 2019 Background The golden (Syrian) hamster (Mesocricetus auratus) is a small rodent that belongs to the Cricetidae family. It has several unique features that are advantageous for the study of reproductive and developmental biology, including a consistent ...
Michiko Hirose, Atsuo Ogura
doaj +3 more sources
Pathology and host-pathogen interactions in a golden Syrian hamster model of Nipah virus infection [PDF]
Frontiers in Veterinary ScienceNipah virus (NiV) is recognized as one of the key pathogens with pandemic potential. We have recently established a NiV hamster model, which reproduces a highly similar disease to that observed in human cases, including respiratory and neurological signs
Inés Ruedas-Torres +4 more
doaj +2 more sources
Histopathological and immunohistochemical characterization of lesions in the golden Syrian hamster model of Nipah virus infection (Bangladesh strain) [PDF]
Frontiers in Veterinary ScienceNipah virus (NiV) is recognised as a priority pathogen with pandemic potential by the World Health Organisation (WHO). The NiV-Bangladesh strain (NiV-B) has been associated with recent outbreaks in different districts of Bangladesh and the state of ...
Kirsty Swan +10 more
doaj +2 more sources
Disruption of insulin receptor substrate 2 (IRS2) causes non-obese type 2 diabetes with β-cell dysfunction in the golden (Syrian) hamster [PDF]
Scientific ReportsBecause of the advent of genome-editing technology, gene knockout (KO) hamsters have become attractive research models for diverse diseases in humans. This study established a new KO model of diabetes by disrupting the insulin receptor substrate-2 (Irs2)
Michiko Hirose +16 more
doaj +2 more sources
Generating golden Syrian hamsters with conditional alleles via zygote microinjection of CRISPR/Cas9 [PDF]
Animal Models and Experimental MedicineBackground The golden Syrian hamster is a valuable animal model for studying carcinogenesis, metabolic disorders, cardiovascular diseases, and viral infections due to its biological and pathological similarities to humans.
Wei Chen +16 more
doaj +2 more sources
Efficacy of dispirotripiperazine PDSTP in a golden Syrian hamster model of SARS-CoV-2 infection [PDF]
Frontiers in MicrobiologyThe increasing incidence of viral pandemics calls for new small-molecule therapeutics beyond traditional approaches and targets. Dispirotripiperazine, composed of two positively charged nitrogen atoms, represents an unusual scaffold in drug discovery ...
Giuseppina Sanna +8 more
doaj +2 more sources