Results 51 to 60 of about 17,815 (220)

Conformational Stability of Syrian Hamster Prion Protein PrP(90−231)

, 2016
Conformational Stability of Syrian Hamster Prion Protein PrP(90 ...
Teresa J. T. Pinheiro (198296), Michael T. Bowers (252202), Megan Grabenauer (2068348), Narinder Sanghera (510849), James H. Scrivens (1727059), Susan E. Slade (2047675), Thomas Wyttenbach (1564150)   +6 more
core   +1 more source

Golden Syrian Hamsters as a Model for Revisiting the Role of Biological Sex Differences in SARS-CoV-2 Infection

mBio, 2021
There is growing evidence that coronavirus disease 2019 (COVID-19) affects males more severely than females, including compelling evidence indicating that biological sex is an important clinical factor influencing disease pathology and outcomes. In their
Rafael Tomoya Michita, Indira U. Mysorekar   +1 more
doaj   +1 more source

Immune Checkpoint Inhibitors Induce Intestinal Epithelial Injury and a Senescence‐Like Phenotype

iNew Medicine, EarlyView.
ICI treatment promotes the infiltration of activated immune cells into the intestinal mucosa. This inflammatory microenvironment is associated with significant epithelial injury, characterized by the disruption of the epithelial barrier, the depletion of specialized secretory cell lineages, and the induction of a premature senescence phenotype ...
Juan Wang, Shuang Wu, Shuangbiao Wei, Weizhen Xiang, Jianshang Huang, Lei Xiong, Hua Wang, Li Zuo   +7 more
wiley   +1 more source

Characterizations of Hamster Retina as a Model for Studies of Retinal Cholesterol Homeostasis

Biology, 2021
Cholesterol homeostasis in the retina, a sensory organ in the back of the eye, has been studied in mice but not hamsters, despite the latter being more similar to humans than mice with respect to their whole-body cholesterol maintenance. The goal of this
Nicole El-Darzi, Natalia Mast, Brian Dailey, John Denker, Yong Li, Joseph Vance, Irina A. Pikuleva   +6 more
doaj   +1 more source

Triple‐Mutated HSV‐1 Expressing Soluble B7‐1 Plus CTLA‐4 Blockade Suppresses Lymph Node Metastasis in Tongue Cancer

Cancer Science, EarlyView.
In murine tongue cancer models, T‐mB7‐1, a triple‐mutated oncolytic herpes simplex virus type 1 (HSV‐1) engineered to express soluble B7‐1, suppresses cervical lymph node metastasis and improves survival, addressing a major prognostic determinant in oral squamous cell carcinoma (OSCC).
Akinari Sugauchi, Toshihiro Uchihashi, Hirotaka Ito, Miwako Iwai, Yuzuri Tsurumaki Sato, Kyoko Kurioka, Sena Zeynep Usta, Minoru Tanaka, Mikihiko Kogo, Susumu Tanaka, Hiroshi Fukuhara, Tomoki Todo   +11 more
wiley   +1 more source

Hypothalamic ventricular ependymal thyroid hormone deiodinases are an important element of circannual timing in the Siberian hamster (Phodopus sungorus) [PDF]

, 2013
Peer ...
de Vries Emmely M., Bolborea Matei, Emmely M de Vries, de Vries, Emmely M, Ebling Francis J. P., Bolborea, Matei, Morgan, Peter J, Mercer, Julian G, Annika Herwig, Wilson Dana, Mercer, Julian G., Morgan, Peter J., Matei Bolborea, Francis J P Ebling, Herwig, Annika, Ebling, Francis J P, Barrett, Perry, Perry Barrett, Dana Wilson, Julian G Mercer, Mercer Julian G., Ebling, Francis J. P., Wilson, Dana, Herwig Annika, Barrett Perry, Vries, Emmely M. de, Morgan Peter J., Peter J Morgan   +27 more
core   +1 more source

Models of Oral Epithelial Dysplasia: A Systematic Review and Temporal Analysis

Journal of Oral Pathology &Medicine, EarlyView.
ABSTRACT Background Oral squamous cell carcinoma (OSCC) is the most common malignancy of the head and neck, associated with substantial morbidity and mortality worldwide. Oral epithelial dysplasia (OED) can precede OSCC, offering a critical window for preventive and therapeutic intervention.
Zilefac Brian Ngokwe, Satutya Wicaksono, Michael McCullough, Antonio Celentano, Tami Yap   +4 more
wiley   +1 more source

Naturally Occurring CodY Variants Alter Ligand Binding, DNA Target Affinity, and Virulence in Clostridioides difficile

Molecular Microbiology, EarlyView.
Single amino acid substitutions in the global regulator CodY can alter nutrient sensing and virulence regulation in Clostridioides difficile. We show that the CodY(Y146N) and CodY(V58A) variants display altered ligand binding and reduced promoter binding, leading to derepression of toxin regulatory pathways and increased virulence in vivo.
Md Kamrul Hasan, Sourav Roy, Revathi Govind   +2 more
wiley   +1 more source

Efeitos de diferentes períodos de isolamento social sobre o comportamento de hamsters dourados (Mesocricetus auratus) a curto e longo prazo [PDF]

, 2002
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em Neurociências.Determinação dos efeitos de diferentes períodos de isolamento sobre o comportamento social do indivíduo, procurando
Rau, Débora Driemeyer Wilbert
core  

The Golgi Apparatus of Neocortical Glial Cells During Hibernation in the Syrian Hamster

Frontiers in Neuroanatomy, 2019
Hibernating mammals undergo torpor periods characterized by a general decrease in body temperature, metabolic rate, and brain activity accompanied by complex adaptive brain changes that appear to protect the brain from extreme conditions of hypoxia and ...
Gonzalo León-Espinosa, Gonzalo León-Espinosa, Javier DeFelipe, Javier DeFelipe, Javier DeFelipe, Alberto Muñoz, Alberto Muñoz, Alberto Muñoz   +7 more
doaj   +1 more source