Results 71 to 80 of about 17,815 (220)

Retatrutide Shows Multiple Metabolic Benefits in Diet‐Induced Obese MASH Mouse and Hamster Models

Obesity, Volume 34, Issue S1, Page 43-53, June 2026.
ABSTRACT Objective/Methods Our aim was to evaluate the efficacy of the triple glucagon, GIP, and GLP‐1 receptor agonist retatrutide in diet‐induced obese MASH mouse and hamster models, two preclinical models that we routinely use for assessing new therapies targeting obesity.
François Briand, Camille Le Cudennec, Estelle Grasset, Natalia Breyner, Claire Bigot, Pierre Dillard, Thierry Sulpice   +6 more
wiley   +1 more source

MOESM1 of DNA double-strand break repair is impaired in presenescent Syrian hamster fibroblasts

, 2016
Additional file 1: Figure S1. Detection of β-galactosidase activity in Syrian hamster early- and late-passage cells and human fibroblasts of different age.
Andrey Kropotov (3418292), Denis Firsanov (3418289), Ljudmila Solovjeva (3418295), Maria Svetlova (3418283), Nadezhda Pleskach (3418298), Anastasia Vasilishina (3418301), Vadim Chagin (3418286)   +6 more
core   +1 more source

Image_2_Development of a Syrian hamster anti-PD-L1 monoclonal antibody enables oncolytic adenoviral immunotherapy modelling in an immunocompetent virus replication permissive setting.tif

, 2023
IntroductionImmune checkpoint inhibitors (ICIs) have revolutionized the treatment of cancer, but preclinical testing of hypotheses such as combination therapies has been complicated, in part due to species incompatibility issues.
Marjukka Anttila (39928), Camilla Heiniö (11175855), Saru Basnet (10817676), Akseli Hemminki (95128), Victor Arias (14563064), Víctor Cervera-Carrascon (14563058), Dafne C. A. Quixabeira (10817661), James H. A. Clubb (12203420), Lyna Haybout (14563055), Katri Aro (12203435), Suvi Sorsa (11175864), Tapani Viitala (450899), Mykhailo Girych (14563052), Annabrita Hemmes (14563061), Anna Kanerva (95120), Susanna Grönberg-Vähä-Koskela (759913), Abdullah Erikat (14563073), Shreyas Kaptan (14563070), Vincenzo Cerullo (48487), Firas Hamdan (11519483), Elise Jirovec (14563067), Santeri Pakola (12203423), João Manuel Santos (12203429), Joel Schwartz (18324), Tatiana V. Kudling (10817673), Riikka Havunen (10817670), Ilpo Vattulainen (188193)   +26 more
core   +1 more source

A Case Report in a Syrian Hamster with Hyperadrenocorticism Diagnosed and Treated with Therapeutic Trial

Folia Veterinaria, 2022
This case report describes a practical approach for diagnosing and treating a 17-month-old Syrian hamster with hyperadrenocorticism based on: history, systemic signs, dermatological lesions, and therapeutic trial.
Petrou P.
doaj   +1 more source

Development and Application of a Novel Dose–Response Model for the Quantification of Clostridioides difficile Infection Risks

Risk Analysis, Volume 46, Issue 6, June 2026.
ABSTRACT The lack of a dose–response model for Clostridioides difficile, attributed to insufficient human data, challenges effective C. difficile infection (CDI) risk management. This study presents a novel murine‐derived dose–response model for C.
Elizabeth N. Paddy, M. Sohail, Oluwasola O. D. Afolabi   +2 more
wiley   +1 more source

NAD+‒circadian rhythm coupling in dementia

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract The circadian rhythm system and sleep coordinate whole‐body functions across the 24‐h cycle, yet these rhythms progressively deteriorate with neurodegenerative diseases, including dementia. Growing evidence indicates that nicotinamide adenine dinucleotide (NAD+) interacts with the circadian system through multiple molecular pathways and that ...
Shi‐qi Zhang, Jiyeon Lee, Jun‐ping Pan, Rune Enger, Harald Hrubos‐Strøm, Erik S. Musiek, Evandro Fei Fang, Weidong Le   +7 more
wiley   +1 more source

Image_6_Development of a Syrian hamster anti-PD-L1 monoclonal antibody enables oncolytic adenoviral immunotherapy modelling in an immunocompetent virus replication permissive setting.tif

, 2023
IntroductionImmune checkpoint inhibitors (ICIs) have revolutionized the treatment of cancer, but preclinical testing of hypotheses such as combination therapies has been complicated, in part due to species incompatibility issues.
Marjukka Anttila (39928), Camilla Heiniö (11175855), Saru Basnet (10817676), Akseli Hemminki (95128), Victor Arias (14563064), Víctor Cervera-Carrascon (14563058), Dafne C. A. Quixabeira (10817661), James H. A. Clubb (12203420), Lyna Haybout (14563055), Katri Aro (12203435), Suvi Sorsa (11175864), Tapani Viitala (450899), Mykhailo Girych (14563052), Annabrita Hemmes (14563061), Anna Kanerva (95120), Susanna Grönberg-Vähä-Koskela (759913), Abdullah Erikat (14563073), Shreyas Kaptan (14563070), Vincenzo Cerullo (48487), Firas Hamdan (11519483), Elise Jirovec (14563067), Santeri Pakola (12203423), João Manuel Santos (12203429), Joel Schwartz (18324), Tatiana V. Kudling (10817673), Riikka Havunen (10817670), Ilpo Vattulainen (188193)   +26 more
core   +1 more source

ChAdOx1 nCoV-19 (AZD1222) or nCoV-19-Beta (AZD2816) protect Syrian hamsters against Beta Delta and Omicron variants

Nature Communications, 2022
Whilst the ChAdOx1 nCoV-19 (AZD1222) vaccine has demonstrated efficacy against symptomatic disease, variants of concern (VOCs) with spike protein substitutions have led researchers to explore updating vaccines from ancestral spike protein.
Neeltje van Doremalen, Jonathan E. Schulz, Danielle R. Adney, Taylor A. Saturday, Robert J. Fischer, Claude Kwe Yinda, Nazia Thakur, Joseph Newman, Marta Ulaszewska, Sandra Belij-Rammerstorfer, Greg Saturday, Alexandra J. Spencer, Dalan Bailey, Colin A. Russell, Sarah C. Gilbert, Teresa Lambe, Vincent J. Munster   +16 more
doaj   +1 more source

Enhanced Sensitivity of a Modified Quaking‐Induced Conversion Diagnostic Test for the Broad Detection of Sporadic and Inherited Prion Diseases: A Retrospective Study

Annals of Neurology, Volume 99, Issue 5, Page 1303-1314, May 2026.
Objective Quaking‐induced conversion (QuIC) tests, which detect prion‐seeding activity in cerebrospinal fluid (CSF), have markedly advanced the antemortem diagnosis of prion diseases such as Creutzfeldt‐Jakob disease (CJD). These tests provide high diagnostic accuracy and enable timely differentiation from other rapidly progressive neurodegenerative ...
Jennifer Myskiw, Rebecca Fox, Dominic M.S. Kielich, Lise Lamoureux, Melanie Leonhardt, Olivia Nykvist, Jessy A. Slota, Kristen Avery, Clark Phillipson, Kathy Frost, Sharon Simon, Brian S. Appleby, Ben A. Bailey‐Elkin, Stephanie A. Booth   +13 more
wiley   +1 more source

Image_1_Development of a Syrian hamster anti-PD-L1 monoclonal antibody enables oncolytic adenoviral immunotherapy modelling in an immunocompetent virus replication permissive setting.tif

, 2023
IntroductionImmune checkpoint inhibitors (ICIs) have revolutionized the treatment of cancer, but preclinical testing of hypotheses such as combination therapies has been complicated, in part due to species incompatibility issues.
Marjukka Anttila (39928), Camilla Heiniö (11175855), Saru Basnet (10817676), Akseli Hemminki (95128), Victor Arias (14563064), Víctor Cervera-Carrascon (14563058), Dafne C. A. Quixabeira (10817661), James H. A. Clubb (12203420), Lyna Haybout (14563055), Katri Aro (12203435), Suvi Sorsa (11175864), Tapani Viitala (450899), Mykhailo Girych (14563052), Annabrita Hemmes (14563061), Anna Kanerva (95120), Susanna Grönberg-Vähä-Koskela (759913), Abdullah Erikat (14563073), Shreyas Kaptan (14563070), Vincenzo Cerullo (48487), Firas Hamdan (11519483), Elise Jirovec (14563067), Santeri Pakola (12203423), João Manuel Santos (12203429), Joel Schwartz (18324), Tatiana V. Kudling (10817673), Riikka Havunen (10817670), Ilpo Vattulainen (188193)   +26 more
core   +1 more source